Probing of the combined effect of bisquaternary ammonium antimicrobial agents and acetylsalicylic acid on model phospholipid membranes: differential scanning calorimetry and mass spectrometry studies [0.03%]
双季铵盐抗菌剂与乙酰水杨酸组合对模型卵磷脂膜影响的探究：差示扫描量热法和质谱研究
N A Kasian,V A Pashynska,O V Vashchenko et al.
N A Kasian et al.
A model molecular biosystem of hydrated dipalmitoylphosphatidylcholine (DPPC) bilayers that mimics cell biomembranes is used to probe combined membranotropic effects of drugs by instrumental techniques of molecular biophysics. Differential ...
Xiuqin Liu,Jun Ding,Fuzhou Gong
Xiuqin Liu
Piwi-interacting RNA (piRNA) is a class of small non-coding RNAs about 24 to 32 nucleotides long, associated with PIWI proteins, which are involved in germline development, transposon silencing, and epigenetic regulation. Identification of ...
Predicting protein-protein interactions between human and hepatitis C virus via an ensemble learning method [0.03%]
基于集成学习方法预测人与丙型肝炎病毒间的蛋白质-蛋白质相互作用
Abbasali Emamjomeh,Bahram Goliaei,Javad Zahiri et al.
Abbasali Emamjomeh et al.
An estimated 170 million people, approximately 3% of the world population, are chronically infected with the hepatitis C virus (HCV). More than 350,000 deaths are reported annually, which are caused by HCV. HCV, similar to a variety of viru...
Identifying the potential extracellular electron transfer pathways from a c-type cytochrome network [0.03%]
基于c型细胞色素网络的潜在胞外电子传递路径识别研究
De-Wu Ding,Jun Xu,Ling Li et al.
De-Wu Ding et al.
Extracellular electron transfer (EET) is the key feature of some bacteria, such as Geobacter sulfurreducens and Shewanella oneidensis. Via EET processes, these bacteria can grow on electrode surfaces and make current output of microbial fue...
Self-oxidation of cytochrome c at methionine80 with molecular oxygen induced by cleavage of the Met-heme iron bond [0.03%]
Met80介导的细胞色素c与分子氧的自发氧化反应
Zhonghua Wang,Yuki Ando,Ari Dwi Nugraheni et al.
Zhonghua Wang et al.
Met80 of cytochrome c (cyt c) has been shown to dissociate from its heme iron when cyt c interacts with cardiolipin (CL), which triggers the release of cyt c into the cytosol initiating apoptosis. We found that the mass of human cyt c incre...
Dynamics of Gal80p in the Gal80p-Gal3p complex differ significantly from the dynamics in the Gal80p-Gal1p complex: implications for the higher specificity of Gal3p [0.03%]
与Gal1p结合的Gal80p动态特性明显不同于与Gal3p复合体中的动态特性：对Gal3p更高特异性的启示
Sanjay K Upadhyay
Sanjay K Upadhyay
The expression of the GAL gene in Sacharomyces cerevisiae is regulated by three proteins; Gal3p/Gal1p, Gal80p and Gal4p. Both Gal3p and Gal1p act as transcriptional inducers, though Gal3p has a higher activity than Gal1p. The difference in ...
Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases [0.03%]
组织提取物的结构质谱区分乳腺良恶性疾病
Kelly M Hines,Billy R Ballard,Dana R Marshall et al.
Kelly M Hines et al.
Aberrant metabolism in breast cancer tumors has been widely studied by both targeted and untargeted analyses to characterize the affected metabolic pathways. In this work, we utilize ultra-performance liquid chromatography (UPLC) in tandem ...
Peng Zhan,Yu&#x;ning Song,Yukihiro Itoh et al.
Peng Zhan et al.
Human tankyrases 1 and 2 (TNKS1/2) are attractive pharmacological biotargets, especially for the treatment of specific types of cancer. This article provides a fairly comprehensive overview of the structural biology of the TNKS-inhibitor co...
A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy [0.03%]
一种预测乳腺癌对以紫杉醇为基础的化疗药物耐药性的20基因特征signature
Dong-Xu He,Yu-Dong Xia,Xiao-Ting Gu et al.
Dong-Xu He et al.
To date, there is no effective marker to predict chemoresistance in cancers. In this study, we aimed to find a signature that can detect chemoresistance to taxane-based therapies in breast cancer. By studying the gene-expression profiling i...
Binding studies of L-3,4-dihydroxyphenylalanine with human serum albumin [0.03%]
L-3,4-二羟基苯丙氨酸与人血清白蛋白的结合研究
Daniel Pushparaju Yeggoni,Rajagopal Subramanyam
Daniel Pushparaju Yeggoni
L-Dopa has been used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. The binding interaction between L-dopa (phytochemical) and human serum albumin (HSA) under simulated physiolo...