Prepubertal PTU treatment in rat increases Sertoli cell number and sperm production [0.03%]
妊娠期阻断甲状腺素生成可增加大鼠支持细胞数量和精子产生量
André F A Figueiredo,Natália Teixeira Wnuk,Amanda O Tavares et al.
André F A Figueiredo et al.
The number of Sertoli cells (SCs) ultimately determines the upper limit of sperm production in the testis. Previous studies have shown that thyroid hormones (TH) receptors are abundantly expressed in developing SCs; therefore, it was highly...
Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells [0.03%]
维生素D对子宫和外周NK细胞反应的转录组分析
J A Tamblyn,L E Jeffery,R Susarla et al.
J A Tamblyn et al.
Vitamin D deficiency is prevalent in pregnant women and is associated with adverse pregnancy outcomes, in particular disorders of malplacentation. The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a potent regulator o...
Comparative Study
Reproduction (Cambridge, England). 2019 Aug;158(2):211-221. DOI:10.1530/REP-18-0509 2019
Alpha-ketoglutarate affects murine embryo development through metabolic and epigenetic modulations [0.03%]
α-酮戊二酸通过代谢和表观遗传调节影响小鼠胚胎发育
Zhenzhen Zhang,Changjiu He,Lu Zhang et al.
Zhenzhen Zhang et al.
α-Ketoglutarate (α-KG) is an intermediary metabolite in the tricarboxylic acid (TCA) cycle and functions to inhibit ATPase and maintain the pluripotency of embryonic stem cells (ESCs); however, little is known regarding the effects of α-...
The sperm-associated antigen 6 interactome and its role in spermatogenesis [0.03%]
精子相关抗原6的相互作用网络及其在精子发生中的作用
Yunhao Liu,Ling Zhang,Wei Li et al.
Yunhao Liu et al.
Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has fun...
Immune molecules in the female reproductive path and sperm: relevance to mate choice [0.03%]
生殖道免疫分子与精子：择偶的相关性研究进展
Irene Mytilinaiou,Kiki Sarganaki,Eirini Sachouli et al.
Irene Mytilinaiou et al.
Mate choice has been postulated to be MHC-dependent, ensuring the maintenance of polymorphism for species survival. At the molecular level, MHC polymorphism is represented by class-I (MHCI), class-II (MHCII) antigens and their T cell recept...
What makes a fertile sperm? Unique molecular attributes of stallion fertility [0.03%]
公马精子富有生育力的分子特征是什么？
Róisín A Griffin,Mark Baker,Robert John Aitken et al.
Róisín A Griffin et al.
Stallions experience lower per-cycle conception rates compared to other livestock species, largely because they are selected for breeding based on athletic prowess and not reproductive fitness. Mares are seasonal breeders, and pregnancies c...
Tissue-specific knockout of E-cadherin (Cdh1) in developing mouse gonads causes germ cells loss [0.03%]
发育中的小鼠生殖腺中E-钙粘着蛋白(Cdh1)的组织特异性敲除导致了生殖细胞丢失
Rafal P Piprek,Michal Kolasa,Dagmara Podkowa et al.
Rafal P Piprek et al.
The normal course of gonad development is critical for the sexual development and reproductive capacity of the individual. During development, an incipient bipotential gonad which consists of unorganized aggregate of cells, must differentia...
Marie-Madeleine Dolmans,Christiani A Amorim
Marie-Madeleine Dolmans
Increasing numbers of patients are now surviving previously fatal malignant diseases, so for women of childbearing age, fertility concerns are paramount once they are cured. However, the treatments themselves, namely chemo- and radiotherapy...
Vaspin in the pig ovarian follicles: expression and regulation by different hormones [0.03%]
猪卵巢卵泡中Vaspin的表达及其不同激素调节作用
Patrycja Kurowska,Ewa Mlyczyńska,Alix Barbe et al.
Patrycja Kurowska et al.
Vaspin, also known as visceral adipose tissue-derived serine protease inhibitor, is a member of the serine protease inhibitor family. Its expression is associated with obesity, insulin resistance and type 2 diabetes, and elevated concentrat...
Sperm and seminal plasma RNAs: what roles do they play beyond fertilization? [0.03%]
精子和精浆中的RNA：受精后的功能是什么？
Meritxell Jodar
Meritxell Jodar
The paternal contribution to the new individual is not just limited to half the diploid genome. Recent findings have shown that sperm delivers to the oocyte several components, including a complex population of RNAs, which may influence ear...