Metabonomic analysis of the therapeutic effect of Potentilla discolor in the treatment of type 2 diabetes mellitus [0.03%]
运用代谢组学方法探讨委陵菜治疗2型糖尿病的作用机制研究
Yi Li,Jing-jing Li,Xiao-dong Wen et al.
Yi Li et al.
Type 2 diabetes mellitus (T2DM) is increased worldwide in parallel with the obesity epidemic. Potentilla discolor is one of the most important crude materials in Traditional Chinese medicine (TCM) for therapy of hyperglycemia and hyperlipid...
One third of dynamic protein expression profiles can be predicted by a simple rate equation [0.03%]
简化的速率方程可以预测三分之一的蛋白质动态表达轮廓
Konstantine Tchourine,Christopher S Poultney,Li Wang et al.
Konstantine Tchourine et al.
Cells respond to environmental stimuli with expression changes at both the mRNA and protein level, and a plethora of known and unknown regulators affect synthesis and degradation rates of the resulting proteins. To investigate the major pri...
A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status [0.03%]
结合化学计量学和定量NMR分析的HIV/AIDS血清代谢变化与疾病状态相关联
Tracy R McKnight,Hikari A I Yoshihara,Lungile J Sitole et al.
Tracy R McKnight et al.
Individuals infected with the human immunodeficiency virus (HIV) often suffer from concomitant metabolic complications. Treatment with antiretroviral therapy has also been shown to alter the metabolism of patients. Although chemometric anal...
Molecular docking and molecular dynamics studies on the structure-activity relationship of fluoroquinolone for the HERG channel [0.03%]
氟喹诺酮类化合物的HERG通道结构活性关系的分子对接和分子动力学研究
Fang Luo,Jiangyong Gu,Lirong Chen et al.
Fang Luo et al.
Fluoroquinolones play an important role in the treatment of serious bacterial infections, but at the same time they could lead to cardiac toxicity due to the blockage of the HERG potassium channel, which even leads to the withdrawal of some...
Irina V Nesterova,Siddieg O Elsiddieg,Evgueni E Nesterov
Irina V Nesterova
We have designed and characterized a DNA-based molecular switch which processes two physiologically relevant inputs: pH (i.e. alkalinisation) and enzymatic activity, and generates a chemical output (in situ synthesized oligonucleotide). The...
Prioritizing candidate disease miRNAs by integrating phenotype associations of multiple diseases with matched miRNA and mRNA expression profiles [0.03%]
综合匹配miRNA和mRNA表达谱的多种疾病表型关联优先筛选候选疾病miRNA
Chaohan Xu,Yanyan Ping,Xiang Li et al.
Chaohan Xu et al.
MicroRNAs (miRNAs) have been validated to show widespread disruption of function in many cancers. However, despite concerted efforts to develop prioritization approaches based on a priori knowledge of disease-associated miRNAs, uncovering o...
MCentridFS: a tool for identifying module biomarkers for multi-phenotypes from high-throughput data [0.03%]
MCentridFS：一种从高通量数据中识别多表型模块生物标志物的工具
Zhenshu Wen,Wanwei Zhang,Tao Zeng et al.
Zhenshu Wen et al.
Systematically identifying biomarkers, in particular, network biomarkers, from high-throughput data is an important and challenging task, and many methods for two-class comparison have been developed to exploit information of high-throughpu...
Jaymin J Kathiriya,Ravi Ramesh Pathak,Eric Clayman et al.
Jaymin J Kathiriya et al.
Since aberrant cell signaling pathways underlie majority of pathophysiological morbidities, kinase inhibitors are routinely used for pharmacotherapy. However, most kinase inhibitors suffer from adverse off-target effects. Inhibition of one ...
'Ome' on the range: update on high-altitude acclimatization/adaptation and disease [0.03%]
“家”在高原：高海拔环境下的生理适应与疾病研究进展
Yongjun Luo,Yuxiao Wang,Hongxiang Lu et al.
Yongjun Luo et al.
The main physiological challenge in high-altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high altitudes; the acclima...
Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding [0.03%]
二甲基肼或氯苯那敏（经典duplex小沟结合剂）以低纳摩尔解离常数与G-四联体结合，酰胺基团对于G-四联体的结合也是必不可少的
Jie Zhou,Vu Le,Dimpy Kalia et al.
Jie Zhou et al.
G-quadruplexes have shown great promise as chemotherapeutic targets, probably by inhibiting telomere elongation or downregulating oncogene expression. There have been many G-quadruplex ligands developed over the years but only a few have dr...