Domenica Capasso,Sonia Di Gaetano,Veronica Celentano et al.
Domenica Capasso et al.
The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. With the perspective of finding novel proangiogenic molecules, we searched peptide sequences with a chemical profile s...
Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening [0.03%]
基于机器学习的共识虚拟筛选鉴定人源系末端脱氧核苷酸转移酶N端结构域(FEN1)抑制剂
Amit Laxmikant Deshmukh,Sharat Chandra,Deependra Kumar Singh et al.
Amit Laxmikant Deshmukh et al.
Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomi...
iMulti-HumPhos: a multi-label classifier for identifying human phosphorylated proteins using multiple kernel learning based support vector machines [0.03%]
基于支持向量机的多核学习方法的人类磷酸化蛋白多标签分类器:iMulti-HumPhos
Md Al Mehedi Hasan,Shamim Ahmad,Md Khademul Islam Molla
Md Al Mehedi Hasan
Protein phosphorylation plays a potential role in regulating protein conformation and functions. As a result, identifying an uncharacterized protein sequence as a phosphorylated protein is a very meaningful problem and an urgent issue for b...
Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death [0.03%]
供氢硫化物的胶束可保护心肌细胞免于缺血性死亡
T Takatani-Nakase,M Katayama,C Matsui et al.
T Takatani-Nakase et al.
Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H2S donor mic...
An integrative machine learning strategy for improved prediction of essential genes in Escherichia coli metabolism using flux-coupled features [0.03%]
基于流量耦合特征提高大肠杆菌代谢必需基因预测的集成机器学习策略
Sutanu Nandi,Abhishek Subramanian,Ram Rup Sarkar
Sutanu Nandi
Prediction of essential genes helps to identify a minimal set of genes that are absolutely required for the appropriate functioning and survival of a cell. The available machine learning techniques for essential gene prediction have inheren...
Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells [0.03%]
四环素可控人工microRNA-HOTAIR+EZH2抑制膀胱癌细胞进展
Yincong Chen,Haibiao Xie,Yifan Zou et al.
Yincong Chen et al.
Previous studies have suggested that EZH2 is up-regulated in bladder cancer tissues and identified it as a biomarker for poor prognosis. However, the biological functions of EZH2 in bladder cancer cells remain unknown. In this research, we ...
Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis [0.03%]
代谢组学结合模式识别和生物信息学方法用于肝纤维化药效生物标志物的开发
Junwei Fang,Liping Wang,Yang Wang et al.
Junwei Fang et al.
The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biological activities. As the modulation of metabolites may reflect the biological changes occurring ...
Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum [0.03%]
使用胚胎体模型用人多能干细胞衍生收缩心肌细胞的转录组动力学研究（含胎牛血清）
Kwang Bo Jung,Ye Seul Son,Hana Lee et al.
Kwang Bo Jung et al.
Cardiomyocyte (CM) differentiation techniques for generating adult-like mature CMs remain imperfect, and the plausible underlying mechanisms remain unclear; however, there are a number of current protocols available. Here, to explore the me...
Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design [0.03%]
小分子结合诱导的c-MYC四链体DNA构象预组化及其在结构特异性药物设计中的应用
S Harikrishna,Saikiran Kotaru,P I Pradeepkumar
S Harikrishna
Stabilization of a G-quadruplex (G4) DNA structure in the proto-oncogene c-MYC using small molecule ligands has emerged as an attractive strategy for the development of anticancer therapeutics. To understand the subtle structural changes in...
Interaction and inhibitory influence of the azo dye carmoisine on lysozyme amyloid fibrillogenesis [0.03%]
偶氮染料卡墨森与溶菌酶淀粉样纤维形成的相互作用及抑制效应
Anirban Basu,Gopinatha Suresh Kumar
Anirban Basu
The binding of the common food colorant carmoisine and its inhibitory effect on amyloid fibrillation in lysozyme have been investigated. Since humans are increasingly exposed to various food colorants like carmoisine, such studies are highl...