Bin Bai,Tao Wang,Xiaonan Zhang et al.
Bin Bai et al.
The protein tyrosine phosphatase PTPN22 inhibits T cell activation by dephosphorylating some essential proteins in the T cell receptor-mediated signalling pathway, and its negative regulatory function protects organisms from autoimmune dise...
Efficient CRISPR/Cas9 mediated large insertions using long single-stranded oligonucleotide donors in C. elegans [0.03%]
利用长单链寡核苷酸供体在秀丽隐杆线虫中高效进行CRISPR/Cas9介导的大片段插入突变研究
Matthew Eroglu,Bin Yu,W Brent Derry
Matthew Eroglu
Highly efficient generation of deletions, substitutions, and small insertions (up to ~ 150 bp) into the Caenorhabditis elegans genome by CRISPR/Cas9 has been facilitated by the use of single-stranded oligonucleotide donors as repair templat...
Increased demand for FAD synthesis in differentiated and stem pancreatic cancer cells is accomplished by modulating FLAD1 gene expression: the inhibitory effect of Chicago Sky Blue [0.03%]
分化和干细胞胰腺癌细胞对FAD合成需求的增加通过调节FLAD1基因表达实现：芝加哥天蓝素的抑制作用
Alessia Nisco,Tiago M A Carvalho,Maria Tolomeo et al.
Alessia Nisco et al.
FLAD1, along with its FAD synthase (FADS, EC 2.7.7.2) product, is crucial for flavin homeostasis and, due to its role in the mitochondrial respiratory chain and nuclear epigenetics, is closely related to cellular metabolism. Therefore, it i...
Binding of different hyaluronan to CD44 mediates distinct cell adhesion dynamics under shear flow [0.03%]
不同的透明质酸与CD44结合介导了不同流速下的细胞粘附动力学现象
Linda Li,Qihan Ding,Yi Wu et al.
Linda Li et al.
As a known receptor-ligand pair for mediating cell-cell or cell-extracellular matrix adhesions, cluster of differentiation 44 (CD44)-hyaluronan (HA) interactions are not only determined by molecular weight (MW) diversity of HA, but also are...
CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners [0.03%]
针对睾丸、前列腺、肾脏和（腔室型）膀胱癌的NK细胞嵌合抗原受体免疫疗法靶向CD24及鉴定直接CD24相互作用蛋白
Christian Söhngen,David J Thomas,Margaretha A Skowron et al.
Christian Söhngen et al.
Alternative therapeutic options targeting urologic malignancies, such as germ cell tumours, as well as urothelial, renal and prostate carcinomas, are still urgently needed. The membrane protein CD24 represents a promising immunotherapeutica...
Identification of a diketopiperazine-based O-GlcNAc transferase inhibitor sensitizing hepatocellular carcinoma to CDK9 inhibition [0.03%]
一种基于二酮哌嗪的O-Glc-N-乙酰基转移酶抑制剂可使肝细胞癌对CDK9抑制敏感化
Xiaoqun Shan,Rong Jiang,Dongmei Gou et al.
Xiaoqun Shan et al.
O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is an important post-translational and metabolic process in cells that is implicated in a wide range of physiological processes. O-GlcNAc transferase (OGT) is ubiquitously present in c...
Regulation of PARP1 and its apoptotic variant activity by single-stranded DNA [0.03%]
单链DNA对PARP1及其凋亡型变体活性的调节作用研究
Waghela Deeksha,Suman Abhishek,Jyotsnendu Giri et al.
Waghela Deeksha et al.
PARP1 is a nuclear protein involved in the maintenance of genomic stability. It catalyses the formation of poly(ADP-ribose) (PAR) to recruit repair proteins at the site of DNA lesions, such as double-strand and single-strand breaks. In the ...
Inhibition of epithelial-to-mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma [0.03%]
上皮间质转化的抑制可增强纳米药物治疗胰腺导管腺癌的效果
Kai-Zhou Jin,Ying Wu,Xiao-Xiao Zheng et al.
Kai-Zhou Jin et al.
Intrinsic drug resistance mechanisms of tumor cells often reduce intracellular drug concentration to suboptimal levels. Epithelial-to-mesenchymal transition (EMT) is a pivotal process in tumor progression and metastasis that confers an aggr...
Crystal structure of Leptospira LSS_01692 reveals a dimeric structure and induces inflammatory responses through Toll-like receptor 2-dependent NF-κB and MAPK signal transduction pathways [0.03%]
莱姆螺旋体LSS _ 01692晶体结构通过 toll 样受体2依赖的NF _ κB 和 MAPK信号转导通路诱导炎症反应
Shen-Hsing Hsu,Che-Ting Wu,Yuh-Ju Sun et al.
Shen-Hsing Hsu et al.
Leptospirosis is a commonly overlooked zoonotic disease that occurs in tropical and subtropical regions. Recent studies have divided the Leptospira spp. into three groups based on virulence, including pathogenic, intermediate, and saprophyt...
Yu Seby Chen,Kalle Gehring
Yu Seby Chen
Magnesium (Mg2+ ) is the most abundant divalent cation in cells and plays key roles in almost all biological processes. CBS-pair domain divalent metal cation transport mediators (CNNMs) are a newly characterized class of Mg2+ transporters p...