Toshiya Senda,Yoshihisa Hirota
Toshiya Senda
Rickets, a disorder of bone formation, was originally known as nutritional rickets due to vitamin D deficiency. Advances in science have since identified various genetic forms, typically involving loss-of-function mutations in vitamin D act...
A hidden property of the iron-sulfur protein in the mononuclear iron-bound state: species-dependent structural ordering induced by magnetic fields [0.03%]
单核铁结合态铁硫蛋白的隐秘性质：磁场诱导的种类依赖性结构有序化
Shigeki Arai,Shogo Soga,Mitsuhiro Hirai et al.
Shigeki Arai et al.
The iron-sulfur (Fe-S) cluster assembly homolog 1 (ISCA1) is a ubiquitous protein conserved in various organisms. Previous work has shown that a pigeon ISCA1 (clISCA1) forms columnar oligomers in the 2Fe-2S cluster-bound state, the length o...
Praja1 E3 ubiquitin ligase and the role it plays in neurodegeneration [0.03%]
Praja1 泛素连接酶在神经退行性疾病中的作用机制研究
Kazuhiko Watabe
Kazuhiko Watabe
Protein aggregation and transmission are hallmarks of neurodegenerative diseases. Praja1 E3 ubiquitin ligase has been shown to suppress the aggregation of causative proteins in amyotrophic lateral sclerosis, frontotemporal lobar degeneratio...
Detection of endogenous LINE-1 ORF2p and its potent reverse transcriptase activity in the MCF-7 breast cancer cell line [0.03%]
在MCF-7乳腺癌细胞系中检测内源性LINE-1ORF2蛋白及其强大的逆转录酶活性
Gopal Sarkar,Sujoy Kundu,Sulakshana P Mukherjee et al.
Gopal Sarkar et al.
Long interspersed element-1 (LINE-1 or L1) is actively jumping in humans, notably in germ cells, neurons, and certain types of cancer. An active L1 is ~6.0 kb in length and encodes two proteins, designated ORF1p and ORF2p. L1 RNA binds with...
Cryo-EM structure of N-glycosylated Pomacea canaliculata hemocyanin provides insights into its role in the immune response of gastropods [0.03%]
美洲大蠊血蓝蛋白的糖基化 cryo-em 结构为腹足类免疫反应中的作用提供了见解
Tabata Romina Brola,Ignacio Rafael Chiumiento,Santiago Ituarte et al.
Tabata Romina Brola et al.
Hemocyanins are multifunctional soluble proteins found in most mollusks and some arthropods that may turn into a phenoloxidase-like enzyme (PO) associated with innate immune functions. To expand the structural understanding of gastropod hem...
USP8-EIF2S1 signaling enhances CML cell survival under TKI-induced stress [0.03%]
USP8-EIF2S1信号通路可增强TKI诱导的压力下CML细胞的存活率
Chethampadi Gopi Mohan,Keechilat Pavithran
Chethampadi Gopi Mohan
CML is primarily driven by the oncogenic BCR-ABL fusion kinase; however, tyrosine kinase inhibitor (TKI) resistance remains a significant clinical challenge. A study by Zang et al. identified USP8 as a critical mediator of this resistance. ...
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans that is alleviated by sugar supplementation [0.03%]
肠道细菌的色氨酸代谢会导致秀丽隐杆线虫毒性并可通过补充糖分缓解
Shivani Gahlot,Subodh,Jogender Singh
Shivani Gahlot
Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nicotinamide. Although dietary tryptophan is...
Impaired postsynaptic function and disruption of intermediate filaments in GLAST-knockout-induced hidden hearing loss [0.03%]
GLAST敲除小鼠隐性听力损失的突触后功能障碍和中间丝紊乱
Kefeng Ma,Fenghan Wang,Xiaoqiong Song et al.
Kefeng Ma et al.
Hidden hearing loss (HHL) is an inner ear disorder that is characterized by synaptopathy despite normal hearing thresholds. In HHL mouse models, synaptopathy and decreased wave I amplitude were the key pathological and auditory features. Ho...
Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases [0.03%]
由真菌型III聚酮合酶催化生物活性喹诺酮类和（硫）香豆素类化合物的生物合成
Nika Sokolova,Angelina Osipyan,Lili Zhang et al.
Nika Sokolova et al.
Quinolones are privileged scaffolds for drug discovery that are relatively rare in nature. Here, we characterise two promiscuous fungal polyketide synthases AthePKS and FerePKS, which we had previously found to produce 2-quinolones in vitro...
Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression [0.03%]
缺氧通过改变染色质可接近性和基因表达调节Th17/Treg平衡
Mariana Cázares-Olivera,Shiyang Song,Sofia Ylinen et al.
Mariana Cázares-Olivera et al.
Hypoxia plays an important role in multiple biological processes, including inflammation, and modulates the T helper 17 (Th17) and regulatory T-cell (Treg) imbalance that often contributes to inflammatory diseases. Although the transcriptio...