A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells [0.03%]
利用系统生物学方法鉴定顺铂耐药的人卵巢癌细胞中的微小核糖核酸
Weisha Liu,Shuyuan Wang,Shunheng Zhou et al.
Weisha Liu et al.
Cisplatin (CDDP)-based chemotherapy is a standard first-line therapy for ovarian cancer. However, drug resistance remains a major obstacle to its efficacy. Recently, increasing evidence suggested that the aberrant expression of microRNAs (m...
mRNA-miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation [0.03%]
用于预测结直肠癌分期差异的预后模块生物标志物的mRNA-miRNA二分网络重构
Habib Motieghader,Morteza Kouhsar,Ali Najafi et al.
Habib Motieghader et al.
Biomarker detection is one of the most important and challenging problems in cancer studies. Recently, non-coding RNA based biomarkers such as miRNA expression levels have been used for early diagnosis of many cancer types. In this study, a...
An immunoinformatics approach to promiscuous peptide design for the Plasmodium falciparum erythrocyte membrane protein-1 [0.03%]
一种针对恶性疟原虫红细胞膜蛋白-1的免疫信息学方法设计通用肽
Nazam Khan,Rajender Kumar,Shakti Chauhan et al.
Nazam Khan et al.
Plasmodium falciparum erythrocyte membrane protein-1 (Pfemp-1), a variant adhesion molecule, can act as a key component of immunity against malaria. In the current selection of malaria vaccines, no efficient vaccines are available that can ...
Effects of flexibility and electrostatic interactions on the coupled binding-folding mechanisms of Chz.core and H2A.z-H2B [0.03%]
柔韧性与静电相互作用对Chz.core及H2A.z-H2B耦合结合-折叠机制的影响
Xu Shang,Wenting Chu,Xiakun Chu et al.
Xu Shang et al.
The intrinsically disordered protein (IDP) Chz.core, which is the interaction core of Chz1, shows binding preference to histone variant H2A.z. Although there are several studies on the binding process of Chz.core, the detailed coupled bindi...
Rational design of an orthogonal noncovalent interaction system at the MUPP1 PDZ11 complex interface with CaMKIIα-derived peptides in human fertilization [0.03%]
人受精过程中在MUPP1 PDZ11复合物界面与CaMKIIα衍生肽相互作用的正交非共价作用系统理性设计
Yi-Le Zhang,Zhao-Feng Han
Yi-Le Zhang
The recognition and association between the Ca2+/calmodulin-activated protein kinase II-α (CaMKIIα) and the multi-PDZ domain protein 1 (MUPP1) plays an important role in the sperm acrosome reaction and human fertilization. Previously, we ...
RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel [0.03%]
基于RNA测序技术解析顺铂联合紫杉醇和多西他赛耐药性多倍体癌细胞转录组
Qianqian Wang,Fei Lu,Rongfeng Lan
Qianqian Wang
Overcoming chemoresistance will prevent cancer relapse and contribute to clinical chemotherapy. In order to explore the underlying mechanism of chemoresistance, we firstly incubated cancer cells with a combination of cisplatin + paclitaxel ...
Discovering potential driver genes through an integrated model of somatic mutation profiles and gene functional information [0.03%]
基于基因功能信息的体细胞突变谱整合模型揭示潜在驱动基因
Jianing Xi,Minghui Wang,Ao Li
Jianing Xi
The accumulating availability of next-generation sequencing data offers an opportunity to pinpoint driver genes that are causally implicated in oncogenesis through computational models. Despite previous efforts made regarding this challengi...
CXCR7 attenuates the TGF-β-induced endothelial-to-mesenchymal transition and pulmonary fibrosis [0.03%]
CXCR7通过抑制TGF-β诱导的内皮间质转化减轻肺纤维化
Shuhong Guan,Jun Zhou
Shuhong Guan
Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast proliferation and excessive deposition of extracellular matrix in the lungs. The chemokine receptor CXCR7 has been shown to control cell adhesion, migra...
A cross-platform metabolomics workflow for volume-restricted tissue samples: application to an animal model for polycystic kidney disease [0.03%]
一种用于体积受限性组织样本的跨平台代谢组学工作流程及其在多囊肾病动物模型中的应用
E Sánchez-López,H Happé,E Steenvoorden et al.
E Sánchez-López et al.
Metabolic profiling provides an unbiased view of the physiological status of an organism as a "function" of the metabolic composition of a measured sample. Here, we propose a simple LC-MS based workflow for metabolic profiling of volume-res...
Comprehensive analysis of long noncoding RNA-mRNA co-expression patterns in thyroid cancer [0.03%]
甲状腺癌中长链非编码RNA与mRNA共表达模式的全面分析
Yaying Du,Wenfei Xia,Jinjun Zhang et al.
Yaying Du et al.
Novel molecular-targeted treatments show great prospects for radioiodine-refractory and surgically inoperable thyroid carcinomas. While aberrations in protein-coding genes are a focus in molecular thyroid cancer medicine, the impact of onco...