Insights into the Giardia intestinalis enolase and human plasminogen interaction [0.03%]
隐孢子虫烯醇酶与人纤溶酶原相互作用的见解
R Aguayo-Ortiz,P Meza-Cervantez,R Castillo et al.
R Aguayo-Ortiz et al.
Giardia intestinalis is an intestinal parasite that causes diarrhea in humans and animals worldwide. The enolase of G. intestinalis (GiENO) participates in its glycolysis pathway and is abundantly expressed in the parasite cytosol; however,...
Coarse-grained simulations of conformational changes in the multidrug efflux transporter AcrB [0.03%]
多药外排转运蛋白AcrB构象变化的粗粒度模拟研究
Yead Jewel,Jin Liu,Prashanta Dutta
Yead Jewel
The multidrug resistance (MDR) system actively pumps antibiotics out of cells causing serious health problems. During the pumping, AcrB (one of the key components of MDR) undergoes a series of large-scale and proton-motive conformational ch...
Cynthia Martins Villar Couto,César Henrique Comin,Luciano da Fontoura Costa
Cynthia Martins Villar Couto
Several developments regarding the analysis of gene co-expression profiles using complex network theory have been reported recently. Such approaches usually start with the construction of an unweighted gene co-expression network, therefore ...
Michael J Booth,Vanessa Restrepo Schild,Florence G Downs et al.
Michael J Booth et al.
Droplet interface bilayers (DIBs), comprising individual lipid bilayers between pairs of aqueous droplets in an oil, are proving to be a useful tool for studying membrane proteins. Recently, attention has turned to the elaboration of networ...
MALDI MS imaging investigation of the host response to visceral leishmaniasis [0.03%]
基质辅助激光解析电离飞行时间质谱成像技术研究内脏利什曼病的宿主响应反应
C F Jaegger,F Negrão,D M Assis et al.
C F Jaegger et al.
Mass spectrometry imaging (MSI) of animal tissues has become an important tool for in situ molecular analyses and biomarker studies in several clinical areas, but there are few applications in parasitological studies. Leishmaniasis is a neg...
2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway [0.03%]
己二酮通过PI3K/Akt/m TOR途径诱导VSC4.1细胞发生自噬死亡
Huai Guan,Hua Piao,Zhiqiang Qian et al.
Huai Guan et al.
2,5-Hexanedione (HD) is an important bioactive metabolite of n-hexane, which mediates the neurotoxicity of the parent compound. Increasing evidence suggests that over-activated autophagy can lead to autophagic neuronal death; however, wheth...
Systems-level organization of non-alcoholic fatty liver disease progression network [0.03%]
非酒精性脂肪肝病进展网络的系统级组织结构
K Shubham,L Vinay,P K Vinod
K Shubham
Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex spectrum of diseases ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH) with fibrosis, which can progress to cirrhosis and hepatocellular carcinoma. The pathogenesis ...
Expediting dynamics approach to understand the influence of 14-3-3ζ causing metastatic cancer through the interaction of YAP1 and β-TRCP [0.03%]
通过YAP1和β-TRCP相互作用加速动力学方法研究14-3-3ζ诱导转移性癌症的机制
Kamalesh D,Sriroopreddy Ramireddy,Raguraman P et al.
Kamalesh D et al.
The 14-3-3ζ protein acts as a molecular switch in regulating the TGF-β pathway, which alters from a tumor suppressor in the early stage of breast cancer to a promoter of metastasis in the late stage. This change is due to the binding of 1...
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer [0.03%]
系统分析识别出转录因子ASCL1在胶质瘤和小细胞肺癌中调控的不同功能网络及共同功能网络
Sainitin Donakonda,Swati Sinha,Shrinivas Nivrutti Dighe et al.
Sainitin Donakonda et al.
ASCL1 is a basic Helix-Loop-Helix transcription factor (TF), which is involved in various cellular processes like neuronal development and signaling pathways. Transcriptome profiling has shown that ASCL1 overexpression plays an important ro...
Protein stability and dynamics influenced by ligands in extremophilic complexes - a molecular dynamics investigation [0.03%]
极端嗜极生物复合物中配体对蛋白质稳定性和动力学影响的分子动力学研究
Sara Khan,Umar Farooq,Maria Kurnikova
Sara Khan
In this study, we explore the structural and dynamic adaptations of the Tryptophan synthase α-subunit in a ligand bound state in psychrophilic, mesophilic and hyperthermophilic organisms at different temperatures by MD simulations. We quan...