Kinetic and molecular modelling analyses of butyrylcholinesterase activity toward 'inverse' substrates [0.03%]
动力学和分子建模分析乙酰胆碱酯酶对“逆”底物的作用
Anastasia R Blinova,Zukhra Shaihutdinova,Eldar Biktibaev et al.
Anastasia R Blinova et al.
The high catalytic power of cholinesterases results from an efficient interplay between optimised structure, molecular dynamics and fine adjustment of substrates in the active site. Kinetic and molecular modelling investigations of the cata...
LAT1/SLC7A5-mediated amino acid uptake is regulated by redox signals triggered by formyl-peptide receptor 2 [0.03%]
形式肽受体2触发的氧化还原信号调节LAT1/SLC7A5介导的氨基酸摄取
Myrhiam Cassese,Chiara Brignola,Stefano Marrone et al.
Myrhiam Cassese et al.
The rewiring of amino acid (AA) metabolism is a key characteristic of cancer metabolism. Cells can only synthesize nonessential AAs, but if the demands of highly proliferating cells don't meet the endogenous synthesis capacity, AAs must be ...
Mechanism for synthesis of isomaltooligosaccharides from maltooligosaccharides by GH15 α-glucan 4(6)-α-glucosyltransferase [0.03%]
GH15 α-葡萄糖苷酶4(6)-α-葡萄糖基转移酶催化麦芽低聚糖异构化合成异麦芽低聚糖的机制研究
Tianyi Qin,Wataru Saburi,Momo Sawada Otsubo et al.
Tianyi Qin et al.
Isomaltosaccharides, composed of α-(1 → 6)-d-glucosyl residues, exhibit diverse beneficial properties depending on the degree of polymerization (DP) and attract great interest across multiple industries. The anomer-retaining transglucosid...
Tomas Sinkunas,Giedre Tamulaitiene
Tomas Sinkunas
Anti-CRISPR (Acr) proteins are small protein inhibitors that block the RNA-guided nucleic acid (DNA or RNA) targeting activity of CRISPR-Cas enzymes. Despite their shared function, Acr proteins display minimal sequence or structural similar...
Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids [0.03%]
家族性突变调节α-突触核蛋白与关键神经膜脂质的相互作用
Abid Ali,Mikhail Matveyenka,Dmitry Kurouski
Abid Ali
Progressive aggregation of α-synuclein (α-Syn) in the midbrain, hypothalamus and thalamus is linked to Parkinson's disease (PD), one of the fastest growing neurodegenerative diseases in the U.S. Studies of families with PD history reveale...
Characterisation of a cold-adapted, thermostable glucokinase from psychrophilic Pseudoalteromonas sp. AS-131 reveals how the enzyme achieves high thermal stability without loss of cold adaptation [0.03%]
来自嗜冷的Pseudoalteromonas sp. AS-131嗜冷且热稳定的葡萄糖激酶的特性揭示了该酶如何在不失去嗜冷适应性的情况下实现高热稳定性
Akane Yato,Yuki Kato,Fuyuko Hayashi et al.
Akane Yato et al.
Microorganisms living in cold environments such as the Antarctic and deep sea usually possess cold-adapted enzymes, which are known to have high catalytic efficiency and low stability owing to their flexible structures. Research on cold-ada...
Current advances in recombinant porcine reproductive and respiratory syndrome virus vaccines in plants [0.03%]
植物中重组猪繁殖与呼吸综合征病毒疫苗的最新进展
Marco Costantini,Marcello Donini
Marco Costantini
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious RNA virus that severely affects swine herds, causing respiratory and reproductive disorders with major global economic impact. Current first-generation vacci...
Yahong Xu,Jingping Liu
Yahong Xu
Although macrophages (MФs) are vital regulators of acute kidney injury (AKI), their diverse roles in renal injury and repair remain elusive. Li et al. leveraged single-cell RNA sequencing to dissect MФ dynamics at different stages of cisp...
Julija Hmeljak
Julija Hmeljak
We highlight original articles published in The FEBS Journal in 2023 and 2024 that members of our Editorial Board deemed particularly notable. The papers discussed here received nominations based on their scientific excellence, timeliness a...
CcdA chaperones CcdB against irreversible misfolding and aggregation via a cotranslational folding mechanism [0.03%]
CcdA通过共翻译折叠机制对CcdB进行分子伴侣作用以防止其不可逆错误折叠和聚集
Priyanka Bajaj,Pehu Kohli,Raghavan Varadarajan
Priyanka Bajaj
Cotranslational subunit assembly is thought to be a prominent feature throughout the proteome, but, in bacteria, there are only a limited number of experimentally confirmed examples and most involve the addition of extraneous tag sequences ...