Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds [0.03%]
基于分子动力学的新型磷二酯酶-9A非吡唑并.pyr嘧啶酮支架抑制剂的发现
Zhe Li,Xiao Lu,Ling-Jun Feng et al.
Zhe Li et al.
Phosphodiesterase-9A (PDE9A) is a promising therapeutic target for the treatment of diabetes and Alzheimer's disease (AD). The Pfizer PDE9A inhibitor PF-04447943 has completed Phase II clinical trials in subjects with mild to moderate AD in...
Network motif frequency vectors reveal evolving metabolic network organisation [0.03%]
网络动机频率向量揭示了代谢网络的演变组织方式
Nicole Pearcy,Jonathan J Crofts,Nadia Chuzhanova
Nicole Pearcy
At the systems level many organisms of interest may be described by their patterns of interaction, and as such, are perhaps best characterised via network or graph models. Metabolic networks, in particular, are fundamental to the proper fun...
CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer [0.03%]
CIP2A在非小细胞肺癌中的癌症代谢及CREB磷酸化调控作用研究
Bo Peng,Ningjing Lei,Yurong Chai et al.
Bo Peng et al.
The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in ...
In vitro selection of DNA-based aptamers that exhibit RNA-like conformations using a chimeric oligonucleotide library that contains two different xeno-nucleic acids [0.03%]
利用含有两种不同异核酸的嵌合寡核苷酸文库选择具有RNA类似构象的DNA适配体
Kenta Hagiwara,Hiroto Fujita,Yuuya Kasahara et al.
Kenta Hagiwara et al.
We successfully generated chimeric DNA aptamers that contained six nucleoside analogs of 2'-O,4'-C-methylene bridged/locked nucleic acid (2',4'-BNA/LNA) in the primer region and multiple guanosine analogs of 2'-deoxy-2'-fluoro-ribonucleic a...
Affinity proteomics led identification of vimentin as a potential biomarker in colon cancers: insights from serological screening and computational modelling [0.03%]
亲和蛋白质组学引导的波形蛋白作为结直肠癌生物标志物的鉴定研究：基于血清学筛查及计算模型的分析结果
Shoiab Bukhari,Taseem A Mokhdomi,Naveed A Chikan et al.
Shoiab Bukhari et al.
Proteomic analysis using multiplex affinity reagents is perhaps the most reliable strategy to capture differentially expressed proteins that are slightly or immensely modified. In addition to expressional variation, it is comprehensively ev...
MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis [0.03%]
基于时间分辨代谢组数据的动态约束-based通量平衡分析模型
A Marcel Willemsen,Diana M Hendrickx,Huub C J Hoefsloot et al.
A Marcel Willemsen et al.
Understanding cellular adaptation to environmental changes is one of the major challenges in systems biology. To understand how cellular systems react towards perturbations of their steady state, the metabolic dynamics have to be described....
Identifying progression related disease risk modules based on the human subcellular signaling networks [0.03%]
基于人体细胞信号网络的与疾病进展相关的风险模块识别
Ruiqiang Xie,Hao Huang,Wan Li et al.
Ruiqiang Xie et al.
Many studies have shown that the structure and dynamics of the human signaling network are disturbed in complex diseases such as coronary artery disease, and gene expression profiles can distinguish variations in diseases since they can acc...
Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells [0.03%]
综合分析显示STAT3在人乳腺上皮细胞HER/ErbB受体信号通路交叉谈话中处于核心地位
Chunhong Gong,Yi Zhang,Harish Shankaran et al.
Chunhong Gong et al.
Human epidermal growth factor receptors (HER, also known as ErbB) drive cellular proliferation, pro-survival and stress responses by activating several downstream kinases, in particular ERK, p38 MAPK, JNK (SAPK), the PI3K/AKT, as well as va...
Investigation of the therapeutic effectiveness of active components in Sini decoction by a comprehensive GC/LC-MS based metabolomics and network pharmacology approaches [0.03%]
基于LC/GC-MS代谢组学和网络药理学的四逆汤活性成分治疗有效性的研究
Si Chen,Si Wu,Wuhong Li et al.
Si Chen et al.
As a classical formula, Sini decoction (SND) has been fully proved to be clinically effective in treating doxorubicin (DOX)-induced cardiomyopathy. Current chemomics and pharmacology proved that the total alkaloids (TA), total gingerols (TG...
Network-based sub-network signatures unveil the potential for acute myeloid leukemia therapy [0.03%]
基于网络的亚型特征揭示其潜在治疗方法以治疗急性髓系白血病
Mingguang Shi,Min Wu,Ping Pan et al.
Mingguang Shi et al.
Although gene expression profiling studies of acute myeloid leukemia (AML) patients have provided key insights into potential diagnostic and prognostic markers and therapeutic targets, it is not clear that the patterns of molecular heteroge...