Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study [0.03%]
Bacteroides thetaiotaomicron 二肽基肽酶III的动力学性质及其底物特异性的结构基础——一项计算研究
M Tomin,S Tomić
M Tomin
Dipeptidyl peptidase III (DPP III) from the human gut symbiont Bacteroides thetaiotaomicron (Bt) is the first identified prokaryotic DPP III orthologue. It has low sequence similarity to the thoroughly studied human DPP III, and differently...
Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library [0.03%]
筛选甘露糖修饰的α-螺旋肽噬菌体库中的刀豆蛋白A结合肽
Iou Ven Chang,Hiroshi Tsutsumi,Hisakazu Mihara
Iou Ven Chang
Mannose-modified lectin-binding peptides were obtained from an α-helical-designed peptide phage library. Concanavalin A (ConA) was used as a representative target protein for the lectin family. The identified glycopeptides could selectivel...
Lipidomic alterations of in vitro macrophage infection by L. infantum and L. amazonensis [0.03%]
利什曼原虫体外感染巨噬细胞的脂质组学变化分析
Fernanda Negrão,Daniel R Abánades,Caroline F Jaeeger et al.
Fernanda Negrão et al.
Particular lipid profiles have been found in two different protozoa of the Leishmania genus. Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid conte...
Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients [0.03%]
代谢组学揭示线粒体及脂肪酸代谢障碍促进2型糖尿病患者糖尿病肾病发展的机制
Ling Li,Chengshi Wang,Hongliu Yang et al.
Ling Li et al.
Diabetic kidney disease (DKD) is the leading cause of ESRD; however, early intervention can greatly prevent the progression of DKD; thus, sensitive biomarkers for DKD are still required. This study was aimed at the identification of potenti...
Modelling the propagation of a dynamical signature in gene expression mediated by the transport of extracellular microRNAs [0.03%]
利用细胞外microRNAs的运输建立基因表达中动力学签名传播的模型
Alexis Grau Ribes,Yannick De Decker,Claude Gérard et al.
Alexis Grau Ribes et al.
Extracellular microRNAs (miRNAs) carried by exosomes can play a key role in cell-to-cell communication. Deregulation of miRNA expression and exosome secretion have been related to pathological conditions such as cancer. While it is known th...
Identification of a suitable promoter for the sigma factor of Mycobacterium tuberculosis [0.03%]
鉴定适用于结核分枝杆菌σ因子的启动子
A Mallick Gupta,S Mukherjee,A Dutta et al.
A Mallick Gupta et al.
Promoter binding specificity is one of the important characteristics of transcription by Mycobacterium tuberculosis (Mtb) sigma (σ) factors, which remains unexplored due to limited structural evidence. Our previous study on the structural ...
CarSite: identifying carbonylated sites of human proteins based on a one-sided selection resampling method [0.03%]
基于单面选择重采样方法的人类蛋白质酮基化位点识别(carSite)
Yun Zuo,Cang-Zhi Jia
Yun Zuo
Protein carbonylation is one of the most important biomarkers of oxidative protein damage and such protein damage is linked to various diseases and aging. It is thus vital that carbonylation sites are identified accurately. In this study, C...
Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer [0.03%]
长链非编码RNA SNHG17通过表观遗传学沉默P57在结直肠癌中发挥不良预后作用和促进细胞增殖的作用
Zhonghua Ma,Shengying Gu,Min Song et al.
Zhonghua Ma et al.
Recently, substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in multiple cancers including colorectal cancer (CRC). Utilizing publicly available lncRNA-expression-profiling data from the Gene Expre...
Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes [0.03%]
渗透压胁迫下哺乳动物细胞的非完全拥挤适应及其通过渗透调节分子进行的调控
David Gnutt,Oliver Brylski,Eugen Edengeiser et al.
David Gnutt et al.
Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmoti...
Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis [0.03%]
甲基甘油醛能减弱胰岛素信号并下调胆固醇生物合成相关酶的功能
Arati B Deshmukh,Shakuntala Bai,Aarthy T et al.
Arati B Deshmukh et al.
Methylglyoxal (MG) is a highly reactive dicarbonyl known to be elevated under the hyperglycemic conditions of diabetes and is implicated in the development of diabetic complications. Therefore, the current study investigates the role of MG ...