Protein-protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms [0.03%]
从新的视角评估电压依赖性 ан-通道同工型不同的功能作用：蛋白质-蛋白质相互作用网络
Marianna Caterino,Margherita Ruoppolo,Annalisa Mandola et al.
Marianna Caterino et al.
Voltage-dependent anion channels (VDACs) are a family of three mitochondrial porins and the most abundant integral membrane proteins of the mitochondrial outer membrane (MOM). VDACs are known to be involved in metabolite/ion transport acros...
Prediction of drug-pathway interaction pairs with a disease-combined LSA-PU-KNN method [0.03%]
一种预测药物-途径相互作用对的疾病结合LSA-PU-KNN方法
Fan-Shu Chen,Hui-Yan Jiang,Zhenran Jiang
Fan-Shu Chen
Prediction of new associations between drugs and targeting pathways can provide valuable clues for drug discovery & development. However, information integration and a class-imbalance problem are important challenges for available predictio...
MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24 [0.03%]
microRNA-590-5p通过靶向ARHGAP24调节肾细胞癌细胞系的活力、凋亡、迁移和侵袭能力
Lei Wang,Wan-Qing Wei,Zi-Yu Wu et al.
Lei Wang et al.
Renal cell carcinoma (RCC) is the leading cause of death in renal malignancies. MicroRNA-590-5p (miR-590-5p) is of great importance in the processes of many cancers regarding regulation of cancer cell invasion and proliferation. In our stud...
Evaluation and optimization of reduction and alkylation methods to maximize peptide identification with MS-based proteomics [0.03%]
评估和优化还原和烷基化方法以最大限度地提高基于质谱的蛋白质组学中的肽鉴定
Suttipong Suttapitugsakul,Haopeng Xiao,Johanna Smeekens et al.
Suttipong Suttapitugsakul et al.
Mass spectrometry (MS) has become an increasingly important technique to analyze proteins. In popular bottom-up MS-based proteomics, reduction and alkylation are routine steps to facilitate peptide identification. However, incomplete reacti...
Role of solvent properties of water in crowding effects induced by macromolecular agents and osmolytes [0.03%]
水的溶剂性质在大分子和渗透压效应诱导的拥挤效应中的作用
L A Ferreira,V N Uversky,B Y Zaslavsky
L A Ferreira
Solvent properties of water in aqueous solutions of polyethylene glycols of various molecular weights, l-proline, betaine, and a series of chlorides of varied concentrations are assayed using three solvatochromic dyes. The properties includ...
Computational identification of protein S-sulfenylation sites by incorporating the multiple sequence features information [0.03%]
基于多序列特征信息的蛋白质S-硫烯基化位点计算识别方法
Md Mehedi Hasan,Dianjing Guo,Hiroyuki Kurata
Md Mehedi Hasan
Cysteine S-sulfenylation is a major type of posttranslational modification that contributes to protein structure and function regulation in many cellular processes. Experimental identification of S-sulfenylation sites is challenging, due to...
Wenran Li,Meng Wang,Jinghao Sun et al.
Wenran Li et al.
Genome sequencing technology has generated a vast amount of genomic and epigenomic data, and has provided us a great opportunity to study gene functions on a global scale from an epigenomic view. In the last decade, network-based studies, s...
PANDAR: a pivotal cancer-related long non-coding RNA in human cancers [0.03%]
PANDAR：人类癌症中的一个关键癌基因长链非编码RNA
Jinglin Li,Zhenglong Li,Wangyang Zheng et al.
Jinglin Li et al.
Long non-coding RNAs (lncRNAs), non-protein-coding RNAs that are more than 200 nucleotides in length, have been demonstrated to play a vital role in the pathophysiology of human diseases, particularly in tumorigenesis and progression of can...
The Henipavirus V protein is a prevalently unfolded protein with a zinc-finger domain involved in binding to DDB1 [0.03%]
henipavirus v蛋白是一种含有与Ddb1结合的锌指结构域的主要无序蛋白
Edoardo Salladini,Vincent Delauzun,Sonia Longhi
Edoardo Salladini
Henipaviruses are severe human pathogens within the Paramyxoviridae family. Beyond the P protein, the Henipavirus P gene also encodes the V protein which shares with P its N-terminal, intrinsically disordered region (PNT) and possesses a un...
A computational method using differential gene expression to predict altered metabolism of multicellular organisms [0.03%]
一种利用差异基因表达预测多细胞生物代谢变化的计算方法
Lvxing Zhu,Haoran Zheng,Xinying Hu et al.
Lvxing Zhu et al.
Altered metabolism is often identified as a cause or an effect of physiology and pathogenesis. But it is difficult to predict the metabolic flux distributions of multicellular organisms due to the lack of an explicit metabolic objective fun...