Hybrid deterministic/stochastic simulation of complex biochemical systems [0.03%]
复杂生化系统杂合确定量/概率仿真方法研究进展及软件实现
Paola Lecca,Fabio Bagagiolo,Marina Scarpa
Paola Lecca
In a biological cell, cellular functions and the genetic regulatory apparatus are implemented and controlled by complex networks of chemical reactions involving genes, proteins, and enzymes. Accurate computational models are indispensable m...
The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage [0.03%]
核小体表面是DNA损伤反应中组蛋白ADP-核糖基化的主要靶点
Kelly R Karch,Marie-France Langelier,John M Pascal et al.
Kelly R Karch et al.
ADP-ribosylation is a protein post-translational modification catalyzed by ADP-ribose transferases (ARTs). ART activity is critical in mediating many cellular processes, and is required for DNA damage repair. All five histone proteins are e...
NARRMDA: negative-aware and rating-based recommendation algorithm for miRNA-disease association prediction [0.03%]
基于负样本和评分的微小核糖核酸-疾病关联预测算法
Lihong Peng,Yeqing Chen,Ning Ma et al.
Lihong Peng et al.
An increasing amount of evidence indicates that microRNAs (miRNAs) are closely related to many important biological processes and play a significant role in various human diseases. More and more researchers have begun to seek effective meth...
Insights into human intrinsically disordered proteins from their gene expression profile [0.03%]
人类固有无序蛋白的基因表达特征分析
Arup Panda,Debarun Acharya,Tapash Chandra Ghosh
Arup Panda
Expression level provides important clues about gene function. Previously, various efforts have been undertaken to profile human genes according to their expression level. Intrinsically disordered proteins (IDPs) do not adopt any rigid conf...
Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1 [0.03%]
人单链选择性单功能尿嘧啶-DNA糖基化酶SMUG1的损伤识别的预平衡动力学分析
Alexandra A Kuznetsova,Danila A Iakovlev,Inna V Misovets et al.
Alexandra A Kuznetsova et al.
In all organisms, DNA glycosylases initiate base excision repair pathways resulting in removal of aberrant bases from DNA. Human SMUG1 belongs to the superfamily of uracil-DNA glycosylases catalyzing the hydrolysis of the N-glycosidic bond ...
Methods for monitoring and measurement of protein translation in time and space [0.03%]
时空蛋白质翻译监测和测量方法
Maria Dermit,Martin Dodel,Faraz K Mardakheh
Maria Dermit
Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison to transcriptional regulation, however, translational control has remained a significantly under-studied layer of gene expression. Thi...
Molecular dynamics simulations of β2-microglobulin interaction with hydrophobic surfaces [0.03%]
β2-微球蛋白与疏水表面相互作用的分子动力学模拟
Cedrix J Dongmo Foumthuim,Alessandra Corazza,Gennaro Esposito et al.
Cedrix J Dongmo Foumthuim et al.
Hydrophobic surfaces are known to adsorb and unfold proteins, a process that has been studied only for a few proteins. Here we address the interaction of β2-microglobulin, a paradigmatic protein for the study of amyloidogenesis, with hydro...
Hedgehog-mesenchyme gene signature identifies bi-modal prognosis in luminal and basal breast cancer sub-types [0.03%]
刺猬组织基因表达谱可识别乳癌 Luminal 和 Basal 型的双相预后
Wandaliz Torres-García,Maribella Domenech
Wandaliz Torres-García
Hedgehog signaling (Hh) has been shown to be hyper-activated in several cancers. However, active Hh signaling can promote or inhibit tumor growth; thus identification of markers beyond main canonical Hh target genes is needed to improve pat...
Exploring the role of GS-GOGAT cycle in microcystin synthesis and regulation - a model based analysis [0.03%]
基于模型的GS-GOGAT循环在微囊藻毒素合成和调控中的作用研究
Swarnendu Banerjee,Abhishek Subramanian,Joydev Chattopadhyay et al.
Swarnendu Banerjee et al.
Toxic cyanobacteria blooms populate water bodies by consuming external nutrients and releasing cyanotoxins that are detrimental for other aquatic species, producing a significant impact on the plankton ecosystem and food web. To exercise po...
A Bayesian approach for estimating protein-protein interactions by integrating structural and non-structural biological data [0.03%]
一种整合结构及非结构生物学数据估算蛋白质间相互作用的贝叶斯方法
Hafeez Ur Rehman,Inam Bari,Anwar Ali et al.
Hafeez Ur Rehman et al.
Accurate elucidation of genome wide protein-protein interactions is crucial for understanding the regulatory processes of the cell. High-throughput techniques, such as the yeast-2-hybrid (Y2H) assay, co-immunoprecipitation (co-IP), mass spe...