Changes to the reproductive microbiome of the brood pouch during male pregnancy in seahorses (Hippocampus abdominalis) [0.03%]
雄性怀孕期间海马(Hippocampus abdominalis)育儿囊的生殖微生物组变化
Jenny Wang,Zoe Skalkos,Catherine Grueber et al.
Jenny Wang et al.
Seahorses demonstrate an unusual reproductive strategy in which males incubate embryos inside a complex "brood pouch" until parturition, analogous to mammalian viviparity. In many species, a "normal" reproductive microbiome ensures successf...
Elevated expression and reduced phosphorylation of uterine RIG-I protein in pathogenic preterm labor in mice [0.03%]
小鼠病理性早产中子宫RIG-I蛋白的表达升高及磷酸化降低
Ayushi Vaidhya,G Ravi Prakash,Dhaval J Kamothi et al.
Ayushi Vaidhya et al.
Unlike TLRs, the regulation of RIG-I-like receptors (RLRs) in preterm labor (PTL) is not well understood. It is unclear if the RLR pathway is activated in uterine tissue during preterm labor and whether this activation is specific to pathog...
A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice [0.03%]
共生微生物的缺乏影响小鼠跨代的雄性生殖系统
Natalie A Trigg,Simon K Zhou,Jordan C Harris et al.
Natalie A Trigg et al.
The microbiome encompasses the array of microorganisms inhabiting various niches in the body and is necessary for numerous physiological processes, including normal metabolism and a functioning immune system. Not only does the absence of a ...
Stephen Ameho,Michael Klustein
Stephen Ameho
Inflammation has key biological roles in the battle against pathogens, and additional key processes in development and tissue homeostasis. However, when inflammation becomes chronic it can become a serious medical concern. Chronic inflammat...
Potent and sustained enhancement of human sperm motility using novel cyclic AMP up-regulators [0.03%]
新型环AMP增效剂可强力提升人类精子运动能力
Natalia Oscoz Susino,Guillermina M Luque,Florencia Minotti et al.
Natalia Oscoz Susino et al.
Cyclic adenosine monophosphate (cAMP) plays a central role in sperm physiology. Various cAMP up-regulators, both cAMP analogs and phosphodiesterase (PDE) inhibitors, have been used in handling human sperm in vitro, though conflicting result...
Drosophila AK-3, a homologue of human CKMT1B, is essential for spermiogenesis [0.03%]
果蝇AK-3是人CKMT1B同源物，在精子变形过程中发挥重要作用
Meng-Yan Chen,Qian Zhao,Ying-Ying Wang et al.
Meng-Yan Chen et al.
Spermatogenesis is a conserved process across animals, involving in proliferation and maintenance of germ stem cells, haploid spermatid production via meiosis, generation of mature sperm with unique shapes. Our previous studies revealed tha...
Uterine stromal but not epithelial PTGS2 is critical for murine pregnancy success [0.03%]
子宫间质而非上皮PTGS2在小鼠成功怀孕中起关键作用
Noura Massri,Ripla Arora
Noura Massri
Use of non-steroidal anti-inflammatory drugs that target prostaglandin synthase (PTGS) enzymes have been implicated in miscarriage. Further, PTGS2-derived prostaglandins are reduced in the endometrium of patients with a history of implantat...
IGF2BP1 stabilizes Akt2 mRNA to promote glucose metabolism and maintain spermatogonial proliferation [0.03%]
IGF2BP1通过稳定Akt2 mRNA来促进葡萄糖代谢和维持精原细胞增殖
Yanan Liu,Yuanyuan Chen,Jiahui Fan et al.
Yanan Liu et al.
Insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), as a newly identified N6-methyladenosine (m6A) methylation reader, plays a key role in mRNA stability, alternative splicing, and translation. However, the function of IGF2BP1 an...
CD40 Ligand and CD40: Expression, Regulation, and Function at the Maternal-Conceptus Interface in Pigs [0.03%]
猪母体-胚囊界面CD40和CD40配体的表达、调控及功能
Inkyu Yoo,Soohyung Lee,Yugyeong Cheon et al.
Inkyu Yoo et al.
To successfully establish and maintain pregnancy in pigs, a variety of factors must work together at the maternal-conceptus interface to form an immune environment appropriate for both the mother and the conceptus. Our transcriptomics study...
Increased plugging latency in cycling epiERα-/- (Esr1f/-Wnt7aCre/+) mice [0.03%]
在周期性表观ERα基因敲除小鼠中插管延迟增加
Jonathan Matthew Hancock,Taylor Elijah Martin,Zidao Wang et al.
Jonathan Matthew Hancock et al.
Wnt7a-Cre is a commonly used for generating uterine epithelial conditional knockout mice, such as epiERα-/- (Esr1f/-Wnt7aCre/+) and epiPR-/- (Pgrf/-Wnt7aCre/+). We noticed that epiERα-/- females, but not epiPR-/- females, have prolonged p...