Placental interleukin 1β signaling in canine pregnancy: differential effects during and after decidualization in vitro [0.03%]
犬妊娠期间胎盘白细胞介素1β信号：体外蜕膜化过程中和之后的差异效应
Miguel Tavares Pereira,Selim Aslan,Rita Payan-Carreira et al.
Miguel Tavares Pereira et al.
Although implantation and parturition are associated with pro-inflammatory signals, inflammatory responses in the mature placenta frequently lead to pregnancy loss. Indeed, uterine inflammatory/infectious diseases are major causes of infert...
Daniel A Dumesic,Vasantha Padmanabhan,David H Abbott
Daniel A Dumesic
Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged women characterized by hyperandrogenism, oligo-anovulation and insulin resistance in combination with preferential abdominal fat accumulation. As an ancestral ...
Nicotinic acid protects germinal vesicle oocyte meiosis against toxicity of benzo(a)pyrene in mice and humans [0.03%]
烟酸保护小鼠和人类的GV卵母细胞减数分裂免受BaP毒性损伤
Min Gao,Yanling Qiu,Dungao Li et al.
Min Gao et al.
Benzo(a)pyrene (BaP) was detected in human follicular fluid at concentrations of approximately 5 nM in smokers and 7 nM in cases of assisted reproductive failure. However, whether low concentration of BaP affects germinal vesicle (GV) oocyt...
Irisin decreases follicle development in cattle and inhibits theca cell steroidogenesis through focal adhesion kinase signaling [0.03%]
Irisin通过聚集粘附激酶信号降低牛的卵泡发育并抑制类固醇生成作用
Mathilde Daudon,Christelle Ramé,Marcos H Barreta et al.
Mathilde Daudon et al.
At the onset of lactation, dairy cattle are anestrous owing mainly to a state of negative energy balance. Adipose tissue is mobilized to meet the energy demands of milk production, and this alters the secretion of adipose-derived hormones, ...
The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinaemia [0.03%]
吻肽类类似物C6可逆转高泌乳素血症小鼠模型中的生殖功能障碍
Chloe Beaudou,Louise Sionneau,Didier Lomet et al.
Chloe Beaudou et al.
Hyperprolactinaemia (HPRL), characterized by elevated prolactin levels, disrupts the hypothalamic-pituitary-gonadal axis, leading to reproductive dysfunctions such as menstrual irregularities, anovulation, and infertility. Current treatment...
Progesterone supplementation after postovulatory mifepristone reduce changes in human endometrial gene expression [0.03%]
产后使用黄体酮补充米非司酮减少人类子宫内膜基因表达的变化
Alejandro Tapia-Pizarro,Nicolás Santander,Abril Salinas et al.
Alejandro Tapia-Pizarro et al.
Mifepristone (RU486) antagonizes progesterone signaling in human endometrium interfering in the secretory phenotype after estradiol priming. The objective of the present study was to determine effect in the endometrial transcript profile of...
Decoding bull fertility in vitro: A proteomics exploration from sperm to blastocyst [0.03%]
体外解码公牛受精能力：从精子到胚泡的蛋白质组探索
Andrea Fernández Montoro,Emin Araftpoor,Tine De Coster et al.
Andrea Fernández Montoro et al.
Male fertility plays a pivotal role in the success rates of in vitro embryo production. While livestock breeding programs rigorously select bulls according to their predicted field fertility, specific traits like polyspermy rates are not ro...
Beneficial effects of melatonin on canine oocyte nuclear maturation via reduction of oxidative stress [0.03%]
褪黑激素通过减少氧化应激对犬卵母细胞核成熟的影响研究
Fataneh Ghafari,Mazdak Salavati,Richard J Piercy et al.
Fataneh Ghafari et al.
Unlike other domesticated animals, in vitro maturation of canine oocytes results in poor nuclear maturation to the metaphase II stage and high oocyte degeneration. The high fat content of canine oocytes is the likely cause; it predisposes t...
Defining core signaling pathways for supporting in vitro maintenance of pig extraembryonic endoderm (XEN) cells [0.03%]
定义支持体外维持猪额外胚胎内胚层(XEN)细胞的核心信号通路
Jinsol Jeong,Dong-Kyung Lee,Kwang-Hwan Choi et al.
Jinsol Jeong et al.
Extraembryonic endoderm (XEN) cells can be derived from blastocyst primitive endoderm (PrE), becoming a useful tool for studying mammalian development, including early lineage segregation and embryo patterning. Establishment of stem cells r...
Mammalian heat shock protein A4 family ortholog Hsc70Cb is required for two phases of spermatogenesis in D. melanogaster [0.03%]
哺乳动物热休克蛋白A4家族同源物Hsc70Cb对D. melanogaster的两个精子发生阶段是必需的
Brendan J Houston,Joseph Nguyen,Richard Burke et al.
Brendan J Houston et al.
Heat shock proteins play essential roles as molecular chaperones, enacting protein folding and preventing protein aggregation. In a previous study, a homozygous non-synonymous genetic variant that was predicted to be damaging was detected i...