Thrombospondin-1 at the crossroads of corpus luteum fate decisions [0.03%]
thrombospondin-1在卵泡命运决定的交叉路口
Svetlana Farberov,Raghavendra Basavaraja,Rina Meidan
Svetlana Farberov
The multimodular matricellular protein thrombospondin-1 (THBS1) was among the first identified endogenous antiangiogenic molecules. Recent studies have shown THBS1-mediated suppression of angiogenesis and other critical activities for corpu...
WOMEN IN REPRODUCTIVE SCIENCE: My WOMBan's life: understanding human endometrial function [0.03%]
生殖医学中的女性力量：我的她生涯：了解人类子宫内膜功能
Lois A Salamonsen
Lois A Salamonsen
The focus of my life in science has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for the establishment of pre...
Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function [0.03%]
雌二醇通过MALAT1/miR200s海绵作用促进子宫内膜异位症上皮间质转化
Yu Du,Zhibing Zhang,Wenqian Xiong et al.
Yu Du et al.
Endometriosis is an estrogen-dependent benign gynecological disease that shares some common features of malignancy. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism of endometriosis. MALAT1 is widely known as ...
Tomer Avidor-Reiss,Emily L Fishman
Tomer Avidor-Reiss
Cells that divide during embryo development require precisely two centrioles during interphase and four centrioles during mitosis. This precise number is maintained by allowing each centriole to nucleate only one centriole per cell cycle (i...
Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos [0.03%]
Scriptaid抑制RNA合成可提高体细胞克隆胚胎基因重编程效率
Vitor Braga Rissi,Werner Giehl Glanzner,Mariana Priotto de Macedo et al.
Vitor Braga Rissi et al.
Insufficient epigenetic reprogramming is incompatible with normal development of embryos produced by somatic cell nuclear transfer (SCNT), but treatment with histone deacetylases inhibitors (HDACi) enhances development of SCNT embryos. Howe...
Different pre-implantation phenotypes of bovine blastocysts produced in vitro [0.03%]
不同体外培养牛胚的囊胚前表型差异性研究
Isabelle Hue,Isabelle Dufort,Anaïs Vitorino Carvalho et al.
Isabelle Hue et al.
Embryo transfer in cattle is performed with blastocysts produced in vivo or in vitro using defined media. However, outdated systems such as those that use serum and co-culture remain of interest for research purposes. Here, we investigated ...
Slo3 K+ channel blocker clofilium extends bull and mouse sperm-fertilizing competence [0.03%]
Slo3钾通道阻断剂克利利厄姆延长公牛和小鼠精子的受精能力
Roland Abi Nahed,Guillaume Martinez,Jean Pascal Hograindleur et al.
Roland Abi Nahed et al.
For artificial insemination (AI) to be successful, it is essential that sperm delivery be perfectly timed relative to ovulation, as sperm lifespan is limited due to oxidative metabolism induced by capacitation. Extending the window of sperm...
Ruizhi Deng,Chengquan Han,Lu Zhao et al.
Ruizhi Deng et al.
Endogenous retroviruses (ERVs), which are abundant in mammalian genomes, can modulate the expression of nearby genes, and their expression is dynamic and stage-specific during early embryonic development in mice and humans. However, the fun...
Decidual expression and regulation of fatty acid desaturase 3 during mouse decidualization [0.03%]
小鼠蜕膜化过程中脂肪酸去饱和酶3的表达与调控
Shuai Lin,Yu-Yuan Zhu,Wei Hu et al.
Shuai Lin et al.
Decidualization is required for the successful establishment of pregnancy in rodents and primates. Fatty acid desaturase 3 (Fads3) belongs to the fatty acid desaturase family, which is a crucial enzyme for highly unsaturated fatty acid bios...
Versican V1 in human endometrial epithelial cells promotes BeWo spheroid adhesion in vitro [0.03%]
人类子宫内膜上皮细胞中的透明质酸合酶促进体内BeWo类器官的粘附
Yumiko Miyazaki,Akihito Horie,Hirohiko Tani et al.
Yumiko Miyazaki et al.
The endometrium extracellular matrix (ECM) is essential for embryo implantation. Versican, a large chondroitin sulfate proteoglycan that binds hyaluronan and forms large ECM aggregates, can influence fundamental physiological phenomena, suc...