Plasma metabonomic profiling of lumbar disc herniation and its traditional Chinese medicine subtypes in patients by using gas chromatography coupled with mass spectrometry [0.03%]
基于气质联用技术的腰椎间盘突出症及中医证型血浆代谢谱研究
Letian Shan,Fei Liao,Hongting Jin et al.
Letian Shan et al.
Lumbar disc herniation (LDH) is a commonly occurring disease, threatening human health and life quality. Lack of a gold standard of diagnosis has hindered the efficiency and efficacy of clinical therapy against LDH. Traditional Chinese medi...
A metabolic trade-off between phosphate and glucose utilization in Escherichia coli [0.03%]
大肠杆菌在磷酸盐和葡萄糖利用之间的代谢权衡关系研究
Volker Behrends,Ram P Maharjan,Ben Ryall et al.
Volker Behrends et al.
Getting the most out of available nutrients is a key challenge that all organisms face. Little is known about how they optimize and balance the simultaneous utilization of multiple elemental resources. We investigated the effects of long-te...
Interaction of the 5-fluorouracil analog 5-fluoro-2'-deoxyuridine with 'N' and 'B' isoforms of human serum albumin: a spectroscopic and calorimetric study [0.03%]
人血清白蛋白的“N”和“B”等型与5-氟尿嘧啶类似物5-氟-2'-脱氧尿苷的作用：光谱及卡路里研究
Mohd Ishtikhar,Shawez Khan,Gamal Badr et al.
Mohd Ishtikhar et al.
Drugs and metabolites are transported in the blood by plasma proteins, such as human serum albumin (HSA). The uridine analog 2'dFUrd, which is a cytotoxic prodrug metabolite of capecitabine, has remarkable activity against solid tumors when...
Structural and functional investigation of zebrafish (Danio rerio) NOD1 leucine rich repeat domain and its interaction with iE-DAP [0.03%]
斑马鱼NOD1的结构与功能研究及其与iE-DAP的相互作用分析
Jitendra Maharana,Bikash Ranjan Sahoo,Aritra Bej et al.
Jitendra Maharana et al.
Nucleotide binding and oligomerization domain 1 (NOD1), a cytoplasmic pattern recognition receptor (PRR) and is a key component for modulating innate immunity and signaling. It is highly specific to γ-D-Glu-mDAP (iE-DAP), a cell wall compo...
Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms [0.03%]
对基因组规模的血液转录因子综合文库进行协同生物信息学分析揭示了新的控制机制
Anagha Joshi,Berthold Gottgens
Anagha Joshi
Transcription factors play a key role in the development of a disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many i...
A bird's eye view of anisatin induced convulsive seizures in brain by a (1)H NMR based metabolic approach [0.03%]
基于氢核磁共振代谢组学方法探究斑胸草雀脑部Anisatin致痫作用鸟瞰图研究
Dan-Dan Wei,Ge-Dong,Ping-Ping Guo et al.
Dan-Dan Wei et al.
Anisatin is the main convulsant component in plants of the genus Illicium, many of which are important spices or folk medicines. The neurotoxicity of anisatin has been widely investigated, mainly focusing on its action on the γ-amino butyr...
A proteomics-based methodology to investigate the protein corona effect for targeted drug delivery [0.03%]
一种基于蛋白质组学的方法来研究靶向药物输送的蛋白冠效应
D Pozzi,G Caracciolo,A L Capriotti et al.
D Pozzi et al.
Here we introduce a proteomics methodology based on nanoliquid-chromatography tandem mass spectrometry (nanoLC/MS-MS) to investigate the "protein corona effect for targeted drug delivery", an innovative strategy, which exploits the "protein...
Dynamic changes in metabolic profiles of rats subchronically exposed to mequindox [0.03%]
长期黄霉素暴露下大鼠血浆及尿液代谢轮廓的动态变化
Limiao Jiang,Xiuju Zhao,Chongyang Huang et al.
Limiao Jiang et al.
Mequindox is widely used as an antibacterial veterinary drug and a feeding additive for farm animals in China. Although its toxicity has been widely studied, little is known regarding the metabolic effects of subchronic exposure to mequindo...
8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research [0.03%]
用于核酸和酶研究的嘌呤等体积荧光探针-8-氮杂嘌呤
Jacek Wierzchowski,Jan M Antosiewicz,David Shugar
Jacek Wierzchowski
The 8-azapurines, and their 7-deaza and 9-deaza congeners, represent a unique class of isosteric (isomorphic) analogues of the natural purines, frequently capable of substituting for the latter in many biochemical processes. Particularly in...
Meiyue Song,Yan Yan,Zhenran Jiang
Meiyue Song
Predicting new drug-pathway interactions from heterogeneous biological data is important not only for the understanding of various drug response and molecular interaction processes, but also for the development of novel drugs and the therap...