Sabine Hummert,Katrin Bohl,David Basanta et al.
Sabine Hummert et al.
In two papers we review game theory applications in biology below the level of cognitive living beings. It can be seen that evolution and natural selection replace the rationality of the actors appropriately. Even in these micro worlds, com...
Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity [0.03%]
通过在工程低毒α-溶血孔蛋白上嫁接合成跨膜单元来恢复其细胞溶解活性
Mihoko Ui,Kousuke Harima,Toshiaki Takei et al.
Mihoko Ui et al.
The chemical modification of proteins to provide desirable functions and/or structures broadens their possibilities for use in various applications. Usually, proteins can acquire new functions and characteristics, in addition to their origi...
Proteomic analysis of rhein-induced cyt: ER stress mediates cell death in breast cancer cells [0.03%]
大黄酸诱导的蛋白质组变化分析：内质网应激介导的乳腺癌细胞死亡作用机制研究
Hui-Ju Huang,Chi-Chen Lin,Hsiu-Chuan Chou et al.
Hui-Ju Huang et al.
Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties. However, the biological effects of rhein on the behavior of breast cancers a...
The nociceptin receptor (NOPR) and its interaction with clinically important agonist molecules: a membrane molecular dynamics simulation study [0.03%]
疼痛受体(NOPR)及其与临床重要激动剂分子的相互作用：膜分子动力学模拟研究
Gugan Kothandan,Changdev G Gadhe,Anand Balupuri et al.
Gugan Kothandan et al.
The nociceptin receptor (NOPR) is an orphan G protein-coupled receptor that contains seven transmembrane helices. NOPR has a distinct mechanism of activation, though it shares a significant homology with other opioid receptors. Previously t...
Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae [0.03%]
利用模式生物S.cerevisiae的耐药突变体进行下一代测序确认苯霉菌和拉帕霉素的细胞靶点
Dustin A Wride,Nader Pourmand,Walter M Bray et al.
Dustin A Wride et al.
Investigating the mechanisms of action (MOAs) of bioactive compounds and the deconvolution of their cellular targets is an important and challenging undertaking. Drug resistance in model organisms such as S. cerevisiae has long been a means...
Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis [0.03%]
利用连接图和计算机目标预测分析小分子作用机制的基因表达数据
Aakash Chavan Ravindranath,Nolen Perualila-Tan,Adetayo Kasim et al.
Aakash Chavan Ravindranath et al.
Integrating gene expression profiles with certain proteins can improve our understanding of the fundamental mechanisms in protein-ligand binding. This paper spotlights the integration of gene expression data and target prediction scores, pr...
Katrin Bohl,Sabine Hummert,Sarah Werner et al.
Katrin Bohl et al.
In this and an accompanying paper we review the use of game theoretical concepts in cell biology and molecular biology. This review focuses on the subcellular level by considering viruses, genes, and molecules as players. We discuss in whic...
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy [0.03%]
基于核磁共振光谱的apoE（-/-）小鼠血清代谢组学分析揭示了动脉粥样硬化的进展轴线
Yongxia Yang,Ying Liu,Lingyun Zheng et al.
Yongxia Yang et al.
Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet. The aim of this study was to identify potential biomarkers for the early diagnosis and monitoring of the progression of atherogenesis in a...
Evolution of the CRISPR-Cas adaptive immunity systems in prokaryotes: models and observations on virus-host coevolution [0.03%]
细菌和古菌CRISPR-Cas适应性免疫系统的进化：病毒-宿主协同进化的模型与观察
Eugene V Koonin,Yuri I Wolf
Eugene V Koonin
CRISPR-Cas is an adaptive immunity system in prokaryotes that functions via a unique mechanism which involves incorporation of foreign DNA fragments into CRISPR arrays and subsequent utilization of transcripts of these inserts (known as spa...
Alterations in rat pulmonary phosphatidylcholines after chronic exposure to ambient fine particulate matter [0.03%]
慢性暴露于环境细颗粒物后大鼠肺部卵磷脂的变化
Wen-Ling Chen,Ching-Yu Lin,Yuan-Horng Yan et al.
Wen-Ling Chen et al.
This study elucidated the underlying pathophysiological changes that occur after chronic ambient fine particulate matter (PM2.5) exposure via a lipidomic approach. Five male Sprague-Dawley rats were continually whole-body exposed to ambient...