Impact of phenylalanines outside the dimer interface on phosphotriesterase stability and function [0.03%]
苯丙氨酸残基对磷三酯酶稳定性和功能的影响
Andrew J Olsen,Leif A Halvorsen,Ching-Yao Yang et al.
Andrew J Olsen et al.
We explore the significance of phenylalanine outside of the phosphotriesterase (PTE) dimer interface through mutagenesis studies and computational modeling. Previous studies have demonstrated that the residue-specific incorporation of para-...
Dissection of the module network implementation "LemonTree": enhancements towards applications in metagenomics and translation in autoimmune maladies [0.03%]
模块网络实现"LemonTree"的剖析：在元基因组学及自身免疫性疾病中的应用展望及其转化应用
Youtao Lu,Xiaoyuan Zhou,Christine Nardini
Youtao Lu
Under the current deluge of omics, module networks distinctively emerge as methods capable of not only identifying inherently coherent groups (modules), thus reducing dimensionality, but also hypothesizing cause-effect relationships between...
Quantitative investigation of MDA-MB-231 breast cancer cell motility: dependence on epidermal growth factor concentration and its gradient [0.03%]
表皮生长因子浓度及其梯度对MDA-MB-231乳腺癌细胞迁移的影响及定量研究
Tanzila Islam,Haluk Resat
Tanzila Islam
Enhanced cell motility is one of the primary features of cancer. Accumulated evidence demonstrates that Epidermal Growth Factor Receptor (EGFR) mediated pathways play an important role in breast cancer cell proliferation and migration. We h...
Proximity aptasensor for protein detection based on an enzyme-free amplification strategy [0.03%]
一种基于无酶扩增策略的用于蛋白质检测的邻近性适配子传感器
Dawei Yang,Yuguo Tang,Zhenzhen Guo et al.
Dawei Yang et al.
A novel electrochemical aptasensor for the detection of trace protein is proposed based on proximity binding-induced strand displacement and hybridization chain reaction. This method is proven to be highly selective and has potential practi...
Julie Stockis,Olivier Dedobbeleer,Sophie Lucas
Julie Stockis
TGF-β1, 2 and 3 cytokines are involved in many cellular processes including cell proliferation, differentiation, migration and survival. Whereas TGF-β2 and 3 play important roles in embryonic development, TGF-β1 is mostly implicated in c...
Restoring calcium homeostasis in diabetic cardiomyocytes: an investigation through mathematical modelling [0.03%]
糖尿病心肌细胞钙稳态的恢复：通过数学建模进行的研究
Phonindra Nath Das,Ajay Kumar,Nandadulal Bairagi et al.
Phonindra Nath Das et al.
Calcium homeostasis is a key factor in the regulation of cardiac excitation-contraction coupling. Calcium dynamics in cardiomyocytes is governed by ATP which depends on insulin dependent glucose concentration, via the glucose transporter ty...
Murine cutaneous leishmaniasis investigated by MALDI mass spectrometry imaging [0.03%]
基质辅助激光解析电离-飞行时间质谱成像技术在研究小鼠皮肤利什曼病中的应用
Fernanda Negrão,Daniele F de O Rocha,Caroline F Jaeeger et al.
Fernanda Negrão et al.
Imaging mass spectrometry (IMS) is recognized as a powerful tool to investigate the spatial distribution of untargeted or targeted molecules of a wide variety of samples including tissue sections. Leishmania is a protozoan parasite that cau...
Protein intrinsic disorder negatively associates with gene age in different eukaryotic lineages [0.03%]
真核生物中蛋白质内在无序与基因年龄呈负相关性
Sanghita Banerjee,Sandip Chakraborty
Sanghita Banerjee
The emergence of new protein-coding genes in a specific lineage or species provides raw materials for evolutionary adaptations. Until recently, the biology of new genes emerging particularly from non-genic sequences remained unexplored. Alt...
Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population [0.03%]
新西兰人口中老化及与侵袭性前列腺癌风险相关的单核苷酸多态性的影响
Venkatesh Vaidyanathan,Vijay Naidu,Nishi Karunasinghe et al.
Venkatesh Vaidyanathan et al.
Prostate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role...
Global DNA dynamics of 8-oxoguanine repair by human OGG1 revealed by stopped-flow kinetics and molecular dynamics simulation [0.03%]
全局停流动力学和分子动力学模拟揭示的人类OGG1修复8-氧鸟嘌呤的DNA动态机制研究
M V Lukina,V V Koval,A A Lomzov et al.
M V Lukina et al.
The toxic action of different endogenous and exogenous agents leads to damage in genomic DNA. 8-Oxoguanine is one of the most often generated and highly mutagenic oxidative forms of damage in DNA. Normally, in human cells it is promptly rem...