Proteomic analysis of prognostic plasma biomarkers in peripheral arterial occlusive disease [0.03%]
外周动脉阻塞病预后血浆生物标志物的蛋白质组分析
Cheng-San Yang,Yu-Shan Wei,Han-Lin Tsai et al.
Cheng-San Yang et al.
Peripheral arterial occlusive disease (PAOD), one of the major manifestations of systemic atherosclerosis, causes intermittent claudication and rest pain. Patients with PAOD not only have reduced quality of life, but also have a substantial...
FOCuS: a metaheuristic algorithm for computing knockouts from genome-scale models for strain optimization [0.03%]
用于基因尺度模型菌株优化的计算敲除的元启发式算法FOCuS
Sarma Mutturi
Sarma Mutturi
Although handful tools are available for constraint-based flux analysis to generate knockout strains, most of these are either based on bilevel-MIP or its modifications. However, metaheuristic approaches that are known for their flexibility...
Correction: Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients [0.03%]
纠正：子宫内膜异位症患者卵泡液的代谢组学分析和生化评估
Marianna Santonastaso,Alessia Pucciarelli,Susan Costantini et al.
Marianna Santonastaso et al.
Correction for 'Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients' by Marianna Santonastaso et al., Mol. BioSyst., 2017, DOI: 10.1039/c7mb00181a.
Published Erratum
Molecular bioSystems. 2017 May 30;13(6):1246. DOI:10.1039/c7mb90021j 2017
Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-κB and FGF2 [0.03%]
microRNA-302d和microRNA-16通过靶向NF-κB和FGF2抑制人类多形性胶质母细胞瘤
Feng Wang,Lijun Yang,Jianping Sun et al.
Feng Wang et al.
Glioblastoma multiforme (GBM) is a highly malignant cancer in the brain with a median survival time of approximately one year. However, the mechanisms underlying GBM development and occurrence are poorly understood. Recently, miRNAs were re...
Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks [0.03%]
细胞外囊泡的涌现特性：采用整体方法解码细胞间通讯网络的复杂性
Yong Song Gho,Changjin Lee
Yong Song Gho
Shedding of nano-sized bilayered extracellular vesicles and extracellular vesicle-mediated intercellular communication are evolutionarily conserved biological processes. Communication between cells and the environment is an essential proces...
GeneSPIDER - gene regulatory network inference benchmarking with controlled network and data properties [0.03%]
GeneSPIDER-具有可控网络和数据属性的基因调控网络推理基准测试
Andreas Tjärnberg,Daniel C Morgan,Matthew Studham et al.
Andreas Tjärnberg et al.
A key question in network inference, that has not been properly answered, is what accuracy can be expected for a given biological dataset and inference method. We present GeneSPIDER - a Matlab package for tuning, running, and evaluating inf...
Systematic comparison of the response properties of protein and RNA mediated gene regulatory motifs [0.03%]
系统比较由蛋白质和RNA介导的基因调控模式的响应特性
Bharat Ravi Iyengar,Beena Pillai,K V Venkatesh et al.
Bharat Ravi Iyengar et al.
We present a framework enabling the dissection of the effects of motif structure (feedback or feedforward), the nature of the controller (RNA or protein), and the regulation mode (transcriptional, post-transcriptional or translational) on t...
Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics [0.03%]
分子动力学揭示的结核分支杆菌中l,d-转肽酶2的不同翻盖动态特性
Zeynab Fakhar,Thavendran Govender,Glenn E M Maguire et al.
Zeynab Fakhar et al.
Despite the advances in tuberculosis treatment, TB is still one the most deadly infectious diseases and remains a major global health quandary. Mycobacterium tuberculosis (Mtb) is the only known mycobacterium with a high content of 3→3 cro...
Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients [0.03%]
代谢组学谱分析和内异症患者卵泡液生化评价
Santonastaso Marianna,Pucciarelli Alessia,Costantini Susan et al.
Santonastaso Marianna et al.
Diseases are complex systems that can be studied through the integration of data derived from different disciplines to obtain a global and reliable picture of the biological phenomenon under investigation. Based on the recent observations t...
Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling [0.03%]
分子建模表征人NPP1自由形式和底物结合复合物的结构、动力学和别构途径
Xavier Barbeau,Patrick Mathieu,Jean-François Paquin et al.
Xavier Barbeau et al.
The ectonucleotide phosphodiesterase/pyrophosphatase-1 (NPP1) is a type II transmembrane glycoprotein that regulates extracellular inorganic purine nucleotide and inorganic diphosphate levels through the hydrolysis of ATP into AMP and dipho...