Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS [0.03%]
炎症相关抑郁下伏隔核氨基酸和嘌呤代谢不平衡的GC-MS研究
Yu Wu,Yonghong Li,Yanjuan Jia et al.
Yu Wu et al.
Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression. However, littl...
Correction: Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study [0.03%]
订正：来自Bacteroides thetaiotaomicron的二肽基肽酶III的动力学性质及其底物特异性的结构基础-一项计算研究
M Tomin,S Tomić
M Tomin
Correction for 'Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study' by M. Tomin et al., Mol. BioSyst., 2017, 13, 2407-2417.
Published Erratum
Molecular bioSystems. 2017 Nov 21;13(12):2729-2730. DOI:10.1039/c7mb90042b 2017
Conformational heterogeneity in tails of DNA-binding proteins is augmented by proline containing repeats [0.03%]
含脯氨酸重复序列增加DNA结合蛋白尾部构象异质性
Harshavardhan Khare,Debayan Dey,Chilakapati Madhu et al.
Harshavardhan Khare et al.
A cationic terminal extension or tail is a common feature of many DNA-binding proteins. We show that a particular type of tail rich in proline, alanine and lysine belongs to the class of 'flexible disorder' and consists of characteristic pe...
Mechanism of the formation of the RecA-ssDNA nucleoprotein filament structure: a coarse-grained approach [0.03%]
基于粗粒化的RecA-单链DNA核蛋白丝结构形成机制的研究
Goutam Mukherjee,Arumay Pal,Yaakov Levy
Goutam Mukherjee
In prokaryotes, the RecA protein catalyzes the repair and strand exchange of double-stranded DNA. RecA binds to single-stranded DNA (ssDNA) and forms a presynaptic complex in which the protein polymerizes around the ssDNA to form a right-ha...
Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation [0.03%]
金黄色葡萄球菌胞外囊泡(EVs)：生物被膜形成表面结合拮抗剂
Hansol Im,Sujin Lee,Steven A Soper et al.
Hansol Im et al.
The prevalence of Staphylococcus aureus worldwide as a nosocomial infectious agent is recognized but the reason behind the spread of this bacterium has remained elusive. Here, we hypothesized that the communication of S. aureus might benefi...
Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases [0.03%]
开发一种AlphaLISA高通量技术以筛选靶向蛋白精氨酸甲基转移酶的小分子抑制剂
Lakshmi Prabhu,Lan Chen,Han Wei et al.
Lakshmi Prabhu et al.
The protein arginine methyltransferase (PRMT) family of enzymes comprises nine family members in mammals. They catalyze arginine methylation, either monomethylation or symmetric/asymmetric dimethylation of histone and non-histone proteins. ...
Xue Yan Yam,Peter R Preiser
Xue Yan Yam
Host immune evasion is a key strategy for the continual survival of many microbial pathogens including Apicomplexan protozoan: Plasmodium spp., the causative agent of Malaria. The malaria parasite has evolved a variety of mechanisms to evad...
Jutty Rajan Prashanth,Sebastien Dutertre,Richard James Lewis
Jutty Rajan Prashanth
Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics. Conotoxins have a wide range of structural an...
Model system based proteomics to understand the host response during bacterial infections [0.03%]
基于模型系统的蛋白质组学研究在细菌感染过程中理解宿主反应中的作用
Arumugam Kamaladevi,Shanmugam Marudhupandiyan,Krishnaswamy Balamurugan
Arumugam Kamaladevi
Infectious diseases caused by bacterial pathogens pose a major concern to public health and, thus, greater attention must be given to providing insightful knowledge on host-pathogen interactions. There are several theories addressing the dy...
An interaction network approach to study the correlation between endocrine disrupting chemicals and breast cancer [0.03%]
用于研究内分泌干扰物与乳腺癌相关性的相互作用网络方法
Andrea Polo,Chiara Nittoli,Anna Crispo et al.
Andrea Polo et al.
Endocrine disrupting chemicals (EDCs) are natural or synthetic exogenous substances affecting human health. Although present at low concentrations in the environment, they can cause a broad range of negative effects on the endocrine functio...