Anamaria C Herta,Francesca Lolicato,Johan E J Smitz
Anamaria C Herta
The currently available assisted reproduction techniques for fertility preservation (i.e. in vitro maturation (IVM) and in vitro fertilization) are insufficient as stand-alone procedures as only few reproductive cells can be conserved with ...
Darren K Griffin,Cagri Ogur
Darren K Griffin
Designed to minimize chances of genetically abnormal embryos, preimplantation genetic diagnosis (PGD) involves in vitro fertilization (IVF), embryo biopsy, diagnosis and selective embryo transfer. Preimplantation genetic testing for aneuplo...
CFTR is required for the migration of primordial germ cells during zebrafish early embryogenesis [0.03%]
囊泡转运调控子CTFR在斑马鱼原始生殖细胞早期胚胎迁移中的作用不可或缺
Huijuan Liao,Yan Chen,Yulong Li et al.
Huijuan Liao et al.
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene affect fertility in both sexes. However, the involvement of CFTR in regulating germ cell development remains largely unknown. Here, we used zebrafish model to ...
Activated-farnesoid X receptor (FXR) expressed in human sperm alters its fertilising ability [0.03%]
活化型法尼醇X受体（FXR）在人精子中的表达改变了其受精能力
R Malivindi,M Santoro,D De Rose et al.
R Malivindi et al.
The farnesoid X receptor alpha (FXR) is a bile acid sensor activated by binding to endogenous bile acids including chenodeoxycholic acid (CDCA). Although, FXR is expressed in male reproductive tissue, the relevance of the receptor on reprod...
Genomic integrity in the male germ line: evidence in support of the disposable soma hypothesis [0.03%]
男性生殖细胞基因组的完整性：支持"可抛弃体细胞理论"的证据
Miguel J Xavier,Lisa A Mitchell,Kristen E McEwan et al.
Miguel J Xavier et al.
The Big Blue λSelect-cII selection system has been employed along with whole-exome sequencing to examine the susceptibility of the male germ line to mutation in two challenging situations (i) exposure to a chemotherapeutic regime including...
Expression of atresia biomarkers in granulosa cells after ovarian stimulation in heifers [0.03%]
卵巢刺激后肉牛颗粒细胞闭锁标志物的表达
David A Landry,Lia Rossi-Perazza,Simon Lafontaine et al.
David A Landry et al.
The use of younger gamete donors in dairy cattle genetic selection programs significantly accelerates genetic gains by decreasing the interval between generations. Ovarian stimulation (OS) and the practice of follicle-stimulating hormone (F...
Lena Walenta,Nina Schmid,J Ullrich Schwarzer et al.
Lena Walenta et al.
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing ...
Alan H Handyside
Alan H Handyside
The first pregnancies and live births following in vitro fertilisation (IVF) and preimplantation genetic testing (PGT), formerly known as preimplantation genetic diagnosis, were reported in 1990, almost 30 years ago, in several couples at r...
SPEN protein expression and interactions with chromatin in mouse testicular cells [0.03%]
小鼠睾丸细胞中SPEN蛋白的表达及其与染色体的作用关系研究
Joanna Korfanty,Tomasz Stokowy,Marek Chadalski et al.
Joanna Korfanty et al.
SPEN (spen family transcription repressor) is a nucleic acid-binding protein putatively involved in repression of gene expression. We hypothesized that SPEN could be involved in general downregulation of the transcription during the heat sh...
Casey C Nestor,Michelle N Bedenbaugh,Stanley M Hileman et al.
Casey C Nestor et al.
Early work in ewes provided a wealth of information on the physiological regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal and external inputs. Identification of the neural systems involved, however, was li...