Systems biosynthesis of secondary metabolic pathways within the oral human microbiome member Streptococcus mutans [0.03%]
口腔人类微生物组成员变异链球菌中的次级代谢途径的系统生物合成
Rostyslav Zvanych,Nikola Lukenda,Xiang Li et al.
Rostyslav Zvanych et al.
Streptococcus mutans, a Gram-positive human commensal and pathogen, is commonly recognized as a primary causative agent in dental caries. Metabolic activity of this strain results in the creation of acids and secreted products are recognize...
(1)H NMR based metabolomic study of the antifatigue effect of Astragali Radix [0.03%]
基于高效液相色谱-四极杆飞行时间质谱的代谢组学研究黄芪抗疲劳的作用机制(1)^1H NMR代谢组学研究黄芪的抗疲劳作用(2)
Zhen-Yu Li,Pan He,Hai-Feng Sun et al.
Zhen-Yu Li et al.
Astragali Radix (Huangqi), a well-known traditional Chinese medicinal plant, has been used for centuries as a reinforcing vital energy herb in China. In this study, the antifatigue effect of Astragali Radix was investigated by an (1)H NMR b...
Mahdieh Hadi,Sayed-Amir Marashi
Mahdieh Hadi
A promising strategy for finding new cancer drugs is to use metabolic network models to investigate the essential reactions or genes in cancer cells. In this study, we present a generic constraint-based model of cancer metabolism, which is ...
Synthesis and protein kinase C (PKC)-C1 domain binding properties of diacyltetrol based anionic lipids [0.03%]
二酰基四醇类阴离子脂质的合成及其与蛋白激酶C PKC-C1域结合性质的研究
Narsimha Mamidi,Subhankar Panda,Rituparna Borah et al.
Narsimha Mamidi et al.
The protein kinase C (PKC) family of lipid-activated kinases plays a significant role in the regulation of diverse cellular functions including tumor promotion, apoptosis, differentiation, and others. The lipophilic second messenger diacylg...
Peripheral blood mononuclear cell-based metabolomic profiling of a chronic unpredictable mild stress rat model of depression [0.03%]
基于外周血单核细胞的代谢组学谱系分析慢性轻度不可预测应激抑郁模型大鼠
Juan Li,Ge Tang,Ke Cheng et al.
Juan Li et al.
Major depressive disorder (MDD) is a debilitating mood disorder with various etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear. Peripheral blood mononuclear cells (PBMCs) have been shown to be well-suited...
Integrative analysis of transcriptomic and metabolomic profiling of ascites syndrome in broiler chickens induced by low temperature [0.03%]
低温诱发肉鸡腹水综合征转录组和代谢组整合分析
Shourong Shi,Yiru Shen,Zhenhua Zhao et al.
Shourong Shi et al.
Ascites syndrome (AS) still has an unacceptably high incidence rate in both humans and animals although there have been many studies on AS. To continue our previous pathological and biochemical investigation on the underlying mechanisms of ...
Lian Duan,Xingjiang Xiong,Yongmei Liu et al.
Lian Duan et al.
microRNAs (miRNAs) are a class of small non-coding RNA molecules consisting of 19-22 nucleotides that play an important role in a variety of biological processes, including development, differentiation, apoptosis, cell proliferation and cel...
Oligomeric state affects oxygen dissociation and diguanylate cyclase activity of globin coupled sensors [0.03%]
寡聚状态影响血红蛋白偶联传感器的氧解离和二鸟苷酸环化酶活性
Justin L Burns,D Douglas Deer,Emily E Weinert
Justin L Burns
Bacterial biofilm formation is regulated by enzymes, such as diguanylate cyclases, that respond to environmental signals and alter c-di-GMP levels. Diguanylate cyclase activity of two globin coupled sensors is shown to be regulated by gaseo...
A new approach combining LC-MS and multivariate statistical analysis for revealing changes in histone modification levels [0.03%]
结合LC-MS与多元统计分析揭示组蛋白修饰水平变化的新方法
Raphaël Bilgraer,Sylvie Gillet,Sophie Gil et al.
Raphaël Bilgraer et al.
While acting upon chromatin compaction, histone post-translational modifications (PTMs) are involved in modulating gene expression through histone-DNA affinity and protein-protein interactions. These dynamic and environment-sensitive modifi...
A multi-omics strategy resolves the elusive nature of alkaloids in Podophyllum species [0.03%]
多组学策略解析Podophyllum属植物中生物碱的复杂性
Joaquim V Marques,Doralyn S Dalisay,Hong Yang et al.
Joaquim V Marques et al.
Podophyllum hexandrum and, to a much lesser extent P. peltatum, are sources of podophyllotoxin, extensively used as a chemical scaffold for various anti-cancer drugs. In this study, integrated omics technologies (including advanced mass spe...