A screen for histone mutations that affect quiescence in S. cerevisiae [0.03%]
筛选影响模式生物酵母休眠的组蛋白突变体文库
Eric M Small,Mary Ann Osley
Eric M Small
Quiescence or G0 is a reversible state in which cells cease division but retain the ability to resume proliferation. Quiescence occurs in all organisms and is essential for stem cell maintenance and tissue renewal. It is also related to chr...
MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy [0.03%]
MAEL通过分子伴侣介导的自噬促进柠檬酸合酶和苹果酸脱氢酶降解从而促进代谢重编程及乳腺癌进展
Lin Zhou,Shuobo Ou,Ting Liang et al.
Lin Zhou et al.
Metabolic reprogramming is a hallmark of cancer. Several studies have shown that inactivation of Krebs cycle enzymes, such as citrate synthase (CS) and fumarate hydratase (FH), facilitates aerobic glycolysis and cancer progression. MAEL has...
Ca2+ -Calmodulin regulates nuclear translocation of the rice seed-specific MADS-box transcription factor OsMADS29 [0.03%]
钙离子-钙调素调节水稻特异性种子MADS盒转录因子OsMADS29的核定位
Vibha Verma,Neelima Boora,Saraswati Nayar et al.
Vibha Verma et al.
OsMADS29 (M29) is a crucial regulator of seed development in rice. The expression of M29 is strictly regulated at transcriptional as well as post-transcriptional levels. The MADS-box proteins are known to bind to DNA as dimers. However, in ...
Annabelle Klein,Muriel Rhinn,William M Keyes
Annabelle Klein
Cellular senescence is a distinct state that is frequently induced in response to ageing and stress. Yet studies have also uncovered beneficial functions in development, repair and regeneration. Current opinion therefore suggests that timel...
Darren J Baker,Masashi Narita,Pura Muñoz-Cánoves
Darren J Baker
The contribution of cellular senescence to a diverse range of biological processes, including normal physiology, ageing, and pathology were long overlooked but have now taken centre stage. In this Editorial, we will briefly outline the revi...
Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ [0.03%]
一种GTP感受激酶的分子进化：PI5P4Kβ的功能性分子进化
Koh Takeuchi,Miki Senda,Yoshiki Ikeda et al.
Koh Takeuchi et al.
Over 4 billion years of evolution, multiple mutations, including nucleotide substitutions, gene and genome duplications and recombination, have established de novo genes that translate into proteins with novel properties essential for high-...
Autism-like behavior of murine offspring induced by prenatal exposure to progestin is associated with gastrointestinal dysfunction due to claudin-1 suppression [0.03%]
孕鼠暴露于孕酮致小鼠后代出现类似自闭症的行为与Claudin-1抑制导致的胃肠功能障碍相关
Li Xiao,Jianqing Feng,Wanhua Zhang et al.
Li Xiao et al.
Autism spectrum disorders (ASD) are associated with the contribution of many prenatal risk factors; in particular, the sex hormone progestin and vitamin D receptor (VDR) are associated with gastrointestinal (GI) symptoms in ASD development,...
Self-assembly of a dimeric avidin into unique higher-order oligomers [0.03%]
二聚体avidin的自组装形成独特的高阶寡聚体
Juana Bana,Jessica Warwar,Edward A Bayer et al.
Juana Bana et al.
The dimeric avidin family has been expanded in recent years to include many new members. All of them lack the intermonomeric Trp that plays a critical role in biotin-binding. Nevertheless, these new members of the avidins maintain the high ...
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination [0.03%]
CARPs通过单泛素化调节STUB1及其致病突变体的聚集动力学
Rahul Sharma,Prema Mondal,Srinivasa M Srinivasula
Rahul Sharma
The development of neurological pathologies is linked to the accumulation of protein aggregates like alpha-synuclein in Parkinson's disease and tau protein in Alzheimer's disease. Mono- or di-ubiquitination of these molecules has been repor...
FAM237A, rather than peptide PEN and proCCK56-63, binds to and activates the orphan receptor GPR83 [0.03%]
孤儿受体GPR83的配体鉴定：FAM237A而不是肽PEN和前胃泌素释放肽CCK56-63可结合并激活GPR83受体
Hao-Zheng Li,Ya-Fen Wang,Xiao-Xia Shao et al.
Hao-Zheng Li et al.
G protein-coupled receptor 83 (GPR83) is primarily expressed in the brain and is implicated in the regulation of energy metabolism and some anxiety-related behaviours. Recently, the PCSK1N/proSAAS-derived peptide PEN, the procholecystokinin...