Manujaya W Jayamanna Mohottige,Emma Peel,Angéla Juhász et al.
Manujaya W Jayamanna Mohottige et al.
Tasmanian devils (Sarcophilus harrisii), like all marsupials, give birth to altricial young. Here we employ proteomic analysis to identify components of devil pouch secretions that may contribute to offspring survival and development. Prote...
Single-cell Transcriptomics Reveals Cytotrophoblast Subtypes and Senescence in Recurrent Spontaneous Abortion [0.03%]
单细胞转录组揭示反复自然流产的合体滋养物亚型及衰老现象
Si-Man Chen,Meng-Ying Li,Yi-Xing Yang et al.
Si-Man Chen et al.
Recurrent spontaneous abortion (RSA), defined as the loss of two or more pregnancies before 20 weeks of gestation, remains a challenging clinical problem with largely unknown pathogenesis. In this study, we performed single-cell RNA sequenc...
Reproductive Effects of Combined PCOS Model and High-Fat Diet: Tracing Inheritance [0.03%]
多囊卵巢综合征模型与高脂饮食联合作用的生殖效应及遗传追溯
Pedro Javier Torres,Rocío Maldonado,Pablo Pérez et al.
Pedro Javier Torres et al.
The objective of this study was to evaluate in mice, the effects of combining a prenatal androgenization-induced polycystic ovary syndrome model with a high-fat diet (HFd), on the reproductive function of the exposed animals (F1), and their...
AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency phenotypes partially reversible by SIRT3 [0.03%]
AARS2 R199C 突变通过诱导赖酰化驱动的早发性卵巢功能不全表型，部分可通过 SIRT3 逆转
Hai-Hui Zhang,Zhi-Ling Zhang,Wei Xu
Hai-Hui Zhang
Premature ovarian insufficiency (POI) often arises from genetic causes, yet the pathogenic consequences of many variants remain undefined. The AARS2 R199C mutation has been repeatedly reported in patients, but its physiological effects were...
Millions of sperm versus a few oocytes: would this evolutionary battle improve or impair spermatogenesis? A personal opinion [0.03%]
精子几百万 VS 卵子几十颗：这种进化斗争是有利于还是不利于精子发生？个人见解一篇
Vikas Kumar Roy
Vikas Kumar Roy
From fish to mammals, oogenesis has evolved to produce fewer oocytes of the best quality, from approximately millions to a few or one in humans. However, vertebrates from fish to mammals produce an enormous number of sperm. This point of vi...
The roles of NF-κB-Activated Theca Cell Subtypes in Subclinical Premature Ovarian Insufficiency [0.03%]
NF-κB活化的颗粒细胞亚型在亚临床卵巢早衰中的作用
Peigen Chen,Yajie Chang,Jiana Huang et al.
Peigen Chen et al.
Early-onset ovarian insufficiency affects 1-5% of women under the age of 40, but its early pathogenesis remains unclear. This exploratory study employed a small sample design to investigate cellular and molecular alterations in the follicul...
FXR maintains primordial follicle dormancy via regulating FoxO3 expression [0.03%]
法尼醇受体通过调节FoxO3表达维持原始卵泡休眠
Ikuo Tomioka,Asuka Komoshita,Koichi Watanabe et al.
Ikuo Tomioka et al.
Farnesoid X receptor (FXR), a ligand-dependent nuclear receptor predominantly expressed in enterohepatic tissues, is also present in the ovary; however, its role in female reproduction remains unclear. In this study, we investigated the rol...
nphp4 deficiency disrupts testicular homeostasis and impairs male fertility in medaka (Oryzias latipes) [0.03%]
nphp4缺乏干扰斑马鱼睾丸稳态并影响雄性繁殖力
Jingjie Liang,Jiangling Li,Yan Huang et al.
Jingjie Liang et al.
Testicular homeostasis relies on intricate germ cell-somatic cell interactions, yet underlying regulatory mechanisms remain poorly understood. While cilia-related nphp4 mutations cause male infertility, phenotypes show notable interspecies ...
Blockade of T-type Ca2+ channels disrupts mitochondrial function and follicle development by inhibiting the PI3K/AKT pathway [0.03%]
阻断T型Ca2+通道通过抑制PI3K/AKT信号通路干扰线粒体功能和卵泡发育
Xiuling Zhao,Lei Wang,Shiqin Huang et al.
Xiuling Zhao et al.
Calcium (Ca2+) function as critical secondary messengers in cellular signaling, essential for maintaining ovarian function and promoting oocyte maturation. However, the contribution of T-type voltage-gated calcium channels (VGCCs) to ovaria...
TMEM119 Links to Ovarian Endometriosis Progression via MAPK-Mediated Suppression of Ectopic Endometrial Stromal Cell Senescence [0.03%]
TMEM119通过MAPK介导的异位子宫内膜间质细胞衰老抑制作用与卵巢内异症进展相关联
Liansuo Zhang,Zouyu Zhao,Wei Shao et al.
Liansuo Zhang et al.
Transmembrane protein TMEM119 has been implicated in tumor progression (e.g., ovarian cancer), but its role and underlying mechanism in ovarian endometriosis (EM) remain elusive. Thus, this study aimed to investigate the expression pattern ...