A multiscale agent-based framework integrated with a constraint-based metabolic network model of cancer for simulating avascular tumor growth [0.03%]
一种多尺度的个体基于框架与约束下的代谢网络模型结合模拟癌无血管肿瘤生长模型
Mehrdad Ghadiri,Mahshid Heidari,Sayed-Amir Marashi et al.
Mehrdad Ghadiri et al.
In recent years, many efforts have been made in the field of computational modeling of cancerous tumors, in order to obtain a better understanding and predictions of their growth patterns. Furthermore, constraint-based modeling of metabolic...
DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus [0.03%]
DBA诱导的大鼠海马体caspase-3依赖性细胞凋亡与细胞色素C的线粒体易位有关
Wenbo Jiang,Yingying Chen,Bai Li et al.
Wenbo Jiang et al.
Dibromoacetic acid (DBA), a by-product of disinfection, develops in drinking water during chlorination or ozonation processes. Water intake is the main source of DBA exposure in humans, which is potentially neurotoxic. The present study inv...
Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in type 2 diabetes subjects [0.03%]
体外细胞表型和血浆代谢谱与2型糖尿病线粒体功能障碍的关系
Mohamad Hafizi Abu Bakar,Mohamad Roji Sarmidi
Mohamad Hafizi Abu Bakar
Accumulating evidence implicates mitochondrial dysfunction-induced insulin resistance in skeletal muscle as the root cause for the greatest hallmarks of type 2 diabetes (T2D). However, the identification of specific metabolite-based markers...
Peculiarities of thermal denaturation of OmpF porin from Yersinia ruckeri [0.03%]
耶尔森氏鱼肠道杆菌OmpF孔蛋白热变性特点
Olga D Novikova,Dmitry K Chistyulin,Valentina A Khomenko et al.
Olga D Novikova et al.
Irreversible denaturation of membrane proteins in detergent solutions is similar to unfolding of water-soluble multidomain proteins and represents a complex, multistage process. Pore-forming proteins of Gram-negative bacteria are heat-modif...
Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch [0.03%]
CRMP2硫醇开关的分子动力学模拟及体外分析研究
Daniel Möller,Manuela Gellert,Walter Langel et al.
Daniel Möller et al.
The collapsin response mediator protein CRMP2 (gene: DPYSL2) is crucial for neuronal development. The homotetrameric CRMP2 complex is regulated via two mechanisms: first by phosphorylation and second by the reduction and oxidation of the Cy...
An efficient method to transcription factor binding sites imputation via simultaneous completion of multiple matrices with positional consistency [0.03%]
一种通过同时完成多个具有位置一致性的矩阵来推断转录因子结合位点的有效方法
Wei-Li Guo,De-Shuang Huang
Wei-Li Guo
Transcription factors (TFs) are DNA-binding proteins that have a central role in regulating gene expression. Identification of DNA-binding sites of TFs is a key task in understanding transcriptional regulation, cellular processes and diseas...
A comparative review of computational methods for pathway perturbation analysis: dynamical and topological perspectives [0.03%]
从动力学和拓扑学角度比较通路扰动分析的计算方法
Q Vanhaelen,A M Aliper,A Zhavoronkov
Q Vanhaelen
Stem cells offer great promise within the field of regenerative medicine but despite encouraging results, the large scale use of stem cells for therapeutic applications still faces challenges when it comes to controlling signaling pathway r...
The antiproliferative activity of di-2-pyridylketone dithiocarbamate is partly attributed to catalase inhibition: detailing the interaction by spectroscopic methods [0.03%]
二吡啶甲酮二硫碳酰胺的抗增殖活性部分归因于催化酶抑制：通过光谱法详细描述相互作用
Cuiping Li,Youxun Liu,Yun Fu et al.
Cuiping Li et al.
The bioactivity of drugs is attributed to their interaction with biological molecules, embodied in either their direct or indirect influence on enzyme activity and conformation. Di-2-pyridylketone hydrazine dithiocarbamate (DpdtC) exhibits ...
Insights into the RNA binding mechanism of human L1-ORF1p: a molecular dynamics study [0.03%]
关于人类L1-ORF1p的RNA结合机制的研究：基于分子动力学模拟
Muthukumaran Rajagopalan,Sangeetha Balasubramanian,Amutha Ramaswamy
Muthukumaran Rajagopalan
The recognition and binding of nucleic acids by ORF1p, an L1 retrotransposon protein, have not yet been clearly understood due to the lack of structural knowledge. The present study attempts to identify the probable single-stranded RNA bind...
Ander Camiruaga,Imanol Usabiaga,Aran Insausti et al.
Ander Camiruaga et al.
We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the synthesis of glycogen. The IR spectra show that the aromatic ring acts as bait to keep the position where the next glucose unit ...