Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene [0.03%]
人GRIN1基因启动子点突变导致的多链G-四链体到单链的结构转换
Swati Chaudhary,Mahima Kaushik,Ritushree Kukreti et al.
Swati Chaudhary et al.
A huge number of G-rich sequences forming quadruplexes are found in the human genome, especially in telomeric regions, UTRs, and the promoter regions of a number of genes. One such gene is GRIN1 encoding the NR1 subunit of the N-methyl-d-as...
An enhanced hTERT promoter-driven CRISPR/Cas9 system selectively inhibits the progression of bladder cancer cells [0.03%]
一个增强的hTERT启动子驱动的CRISPR/Cas9系统选择性抑制膀胱癌细胞的进展
Xinbo Huang,Chengle Zhuang,Changshui Zhuang et al.
Xinbo Huang et al.
The current therapies for treating tumors are lacking in efficacy and specificity. Synthetic biology principles may bring some new possible methods for curing cancer. Here we present a synthetic logic circuit based on the CRISPR/Cas9 system...
Identification of perturbed signaling pathways from gene expression data using information divergence [0.03%]
基于信息散度的基因表达数据分析扰动信号通路的方法
Xinying Hu,Hang Wei,Haoran Zheng
Xinying Hu
Abnormal regulation of signaling pathways is the key causative factor in several diseases. Although many methods have been proposed to identify significantly differential pathways between two conditions via microarray gene expression datase...
LPI-ETSLP: lncRNA-protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction [0.03%]
基于特征值转换的半监督链预测的LPI-ETSLP算法：用于预测长链非编码核糖核酸-蛋白质相互作用
Huan Hu,Chunyu Zhu,Haixin Ai et al.
Huan Hu et al.
RNA-protein interactions are essential for understanding many important cellular processes. In particular, lncRNA-protein interactions play important roles in post-transcriptional gene regulation, such as splicing, translation, signaling an...
pLoc-mPlant: predict subcellular localization of multi-location plant proteins by incorporating the optimal GO information into general PseAAC [0.03%]
基于最佳GO信息的多定位植物蛋白亚细胞定位预测方法pLoc-mPlant
Xiang Cheng,Xuan Xiao,Kuo-Chen Chou
Xiang Cheng
One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. To realize this, it is indispensable to develop an automated metho...
Identifying the common genetic networks of ADR (adverse drug reaction) clusters and developing an ADR classification model [0.03%]
识别ADR(药品不良反应)集群的共同遗传网络及开发一种ADR分类模型
Youhyeon Hwang,Min Oh,Giup Jang et al.
Youhyeon Hwang et al.
Adverse drug reactions (ADRs) are one of the major concerns threatening public health and have resulted in failures in drug development. Thus, predicting ADRs and discovering the mechanisms underlying ADRs have become important tasks in pha...
Functional roles of intrinsic disorder in CRISPR-associated protein Cas9 [0.03%]
CRISPR相关蛋白Cas9中固有无序区域的功能作用
Zhihua Du,Vladimir N Uversky
Zhihua Du
Protein intrinsic disorder is an important characteristic commonly detected in multifunctional or RNA- and DNA-binding proteins. Due to their high conformational flexibility and solvent accessibility, intrinsically disordered proteins (IDPs...
Modeling of alcohol oxidase enzyme of Candida boidinii and in silico analysis of competitive binding of proton ionophores and FAD with enzyme [0.03%]
应用于酿酒酵母酒醇氧化酶的质子离子载体及FAD竞争结合的分子对接模拟研究
Mohammad Wahab Khan,Ayaluru Murali
Mohammad Wahab Khan
Alcohol oxidase (AOX) is an important flavin adenine dinucleotide (FAD) dependent oxidoreductase, which is responsible for converting methanol into formaldehyde and hydrogen peroxide for the growth of methylotrophic yeast Candida boidinii. ...
Identification of microRNA precursors using reduced and hybrid features [0.03%]
基于降维和混合特征的微小核糖核酸前体识别方法
Asad Khan,Sajid Shah,Fazli Wahid et al.
Asad Khan et al.
MicroRNAs (also called miRNAs) are a group of short non-coding RNA molecules. They play a vital role in the gene expression of transcriptional and post-transcriptional processes. However, abnormality of their expression has been observed in...
C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment? [0.03%]
1型糖尿病的C-肽替代治疗：我们在沮丧之谷吗？
C W Pinger,K E Entwistle,T M Bell et al.
C W Pinger et al.
Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, ...