Jon O Lundberg
Jon O Lundberg
In humans, commensal gut bacteria participate in a miniature nitrogen cycle, metabolizing dietary nitrate and nitrite. While these processes can generate harmful N-nitrosamines, they may also produce beneficial nitric oxide (NO) or ammonium...
Celebrating the immune system [0.03%]
庆祝免疫系统
Hajrah Khawaja,Julija Hmeljak
Hajrah Khawaja
This Editorial introduces our latest Focus issue on Inflammation and Immunity. We were inspired by the 2025 Nobel Prize in Physiology or Medicine, awarded for discoveries in peripheral immune tolerance, but we were motivated to look further...
Editorial
The FEBS journal. 2025 Nov 13. DOI:10.1111/febs.70324 2025
The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa [0.03%]
真菌和原生动物中芽孢酶的结构、功能及潜在治疗作用
Ane C M Duarte,Mariana N R Trujilho,Karolaine S S M Valdivia et al.
Ane C M Duarte et al.
Metacaspases are cysteine proteases found in fungi, protozoa, and plants, where they regulate critical cellular processes such as programmed cell death (PCD), cell cycle progression, and protein homeostasis. Although structurally related to...
Targeting intestinal transporter GLUT5 to alleviate the high-fructose-induced steatotic liver disease [0.03%]
靶向肠道转运体GLUT5以缓解果糖致脂肪变性肝病
Huiying Wang,Weixing Zhao,Ana Liu et al.
Huiying Wang et al.
Excessive dietary fructose consumption is a significant contributor to the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the role of the intestinal fructose transporter, glucose transporter 5 (GLU...
Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell-autonomous effects in the B-cell compartment [0.03%]
条件性删除多发性硬化易感基因ATXN1鉴定B细胞区室内的细胞自主作用
Jonathan Jacob Carver,Rachael Riley Denbrock,Cindy Carolina Martines et al.
Jonathan Jacob Carver et al.
Increasing evidence supports a mechanistic role for B cells in the pathogenesis of the autoimmune disorder multiple sclerosis (MS). We previously documented that the MS risk gene ataxin-1 (ATXN1) modulates key B-cell functions and the sever...
An inducible and podocyte-specific diphtheria toxin receptor knock-in mouse model for studying glomerular injury and chronic kidney disease progression [0.03%]
一个可诱导的、系膜细胞特异性的白喉毒素受体敲入小鼠模型用于研究肾小球损伤及慢性肾脏疾病进展
Masaki Watanabe,Momoka Kakutani,Kenta Nakano et al.
Masaki Watanabe et al.
Podocyte injury and depletion play a central role in chronic kidney disease (CKD) pathogenesis and progression. However, modeling podocyte loss with temporal control and cell-type specificity remains a major challenge. To address this, we d...
M14 substitutions in exanatide modulate alpha-synuclein aggregation [0.03%]
利拉鲁肽的M14位点替代物通过调节α-突触核蛋白聚集减少多巴胺能神经元死亡
Venkataharsha Panuganti,Kanika Manchanda,Prasad V Bharatam et al.
Venkataharsha Panuganti et al.
Clinical and epidemiological studies suggest similarities in dysregulation of pathways in type 2 diabetes (T2DM) and Parkinson's disease (PD). Efficacy of several antidiabetic drugs has been tested in PD. Exenatide, a synthetic version of e...
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape [0.03%]
揭秘：EMILIN/_MULTIMERIN_家族塑造肿瘤图景的背后机制
Evelina Poletto,Naike Casagrande,Emanuele Di Siena et al.
Evelina Poletto et al.
In recent years, the tumor microenvironment has gained recognition as a key regulator of cancer progression. A central component of the tumor microenvironment, the extracellular matrix, undergoes dynamic remodeling during tumor development ...
Molecular basis of antibiotic sensing by the TetR family regulator CecR - a structural perspective [0.03%]
CecR（ TetR 家族调节因子）的抗生素感应分子机制——结构视角分析
Agnieszka J Pietrzyk-Brzezinska,Anna Koczurowska,Marta Orlikowska et al.
Agnieszka J Pietrzyk-Brzezinska et al.
Escherichia coli HTH-type transcriptional dual regulator CecR belongs to TetR family regulators (TFRs), which regulate the expression of genes enabling bacteria to survive under stress conditions. Previous studies (Yamanaka et al., Microbio...