Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases [0.03%]
酸菌硫化菊红螺素生物合成需要由bilin reductase催化生成的藻红素红螺素异构体
Federica Frascogna,Nathan C Rockwell,Jana Hartmann et al.
Federica Frascogna et al.
Phycobiliproteins are essential components of the light-harvesting antennae in cyanobacteria and red algae, requiring covalently bound open-chain tetrapyrrole chromophores (bilins) for proper function. In the red alga Galdieria sulphuraria,...
Huma Rahil,Albert Weixlbaumer
Huma Rahil
Recruitment of the small ribosomal subunit (30S) to messenger RNA (mRNA) marks a key step in bacterial translation initiation. Recruitment begins with a 30S standby site binding single-stranded mRNA regions at or near the translation initia...
Targeting the histone-fold dimerization interface of oocyst rupture proteins from Plasmodium berghei for antimalarial inhibitor discovery [0.03%]
针对伯氏疟原虫子孢子裂解蛋白组氨酸褶皱二聚化界面的抗疟新药发现研究
Federico Ballabio,Chiara Bertaso,Marta Villa et al.
Federico Ballabio et al.
Dimerization between the histone-fold domains (HFD) of two Plasmodium Oocyst Rupture Proteins (ORP1 and ORP2) is essential for oocyst rupture in the Anopheles mosquito vector host, representing a key event in parasite transmission to humans...
A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation [0.03%]
Hanks型细菌激酶PknS通过直接磷酸化替代σ因子EcfK促进对原生动物捕食的抗性
Lídia Dos Passos Lima,Dev Sriranganadane,Daiane Laise da Silva et al.
Lídia Dos Passos Lima et al.
Serine/threonine (Ser/Thr) kinases of the Hanks-type family are widespread in bacteria, playing key roles in signal transduction. The transmembrane Ser/Thr kinase PknS (XAC4127) from the phytopathogenic bacterium Xanthomonas citri is requir...
Liver-specific BAG3 knockout delays chemically induced hepatocellular carcinoma development [0.03%]
肝特异性BAG3敲除延迟化学诱导的肝细胞癌的发生发展
Verena Damiani,Erika Pizzinato,Federica Di Marco et al.
Verena Damiani et al.
Bcl-2-associated athanogene 3 (BAG3) is a multifunctional protein involved in several cellular processes, including protein folding, degradation, apoptosis regulation, and cytoskeleton dynamics. Its dysregulation has been associated with se...
Novel amino acid aminotransferases mediate the final steps in biosynthetic pathways of branched-chain and aromatic amino acids in the hyperthermophile Thermotoga maritima [0.03%]
新的氨基酸转氨酶介导超嗜热菌 Thermotoga maritima 分支链和芳香族氨基酸生物合成途径的最终步骤
Tetsuya Miyamoto,Shunya Abe,Yuki Hoshiyama et al.
Tetsuya Miyamoto et al.
The hyperthermophile Thermotoga maritima does not possess a typical branched-chain amino acid aminotransferase or aromatic amino acid aminotransferase, leaving the biosynthetic pathways of these amino acids unclear. In this study, we identi...
Targeting the microbiota-miRNA-protease axis: A new therapeutic avenue in melanoma [0.03%]
针对微生物群-miRNA-蛋白酶轴：黑色素瘤治疗的新途径
Elias N Katsoulieris,Paraskevi Ioannou,Nikolaos A Afratis
Elias N Katsoulieris
Modulation of extracellular matrix (ECM) turnover is a critical prerequisite process underlying the onset of melanoma metastasis. ECM proteases are involved in the degradation of matrix components during ECM turnover, which is associated wi...
Bünyamin Akgül,Günnur Güler,Buket Sağlam et al.
Bünyamin Akgül et al.
Recent epitranscriptomic studies show that ribonucleic acids (RNAs) are coated with an array of chemical modifications that dictate their cellular fate. Genetic, biochemical, and genomic approaches have been employed to elucidate the molecu...
Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis [0.03%]
miR-17-92簇调节T细胞凋亡的作用有限
Katharina Hoppe,Johannes Woelk,Julia Benz et al.
Katharina Hoppe et al.
The pro-apoptotic BCL-2-interacting mediator of cell death [BIM; also known as Bcl-2-like protein 11 (BCL2L11)] is a crucial regulator of programmed cell death in immune cells, with roles in T-cell development, homeostasis, and immune respo...
Ignazio Restivo,Julija Hmeljak
Ignazio Restivo
We are delighted to present a selection of original articles, curated by FEBS Junior Section member, Dr Ignazio Restivo. These articles were published in The FEBS Journal in 2024 and 2025, and cover molecular aspects of developmental biolog...