Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms [0.03%]
基于网络的建模和渗析分析探讨CDK2和CDK4蛋白构象动态及活化：激酶亚基的动态和能量极化可能决定了调控机制的分化
G M Verkhivker
G M Verkhivker
The overarching goal of delineating molecular principles underlying differentiation of the activation mechanisms in cyclin-dependent kinases (CDKs) is important for understanding regulatory divergences among closely related kinases which ca...
A novel method for identifying potential disease-related miRNAs via a disease-miRNA-target heterogeneous network [0.03%]
基于疾病-微小核糖核酸-靶标异构网络的潜在疾病相关微小核糖核酸识别新方法研究
Liang Ding,Minghui Wang,Dongdong Sun et al.
Liang Ding et al.
MicroRNAs (miRNAs), as a kind of important small endogenous single-stranded non-coding RNA, play critical roles in a large number of human diseases. However, the currently known experimental verifications of the disease-miRNA associations a...
HIV/HAART-associated oxidative stress is detectable by metabonomics [0.03%]
HIV/HAART相关氧化压力的代谢组学检测方法
Aurelia A Williams,Lungile J Sitole,Debra Meyer
Aurelia A Williams
Chronic human immunodeficiency virus (HIV) infection, separately and in combination with highly active antiretroviral therapy (HAART) is closely associated with oxidative stress (OS). Most studies demonstrating redox imbalances in HIV-infec...
Real-time activity assays of β-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains [0.03%]
β-内酰胺酶在活细菌细胞中的实时活性测定及其在抑制抗生素耐药性大肠杆菌菌株方面的应用
Ying Ge,Ya-Jun Zhou,Ke-Wu Yang et al.
Ying Ge et al.
The emergence of antibiotic resistance caused by β-lactamases, including serine β-lactamases (SβLs) and metallo-β-lactamases (MβLs), is a global public health threat. L1, a B3 subclass MβL, hydrolyzes almost all of known β-lactam ant...
Enantioselective recognition of an isomeric ligand by a biomolecule: mechanistic insights into static and dynamic enantiomeric behavior and structural flexibility [0.03%]
手性底物的对映选择性识别及分子机械行为研究：静态与动态拆分和结构柔韧性的见解
Wei Peng,Fei Ding
Wei Peng
Chirality is a ubiquitous basic attribute of nature, which inseparably relates to the life activity of living organisms. However, enantiomeric differences have still failed to arouse enough attention during the biological evaluation and pra...
Correction: An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by combined machine learning and molecular pathway analysis [0.03%]
纠正：结合机器学习和分子途径分析的温心颗粒抗心律失常作用整合靶点网络研究
Taiyi Wang,Ming Lu,Qunqun Du et al.
Taiyi Wang et al.
Correction for 'An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis' by Taiyi Wang et al., Mol. BioSyst., 2017, 13, 1018-1030.
Published Erratum
Molecular bioSystems. 2017 Sep 26;13(10):2181. DOI:10.1039/c7mb90035j 2017
Computational study on the origin of the cancer immunotherapeutic potential of B and T cell epitope peptides [0.03%]
计算研究B和T细胞表位肽癌症免疫治疗潜力的起源
Hao Li,Nalini Schaduangrat,Saw Simeon et al.
Hao Li et al.
Immune therapy is generally seen as the future of cancer treatment. The discovery of tumor-associated antigens and cytotoxic T lymphocyte epitope peptides spurned intensive research into effective peptide-based cancer vaccines. One of the m...
Mass spectrometry based identification of galectin-3 interacting proteins potentially involved in lung melanoma metastasis [0.03%]
基于质量谱的半乳糖凝集素-3相互作用蛋白的识别及其在肺癌黑色素瘤转移中的潜在作用
Manohar C Dange,Hemangi S Bhonsle,Rashmi K Godbole et al.
Manohar C Dange et al.
Adhesive interactions between molecules on tumor cells and those on target organs play a key role in organ specific metastasis. Poly-N-acetyl-lactosamine (polyLacNAc) substituted N-oligosaccharides on melanoma cell surface glycoproteins pro...
MicroRNAs regulate the main events in rice drought stress response by manipulating the water supply to shoots [0.03%]
微小核糖核酸通过调控水稻干旱应答过程中的供水情况来调节主要干旱响应事件
Ehsan Mohseni Fard,Behnam Bakhshi,Mohammad Farsi et al.
Ehsan Mohseni Fard et al.
MicroRNAs (miRNAs) are small endogenous regulatory RNAs that are involved in a variety of biological processes related to proliferation, development, and response to biotic and abiotic stresses. miRNA profiles of rice (Oryza sativa L. cv. I...
Investigation of a common gene expression signature in gastrointestinal cancers using systems biology approaches [0.03%]
采用系统生物学方法研究胃肠类癌症中常见的基因表达特征
Kaveh Baghaei,Nazanin Hosseinkhan,Hamid Asadzadeh Aghdaei et al.
Kaveh Baghaei et al.
According to GLOBOCAN 2012, the incidence and the mortality rate of colorectal, stomach and liver cancers are the highest among the total gastrointestinal (GI) cancers. Here we aimed to find the common genes and pathways that are simultaneo...