A microscopic insight from conformational thermodynamics to functional ligand binding in proteins [0.03%]
从构象热力学到蛋白质功能配体结合的微观见解
Samapan Sikdar,J Chakrabarti,Mahua Ghosh
Samapan Sikdar
We show that the thermodynamics of metal ion-induced conformational changes aid to understand the functions of protein complexes. This is illustrated in the case of a metalloprotein, alpha-lactalbumin (aLA), a divalent metal ion binding pro...
Clearance of the intracellular high level of the tau protein directed by an artificial synthetic hydrolase [0.03%]
由人工合成酶引导的tau蛋白胞内高浓度清除研究
Ting-Ting Chu,Qian-Qian Li,Tian Qiu et al.
Ting-Ting Chu et al.
Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furt...
Computational study of the structural plasticity and the ligand binding affinity of the IRES subdomain IIa [0.03%]
IRES子域IIa的结构可塑性及配体结合亲和力的计算研究
Marina Grabar Branilović,Sanja Tomić
Marina Grabar Branilović
The internal ribosome entry site (IRES) of hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication. In order to fulfil its role in HCV translation initiation its subdomain IIa should adopt...
A computational frame and resource for understanding the lncRNA-environmental factor associations and prediction of environmental factors implicated in diseases [0.03%]
一种用于理解长链非编码rna-环境因素关联及预测与疾病相关的环境因素的计算框架和资源
Meng Zhou,Lu Han,Jiahui Zhang et al.
Meng Zhou et al.
The complex traits of an organism are associated with a complex interplay between genetic factors (GFs) and environmental factors (EFs). However, compared with protein-coding genes and microRNAs, there is a paucity of computational methods ...
Role of a remote leucine residue in the catalytic function of polyol dehydrogenase [0.03%]
远程的亮氨酸残基在多元醇脱氢酶催化功能中的作用
Manish Kumar Tiwari,Vipin C Kalia,Yun Chan Kang et al.
Manish Kumar Tiwari et al.
Studies on the protein-metal binding sites have mainly focused on the residues immediately surrounding the reacting substrate, cofactors, and metal ions. The contribution of residues in remote layers to the highly optimized microenvironment...
Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer [0.03%]
基于基因模块的调节因素推理鉴别出miR-139可抑制结直肠癌肿瘤发展
Jin Gu,Yang Chen,Huiya Huang et al.
Jin Gu et al.
Colorectal cancer is one of the most commonly diagnosed cancer types worldwide. Identification of the key regulators of the altered biological networks is crucial for understanding the complex molecular mechanisms of colorectal cancer. We p...
Investigating the functional implications of reinforcing feedback loops in transcriptional regulatory networks [0.03%]
探究转录调控网络中强化反馈回路的功能含义
Yue Li,Cheng Liang,Steve Easterbrook et al.
Yue Li et al.
Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate transcriptional networks in the form of recurrent circuits or motifs. A motif can be divided into a feedforward loop (FFL) and a feedback loop (FBL). Incoherent FFLs ha...
Quercetin 3-O-rutinoside mediated inhibition of PBP2a: computational and experimental evidence to its anti-MRSA activity [0.03%]
芦丁通过抑制PBP2a抗菌的计算和实验证据
Nidhi Rani,Saravanan Vijayakumar,Lakshmi Palanisamy Thanga Velan et al.
Nidhi Rani et al.
The PBP2a is a cell wall synthesizing protein, which causes resistivity in methicillin resistant Staphylococcus aureus (MRSA) from β-lactam antibiotics but it is susceptible to 5th generation cephalosporin, ceftobiprole. Ceftobiprole inhib...
Sampo Kukkurainen,Juha A Määttä,John Saeger et al.
Sampo Kukkurainen et al.
The major mechanical function of talin is to couple the β-integrin cytoplasmic tails to actin filaments. A variety of β-integrin tails contain conserved binding motifs for talin, and recent research shows that β-integrins differ both in ...
A single amino acid substitution affects the substrate specificity of the seryl-tRNA synthetase homologue [0.03%]
一个单一氨基酸的取代影响丝氨酸-tRNA合成酶同源物的底物特异性
Aleksandra Maršavelski,Sonja Lesjak,Marko Močibob et al.
Aleksandra Maršavelski et al.
Recently described and characterized Bradyrhizobium japonicum glycine:[carrier protein] ligase 1 (Bj Gly:CP ligase 1), a homologue of methanogenic type seryl-tRNA synthetase (SerRS) is an intriguing enzyme whose physiological role is not ye...