Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation [0.03%]
蛋白激酶A调节亚基Iβ变异体的功能分化：N3A基序在PKA调控中的重要性
Maximilian Wallbott,Jui-Hung Weng,Valeria Pane et al.
Maximilian Wallbott et al.
Protein kinase A (PKA) regulatory subunit Iβ (RIβ) plays a crucial role in modulating PKA activity through its interaction with the catalytic (C) subunit. Recent studies have identified two variants of RIβ that have not been distinguishe...
RNF13 is a previously undescribed interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation [0.03%]
RING指蛋白13(RNF13)通过修饰其糖基化和成熟作用于Iduraonte 2-硫酸酯酶的新相互作用蛋白质
Valérie C Cabana,Antoine Y Bouchard,Audrey M Sénécal et al.
Valérie C Cabana et al.
Mucopolysaccharidosis type II, also known as Hunter syndrome, is a rare and fatal disease caused by mutations in the iduronate 2-sulfatase (IDS) encoding gene. Enzymatically inactive IDS variants lead to pathological accumulation of glycosa...
3'UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypes [0.03%]
ALS相关RNA的3'UTR变异体可改变亚细胞和细胞表型
Melis Savasan-Sogut,Danae Campos-Melo,Michael J Strong
Melis Savasan-Sogut
While most human genes express mRNA 3'untranslated region (3'UTR) variants of different lengths, their impact on cell physiology and disease remains largely unknown. Here, we studied 3'UTR length heterogeneity in amyotrophic lateral scleros...
Comparative analysis of metabolic and functional cardiac alterations in diet- and genetically induced mouse models of cardiac dysfunction [0.03%]
饮食和遗传诱导的小鼠心功能障碍心脏代谢和功能改变的比较分析
Christiane Ott,Patricia Baumgarten,Thorsten Henning et al.
Christiane Ott et al.
Cardiac metabolism is highly adaptive, and distinct maladaptive remodeling processes may contribute to the development of cardiac dysfunction. Here, we compared the metabolic, structural, and functional adaptations of two murine models: C57...
EHD4 and ASAP2 are critical negative regulators of the claudin-5-based endothelial barrier [0.03%]
EHD4和ASAP2是基于Claudin-5的内皮屏障的关键负调节因子
Yosuke Hashimoto,Gergő Porkoláb,Natalie Hudson et al.
Yosuke Hashimoto et al.
Disruption to barriers of the central nervous system (CNS) has been shown in both prime and drive pathologies observed across numerous neurological and ophthalmological conditions. These barriers are composed of well evolved endothelial tig...
The ribosome-associated complex regulates cytosolic translation upon mitoprotein-induced stress [0.03%]
线粒体蛋白诱导压力下核糖体相关复合物对胞液翻译的调节作用
Jiaxin Qian,Annika Nutz,Katja Hansen et al.
Jiaxin Qian et al.
The biogenesis of mitochondria relies on the import of newly synthesized precursor proteins from the cytosol. Tom70 is a mitochondrial surface receptor which recognizes precursors and serves as an interface between mitochondrial protein imp...
MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria [0.03%]
线粒体抗病毒信号蛋白寡聚化介导的抗病毒信号激活速率和效率优于过氧化物酶体
Bruno Ramos,Jéssica Sarabando,Mariana Marques et al.
Bruno Ramos et al.
Peroxisomes and mitochondria are important platforms for antiviral signal transduction, as detection of cytosolic viral RNA by retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) induces the activation of the mitochondrial antivira...
HnRNPA1 and HuR, but not PTB, modulate cap-independent translation initiation from sense and antisense human T-cell lymphotropic virus type 1 mRNAs [0.03%]
多聚腺苷酸结合蛋白HnRNPA1和HuR调节人类T细胞淋巴瘤病毒Ⅰ型正链和反义mRNA的帽子独立翻译起始，而 polypyrimidine tract-binding 蛋白则没有此功能
Brenda López-Ulloa,Dafne Mendonça,Daniela Guzmán-Correa et al.
Brenda López-Ulloa et al.
The human T-cell lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis. HTLV-1 transcribes sense and two antisense messenger RNAs (mRNAs). The spliced and unspliced antis...
Histone demethylases regulate ferroptosis in metabolic dysfunction-associated steatotic liver disease via epigenetic modification [0.03%]
组蛋白去甲基化酶通过表观遗传修饰调控代谢紊乱相关性脂肪肝病中铁死亡发生的机制研究
Wentao Huang,Wanqiu Wu,Jiaqi Xiao et al.
Wentao Huang et al.
Ferroptosis, an iron-dependent, non-apoptotic form of cell death, is characterised by pathogenic lipid reactive oxygen species accumulation, dysregulated iron homeostasis, and oxidative stress-induced membrane damage. Numerous studies have ...
Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro [0.03%]
人 Pentraxin 相关蛋白 PTX3 通过促进摄噬作用消除铁死亡的肺泡上皮细胞从而减轻爆炸引起的急性肺损伤（体外模型）
Chang-Mei Weng,Jian-Yi Kang,Zhao-Xia Duan et al.
Chang-Mei Weng et al.
Blast injuries are common in both peacetime and war, and one of the main types is lung injury, characterised by internal severity, rapid changes in condition, high mortality, and complex injury patterns. The primary pathological manifestati...