Effect of a Ru(II) polypyridyl complex [Ru(bpy)2(mdpz)]2+ on the stabilization of the RNA triplex poly(U)·poly(A)*poly(U) [0.03%]
[Ru(bpy)₂(mdpz)]²⁺对RNA三链体poly(U)·poly(A)*poly(U)稳定作用的影响研究
Xiaojun He,Jia Li,Hong Zhang et al.
Xiaojun He et al.
There is renewed interest in investigating triplex nucleic acids because triplexes may be implicated in a range of cellular functions. However, the stabilization of triplex nucleic acids is essential to achieve their biological functions. I...
Modeling metabolism and stage-specific growth of Plasmodium falciparum HB3 during the intraerythrocytic developmental cycle [0.03%]
间皮细胞发育周期中模拟HB3恶性疟原虫的代谢及特定生长阶段
Xin Fang,Jaques Reifman,Anders Wallqvist
Xin Fang
The human malaria parasite Plasmodium falciparum goes through a complex life cycle, including a roughly 48-hour-long intraerythrocytic developmental cycle (IDC) in human red blood cells. A better understanding of the metabolic processes req...
Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection [0.03%]
基于网络药理学的中医药治疗上呼吸道感染机制研究
Xinzhuang Zhang,Jiangyong Gu,Liang Cao et al.
Xinzhuang Zhang et al.
Traditional Chinese medicine (TCM) is a multi-component and multi-target agent and could treat complex diseases in a holistic way, especially infection diseases. However, the underlying pharmacology remains unclear. Fortunately, network pha...
Comparative study of Plasmodium falciparum erythrocyte membrane protein 1-DBLα domain variants with respect to antigenic variations and docking interaction analysis with glycosaminoglycans [0.03%]
抗原变异和与糖胺聚糖对接相互作用分析的Plasmodium falciparum红细胞膜蛋白1-DBLα结构域变异的比较研究
Megha R Agrawal,Aarti D Ozarkar,Shipra Gupta et al.
Megha R Agrawal et al.
The variant surface antigen PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) encoded by the polymorphic multi-copy var gene family plays an important role in parasite biology and the host-parasite interactions. Sequestration an...
Comparative Study
Molecular bioSystems. 2014 Jul 29;10(9):2466-79. DOI:10.1039/c4mb00274a 2014
KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model [0.03%]
基于基因和基因组的知识库路径分析模型方法KEGG-PATH
Junli Du,Zhifa Yuan,Ziwei Ma et al.
Junli Du et al.
The dynamic impact approach (DIA) represents an alternative to overrepresentation analysis (ORA) for functional analysis of time-course experiments or those involving multiple treatments. The DIA can be used to estimate the biological impac...
Viral proteins that bridge unconnected proteins and components in the human PPI network [0.03%]
能连接人类PPI网络中不相连蛋白和组件的病毒蛋白
H R Rachita,H A Nagarajaram
H R Rachita
Viruses, despite having small genomes and few proteins, make an array of interactions with host proteins as they solely depend on host machinery for their replication and reproduction. Hence, analysis of the Human-Virus Protein-Protein Inte...
The role of flexibility and optimality in the prediction of intracellular fluxes of microbial central carbon metabolism [0.03%]
可塑性和最优性在预测微生物胞内核心代谢途径通量中的作用
Fatih Tarlak,Hasan Sadıkoğlu,Tunahan Çakır
Fatih Tarlak
Prediction of intracellular metabolic fluxes based on optimal biomass assumption is a well-known computational approach. While there has been a significant emphasis on the optimality, cellular flexibility, the co-occurrence of suboptimal fl...
NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats [0.03%]
基于核磁共振代谢组学的慢性蓖麻毒素毒性的研究
Pingping Guo,Junsong Wang,Ge Dong et al.
Pingping Guo et al.
Ricin, a large, water soluble toxic glycoprotein, is distributed majorly in the kernels of castor beans (the seeds of Ricinus communis L.) and has been used in traditional Chinese medicine (TCM) or other folk remedies throughout the world. ...
Robust coordination of cardiac functions from gene co-expression reveals a versatile combinatorial transcriptional control [0.03%]
来自基因共表达的心脏功能的稳健协调揭示了多种组合转录控制
Catherine Cerutti,Giampiero Bricca,Sophie Rome et al.
Catherine Cerutti et al.
The necessary overall coordination of cardiac cellular functions is little known at the mRNA level. Focusing on energy production and cardiac contraction, we analyzed microarray data from heart tissue obtained in groups of mice and rats in ...
Identifying ion channel genes related to cardiomyopathy using a novel decision forest strategy [0.03%]
利用新型决策森林策略识别与心肌病相关的离子通道基因
Jie Zhang,Guanghua Wang,Jian Feng et al.
Jie Zhang et al.
Ion channels play many crucial functions in life. Their dysfunction may lead to a number of diseases, such as arrhythmia and beta cell dysfunction. In this study, we firstly selected the ion channel gene expression profiles using a dimensio...