A supramolecular assembly of cone-specific G-protein and cryptochrome 4a on lipid bilayer [0.03%]
锥体特异性G蛋白和隐花色素4a在脂质双层上的超分子组装体
Ümmügülsüm Güzelsoy-Flügge,Srđan Vujinović,Alexander Scholten et al.
Ümmügülsüm Güzelsoy-Flügge et al.
Signal transduction processes often involve membrane-associated proteins allowing facilitated diffusion of reactive partners in a phospholipid bilayer plane. A benchmark example is phototransduction, taking place at the disk membranes of ve...
Targeting the Notch receptor dimerization domain to inhibit Notch signalling-A new avenue of therapeutics [0.03%]
靶向Notch受体二聚化结构域以抑制Notch信号通路——治疗的新途径
Gerard F Hoyne
Gerard F Hoyne
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to geneti...
Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression [0.03%]
黑素瘤细胞释放的持续表达MHCII类分子的细胞外囊泡促进免疫逃逸和癌症进展
Francesca Costantini,Caterina Di Sano,Samuele Raccosta et al.
Francesca Costantini et al.
The metastatic progression of melanoma, a highly immunogenic cancer, is often associated with constitutive expression of major histocompatibility complex (MHC) class II molecules. Their engagement leads to increased expression and activatio...
Decoding ECM remodeling: proteases as gatekeepers of Lysyl oxidase family-mediated crosslinking [0.03%]
解读ECM重塑：蛋白酶通过调控赖氨酰氧化物家族介导的交联作用发挥守门人的功能
Ashutosh Joshi,Abhi Dutta,Antara Roy et al.
Ashutosh Joshi et al.
Proteases hydrolyze the amide bond of a polypeptide chain, which can influence protein synthesis and function. This activity has been predominantly observed in the post-translational processing of lysyl oxidase (LOX) and lysyl-oxidase-like ...
Identification of Wnt-regulated genes that are repressed by, or independent of, β-catenin [0.03%]
识别由Wnt调节且受β-连环蛋白抑制或不受β-连环蛋白影响的基因
Shiyang Liu,Sara Haghani,Enrico Petretto et al.
Shiyang Liu et al.
Wnt signaling regulates metazoan development and homeostasis, in part by β-catenin-dependent activation and repression of a large number of genes. However, Wnt signaling also regulates genes independent of β-catenin, genes that are less w...
Rickettsia parkeri subverts nicotinamide adenine dinucleotide (NAD+) metabolic pathway for its survival in endothelial cells [0.03%]
立克次体Rickettsia parkeri通过劫持烟酰胺腺嘌呤二核苷酸（NAD+）代谢途径在内皮细胞中存活下来
Lichao Liu,Jeremy W Turck,Shahid Karim et al.
Lichao Liu et al.
Rickettsia parkeri rickettsiosis is an emerging tick-borne disease in humans. The bacterium R. parkeri is primarily transmitted to humans by the Gulf Coast tick, Amblyomma maculatum. Upon transmission to the host, R. parkeri infects and mul...
Automodification of N-terminal serine residues facilitates PARP2 release from DNA [0.03%]
N端丝氨酸残基的自动修饰促进PARP2从DNA上释放
Saurabh Singh Dhakar,Albert Galera-Prat,Jin Cai et al.
Saurabh Singh Dhakar et al.
ADP-ribosyltransferases PARP1 and PARP2 are involved in DNA repair mechanisms and play a major role in detecting DNA damage. PARP1/2 enzymes transfer the ADP-ribosyl moiety from NAD+ to DNA damage response proteins, histones and to itself, ...
Regulation of PHOX2B gene expression by the long non-coding natural antisense RNA PHOX2B-AS1 [0.03%]
长非编码天然反义RNA PHOX2B-AS1调节PHOX2B基因表达
Simona Di Lascio,Ana Lucia Cuadros Gamboa,Martina Bertocchi et al.
Simona Di Lascio et al.
Paired mesoderm homeobox protein 2B (PHOX2B) is a transcription factor essential for autonomic nervous system development. Heterozygous mutations in the PHOX2B gene are associated with neurodevelopmental disorders, including congenital cent...
Karen H Vousden,Hajrah Khawaja
Karen H Vousden
Karen Vousden is an internationally renowned scientist who has made seminal contributions to p53 biology and cancer metabolism. She is currently a group leader at the Francis Crick Institute in London, where she heads the 'Tumour and host m...
Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome [0.03%]
从富含海藻生物质的元基因组中表征一种系统进化上独立的PL25家族硫酸化杂多糖裂解酶ulfan酶
Andrius Jasilionis,Pavithra Sivakumar,Justyna M Dobruchowska et al.
Andrius Jasilionis et al.
Ulvan is a polysaccharide most abundant in green macroalgae biomass. Investigation of ulvan confirmed the potential of the polysaccharide for food, pharmaceutical and chemistry applications, emphasising the beneficial properties of ulvan ol...