Phosphorylation of a full length amyloid-β peptide modulates its amyloid aggregation, cell binding and neurotoxic properties [0.03%]
全长淀粉样蛋白-β的磷酸化修饰调控其淀粉样聚集、细胞粘附和神经毒性性质
Elaheh Jamasbi,Frances Separovic,Mohammed Akhter Hossain et al.
Elaheh Jamasbi et al.
Amyloid beta peptide (Aβ) is the major protein component of the amyloid plaques that are present in the brains of Alzheimer's disease (AD) patients. Aβ42 peptide is a known neurotoxic agent that binds to neurons and, under specific aggreg...
Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence [0.03%]
组氨酸突变影响人类酪氨酶结构稳定性导致白化病的计算分析研究
Mubashir Hassan,Qamar Abbas,Hussain Raza et al.
Mubashir Hassan et al.
Misfolding and structural alteration in proteins lead to serious malfunctions and cause various diseases in humans. Mutations at the active binding site in tyrosinase impair structural stability and cause lethal albinism by abolishing coppe...
Decoding the regulatory mechanism of glucose and insulin induced phosphatidylinositol 3,4,5-trisphosphate dynamics in β-cells [0.03%]
解析葡萄糖和胰岛素诱导的β细胞中磷脂酰肌醇(3,4,5)三磷酸动力学调控机制
Tagari Samanta,Peeyush Sharma,Dwijendra Kukri et al.
Tagari Samanta et al.
In MIN6 pancreatic β-cells, glucose and insulin act in a synergistic manner to regulate the dynamics of Phosphatidylinositol (3,4,5)-trisphosphate (PIP3). However, the precise regulatory mechanism behind such an experimentally observed syn...
Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age [0.03%]
儿童肥胖相关基因变异分析
Mohanraj Krishnan,John M D Thompson,Edwin A Mitchell et al.
Mohanraj Krishnan et al.
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights int...
Proteomic analysis reveals Xuesaitong injection attenuates myocardial ischemia/reperfusion injury by elevating pyruvate dehydrogenase-mediated aerobic metabolism [0.03%]
蛋白组学分析发现速泰注射液通过提高有氧代谢关键酶丙酮酸脱氢酶活性来改善心肌缺血再灌注损伤
Xiaoping Zhao,Feng Zhang,Yi Wang
Xiaoping Zhao
Xuesaitong injection (XST), which mainly consists of Panax notoginseng saponins, has been widely used for treating cardio-cerebral vascular diseases. However, the underlying mechanisms of XST associated with its cardioprotective effects are...
Luz M Meneghini,Sarvind Tripathi,Marcus A Woodworth et al.
Luz M Meneghini et al.
Membrane proteins (MPs) constitute a third of all proteomes, and contribute to a myriad of cellular functions including intercellular communication, nutrient transport and energy generation. For example, TonB-dependent transporters (TBDTs) ...
Computational investigation of the human SOD1 mutant, Cys146Arg, that directs familial amyotrophic lateral sclerosis [0.03%]
人源SOD1突变体Cys146Arg的计算研究可指导家族性肌萎缩侧索硬化症
E Srinivasan,R Rajasekaran
E Srinivasan
The genetic substitution mutation of Cys146Arg in the SOD1 protein is predominantly found in the Japanese population suffering from familial amyotrophic lateral sclerosis (FALS). A complete study of the biophysical aspects of this particula...
Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR [0.03%]
脆性X综合症智力障碍蛋白识别Survival Motor Neuron 区域1 mRNA的5'非翻译区内的G四链体结构
Damian S McAninch,Ashley M Heinaman,Cara N Lang et al.
Damian S McAninch et al.
G quadruplex structures have been predicted by bioinformatics to form in the 5'- and 3'-untranslated regions (UTRs) of several thousand mature mRNAs and are believed to play a role in translation regulation. Elucidation of these roles has p...
Predicting protein-protein interactions from protein sequences by a stacked sparse autoencoder deep neural network [0.03%]
基于堆叠的稀疏自动编码深度神经网络的蛋白质相互作用预测方法
Yan-Bin Wang,Zhu-Hong You,Xiao Li et al.
Yan-Bin Wang et al.
Protein-protein interactions (PPIs) play an important role in most of the biological processes. How to correctly and efficiently detect protein interaction is a problem that is worth studying. Although high-throughput technologies provide t...
Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach [0.03%]
基于整合方法鉴定养心氏片中保护人类诱导多能干细胞源性心肌细胞心脏功能的活性成分
Minyu Zhang,Hongwei Wu,Feifei Guo et al.
Minyu Zhang et al.
Traditional Chinese medicine (TCM) preparations have significant effects on some refractory diseases; however, these compositions are complex and their mechanisms are unknown. Identification of the active components in these preparations is...