A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry [0.03%]
高效液相色谱-四极杆飞行时间质谱技术在建立和完善自身免疫性疾病大鼠模型的代谢组学研究中应用及展望
Yao Qi,Zifeng Pi,Shu Liu et al.
Yao Qi et al.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory and autoimmune disease accompanied by the destruction and deformities of joints. Adjuvant-induced arthritis (AIA) is one of the excellent animal models of RA used to understand di...
Features of S-nitrosylation based on statistical analysis and molecular dynamics simulation: cysteine acidity, surrounding basicity, steric hindrance and local flexibility [0.03%]
基于统计分析和分子动力学模拟的S-硝基化特征：半胱氨酸酸性、周围碱性、空间位阻及局部柔性的影响
Shangli Cheng,Ting Shi,Xiao-Lei Wang et al.
Shangli Cheng et al.
S-Nitrosylation is involved in protein functional regulation and cellular signal transduction. Although intensive efforts have been made, the molecular mechanisms of S-nitrosylation have not yet been fully understood. In this work, we carri...
A copper-responsive gene cluster is required for copper homeostasis and contributes to oxidative resistance in Deinococcus radiodurans R1 [0.03%]
铜绿假单胞菌色耐氧性基因簇有助于氧化胁迫抗性和细胞分化
Zhongchao Zhao,Zhengfu Zhou,Liang Li et al.
Zhongchao Zhao et al.
Excess copper is toxic to organisms, and therefore, copper homeostasis is important for the limitation of its cellular levels. However, copper homeostasis has not been studied to date in the bacteria Deinococcus radiodurans R1, which exhibi...
Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain [0.03%]
丝氨酸8磷酸化促进锌诱导的淀粉样蛋白-β金属结合域二聚化
Alexandra A Kulikova,Philipp O Tsvetkov,Maria I Indeykina et al.
Alexandra A Kulikova et al.
Zinc-induced aggregation of the amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease (AD). Recently it was shown that phosphorylation of Aβ at Ser8 promotes the formation of toxic aggregates. In this work, we hav...
Epistatic interactions among metabolic genes depend upon environmental conditions [0.03%]
代谢基因的上位效应相互作用取决于环境条件
Chintan Jagdishchandra Joshi,Ashok Prasad
Chintan Jagdishchandra Joshi
When the effect of the state of one gene is dependent on the state of another gene in more than an additive or a neutral way, the phenomenon is termed epistasis. In particular, positive epistasis signifies that the impact of the double dele...
In silico analysis of all point mutations on the 2B domain of K5/K14 causing epidermolysis bullosa simplex: a genotype-phenotype correlation [0.03%]
基于计算的K5/K14 2B结构城所有点突变导致单纯性大疱性表皮松解症的基因型与临床表型相关性分析
Santasree Banerjee,Qian Wu,Ping Yu et al.
Santasree Banerjee et al.
Epidermolysis bullosa simplex (EBS) is a genodermatosis caused by mutations in keratins 5 and 14 (K5 and K14), which leads to fragility of basal keratinocytes and eventually epidermal cytolysis and blistering. Depending upon the severity of...
Renal protein reactivity and stability of antibiotic amphenicols: structure and affinity [0.03%]
抗生素氨比隆的肾蛋白反应性和稳定性：结构和亲和力
Fei Ding,Wei Peng,Yu-Kui Peng et al.
Fei Ding et al.
In the present work, the molecular recognition of the oldest active amphenicols by the most popular renal carrier, lysozyme, was deciphered by using fluorescence, circular dichroism (CD) and molecular modeling at the molecular scale. Steady...
GPCRserver: an accurate and novel G protein-coupled receptor predictor [0.03%]
GPCRserver：一个准确的新的G蛋白偶联受体预测工具服务器
Renxiang Yan,Xiaofeng Wang,Lanqing Huang et al.
Renxiang Yan et al.
G protein coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, pass through the cellular membrane seven times and play diverse biological roles in the cells such as signaling, transporting of molecules and cell-cel...
Jing Yu,Le Feng,Yan Wu et al.
Jing Yu et al.
To understand the molecular mechanisms of idiopathic epiretinal membranes (iERMs), the vitreous proteomes of patients with iERMs were investigated. The vitreous proteome in patients with iERMs (n = 8) and donor samples (n = 8) was analysed ...
Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites [0.03%]
模式酵母与人类血液代谢组的意外相似性及新型人类代谢物
Romanas Chaleckis,Masahiro Ebe,Tomáš Pluskal et al.
Romanas Chaleckis et al.
Metabolomics, a modern branch of chemical biology, provides qualitative and quantitative information about the metabolic states of organisms or cells at the molecular level. Here we report non-targeted, metabolomic analyses of human blood, ...