Structure-based design of novel combinatorially generated NBTIs as potential DNA gyrase inhibitors against various Staphylococcus aureus mutant strains [0.03%]
基于结构的新型NBTI组合生成设计作为各种金黄色葡萄球菌突变株的DNA回旋酶抑制剂的潜在候选物
Anja Kolaric,Nikola Minovski
Anja Kolaric
Although intercalating agents such as quinolones have had proven therapeutic success as antibacterial agents for more than 40 years, new forms of quinolone-based resistance in bacteria are continually emerging. To alleviate this problem, a ...
Literature-based prediction of novel drug indications considering relationships between entities [0.03%]
基于实体间关系的新型药物适应症文献研究
Giup Jang,Taekeon Lee,Byung Mun Lee et al.
Giup Jang et al.
There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. Among these efforts, text mining is an effective means of discovering novel knowledge from a large amount of literature...
Mathematical modeling reveals differential regulation of MAPK activity by phosphatase proteins in the yeast pheromone response pathway [0.03%]
数学建模揭示MAPK在酵母激素响应途径中由磷蛋白酶差别的调节作用
Nathan Dyjack,Cassandra Azeredo-Tseng,Necmettin Yildirim
Nathan Dyjack
To prevent indefinite cellular responses to external signals, cells utilize various adaptation mechanisms. The yeast mating-response pathway is a model cellular system that exhibits adaptation to persistent external signals. This pathway em...
Damien Nicolas,Nick E Phillips,Felix Naef
Damien Nicolas
Isogenic cells in a common environment present a large degree of heterogeneity in gene expression. Part of this variability is attributed to transcriptional bursting: the stochastic activation and inactivation of promoters that leads to the...
The effect of global transcriptional regulators on the anaerobic fermentative metabolism of Escherichia coli [0.03%]
全局转录调控因子对大肠杆菌厌氧发酵代谢的影响
Manika Kargeti,K V Venkatesh
Manika Kargeti
Global transcription factors are known to regulate the anaerobic growth of Escherichia coli on glucose. These transcription factors help the organism to sense oxygen and accordingly regulate the synthesis of mixed acid producing enzymes. Fi...
Dynamic properties of the growth hormone releasing hormone receptor (GHRHR) and molecular determinants of GHRH binding [0.03%]
生长激素释放激素受体（GHRHR）的动力学特性及GHRH结合的分子决定因素
M-T Matsoukas,G A Spyroulias
M-T Matsoukas
The growth hormone-releasing hormone receptor (GHRHR) is a member of the class B GPCR subfamily. GHRH, a 44-residue neuropeptide produced in the hypothalamus, regulates the secretion of growth hormone through its binding to GHRHR. It has re...
vhfRNAi: a web-platform for analysis of host genes involved in viral infections discovered by genome wide RNAi screens [0.03%]
VhfRNAi：一个分析病毒感染中涉及宿主基因的网页平台，该平台由全基因组RNAi筛选发现
Anamika Thakur,Abid Qureshi,Manoj Kumar
Anamika Thakur
Knockdown of host genes using high-throughput genome-wide RNA interference screens has identified numerous host factors that affect viral infections, which would be helpful in understanding host-virus interactions. We have developed a vhfRN...
Crystal structure of Aquifex aeolicus gene product Aq1627: a putative phosphoglucosamine mutase reveals a unique C-terminal end-to-end disulfide linkage [0.03%]
硫化叶热菌Aq1627蛋白的晶体结构：一个假定的磷酰葡萄糖胺异构酶含有独特的C端端到端二硫键连接
Upasana Sridharan,Seiki Kuramitsu,Shigeyuki Yokoyama et al.
Upasana Sridharan et al.
The Aq1627 gene from Aquifex aeolicus, a hyperthermophilic bacterium has been cloned and overexpressed in Escherichia coli. The protein was purified to homogeneity and its X-ray crystal structure was determined to 1.3 Å resolution using mu...
Structure based in silico identification of potentially non-steroidal brassinosteroids mimics [0.03%]
基于结构的 brassinosteroid 类似物的计算机虚拟筛选及鉴定
Beilei Lei,Ningjuan Heng,Xiaoxue Dang et al.
Beilei Lei et al.
Brassinosteroids (BRs) are a class of plant steroid hormones that play indispensable roles in cell elongation, division and plant development. To date, the numerous synthesis of BRs analogs and structure-activity relationship investigations...
Kasi Viswanatharaju Ruddraraju,Zhong-Yin Zhang
Kasi Viswanatharaju Ruddraraju
Protein tyrosine phosphatases (PTPs) are a large family of 107 signaling enzymes that catalyze the hydrolytic removal of phosphate groups from tyrosine residues in a target protein. The phosphorylation status of tyrosine residues on protein...