Primordial germ cells do not migrate along nerve fibres in marmoset monkey and mouse embryos [0.03%]
绒猴和小鼠胚胎原始生殖细胞不沿神经纤维迁移
E Wolff,M M Suplicki,R Behr
E Wolff
Primordial germ cells (PGCs) are the embryonic precursors of spermatozoa and eggs. In mammals, PGCs arise early in embryonic development and migrate from their tissue of specification over a significant distance to reach their destinations,...
D Ioannou,J Fortun,H G Tempest
D Ioannou
Infertility is relatively common affecting approximately 1-in-6 couples. Although the genetic basis of infertility is increasingly being uncovered, the contribution of male infertility often remains unexplained. The leading cause of pregnan...
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis [0.03%]
异常的PTEN表达作为对孕酮的反应减少子宫内膜异位病灶成纤维细胞凋亡
JongYeob Choi,MinWha Jo,EunYoung Lee et al.
JongYeob Choi et al.
In some human cancer cells, PTEN (phosphatase and tensin homolog deleted on chromosome 10) is known to regulate autophagy induction positively through the inhibition of PI3K/AKT pathway, leading to the activation of mTOR, a major negative r...
Kevin N Keane,Vinicius F Cruzat,Emily K Calton et al.
Kevin N Keane et al.
Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory dise...
Inhibition of TMEM16A impedes embryo implantation and decidualization in mice [0.03%]
TMEM16A抑制作用阻碍小鼠胚胎着床和蜕膜化
Qianrong Qi,Yifan Yang,Kailin Wu et al.
Qianrong Qi et al.
Recent studies revealed that TMEM16A is involved in several reproductive processes, including ovarian estrogen secretion and ovulation, sperm motility and acrosome reaction, fertilization and myometrium contraction. However, little is known...
Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion [0.03%]
删除Eqtn基因可降低小鼠雄性生育能力及精子与卵子的粘附力
Chizuru Ito,Kenji Yamatoya,Keiichi Yoshida et al.
Chizuru Ito et al.
A number of sperm proteins are involved in the processes from gamete adhesion to fusion, but the underlying mechanism is still unclear. Here, we established a mouse mutant, the EQUATORIN-knockout (EQTN-KO, Eqtn - / - ) mouse model and found...
Comparative Study
Reproduction (Cambridge, England). 2018 Dec;156(6):579-590. DOI:10.1530/REP-18-0394 2018
Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cells [0.03%]
雌激素调节的miRNA-27b被双酚A改变
Beverly G Reed,Samir N Babayev,Lucy X Chen et al.
Beverly G Reed et al.
MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disrupto...
Elevation of autophagy rescues spermatogenesis by inhibiting apoptosis of mouse spermatocytes [0.03%]
自噬作用的提升通过抑制小鼠精母细胞凋亡来拯救生精作用
Jun Yin,Bing Ni,Yi-Dong Yang et al.
Jun Yin et al.
Autophagy and apoptosis are interlocked in an extensive crosstalk. Our previous study demonstrated that hypotonic hypoxia-induced marked apoptosis of a spermatocyte-derived cell line (GC-2). However, whether hypoxia-induced apoptosis is med...
Dynamics of fatty acid regulatory genes during ovarian development in Penaeus monodon [0.03%]
凡纳滨螺卵巢发育过程中脂肪酸调控基因的表达动态研究
Pacharawan Deenarn,Punsa Tobwor,Rungnapa Leelatanawit et al.
Pacharawan Deenarn et al.
The delay in ovarian maturation in farmed black tiger shrimp Penaeus monodon has resulted in the widespread practice of feeding broodstock with the polychaete Perinereis nuntia and their unilateral eyestalk ablation. Although this practice ...
Apoptotic germ cells regulate Sertoli cell lipid storage and fatty acid oxidation [0.03%]
凋亡的生精细胞调节支持细胞的脂质储存和脂肪酸氧化
Mariana Regueira,Agostina Gorga,Gustavo Marcelo Rindone et al.
Mariana Regueira et al.
The presence of lipid droplets (LD) and the utilization of fatty acids (FA) as a source of energy are Sertoli cell (SC) putative characteristics. It is well known that SCs can phagocyte and degrade apoptotic germ cells (AGC) resulting in in...