Mechanisms of chemotherapy-induced oocyte death through activation of TAp63α [0.03%]
化疗通过激活TAp63α诱导卵母细胞凋亡的作用机制
Niklas Gutfreund,Marcel Tuppi,Birgit Schäfer et al.
Niklas Gutfreund et al.
Premature ovarian insufficiency (POI) is a severe side effect of classical chemotherapy and radiotherapy in treatment of female cancer patients of reproductive age. The molecular mechanisms underlying POI are diverse, ranging from altered h...
Dimethyloxaloylglycine-preconditioned Human Umbilical Cord Mesenchymal Stem Cells Protects Against Early Pregnancy Loss in Mice [0.03%]
二甲基草酰甘氨酸预处理的人脐带间充质干细胞可预防小鼠早期妊娠丢失
Anfeng Ning,Nansong Xiao,Xiaoqin Yu et al.
Anfeng Ning et al.
Early pregnancy loss (EPL), a common pregnancy complication, yet has few effective preventive measures currently. To investigate whether dimethyloxaloylglycine (DMOG)-preconditioned human umbilical cord mesenchymal stem cells (hUC-MSCs) can...
Impact of intraamniotic inflammation on tryptophan metabolism in the placenta-fetal brain axis in rats [0.03%]
宫内炎症影响大鼠胎盘-胎儿大脑轴色氨酸代谢
Cilia Abad,Ivana Musilova,Eva Cifkova et al.
Cilia Abad et al.
The placenta plays a crucial role beyond nutrient transfer, acting as a dynamic endocrine organ that significantly influences maternal physiology and fetal development. It responds rapidly to even slight changes in the in utero environment ...
Histomorphometry and Sperm Quality in Male Rats Exposed to 2.45 GHz Wi-Fi [0.03%]
WIFI（2.45GHz）辐射对雄性大鼠生精小管组织计量学和精子质量的影响
Sivasatyan Vijay,Siti Fatimah Ibrahim,Khairul Osman et al.
Sivasatyan Vijay et al.
Numerous studies have documented the effect of 2.45GHz Wi-Fi exposure on the testes and sperm quality. Nevertheless, detailed histological alterations of other male reproductive organs are underexplored. Therefore, this study aimed to evalu...
Meiotic arrest, resumption, and TZP retraction in bovine COCs undergoing pre-IVM: lessons from a refined GV stage classification [0.03%]
牛卵母细胞在体外成熟前的减数分裂阻滞、恢复及TZP回缩：来自更细致的GV期分类的启示
Helena Fabiana Reis de Almeida Saraiva,Juliano Rodrigues Sangalli,Luana Alves et al.
Helena Fabiana Reis de Almeida Saraiva et al.
The nuclear, cytoplasmic, and molecular maturation of the mammalian oocyte is a finely orchestrated sequence of events that relies on proper cumulus-oocyte communication. Bovine oocytes enter the in vitro maturation systems at the germinal ...
Single nucleotide polymorphism at 5' UTR of H2BC1 and promoter methylation influence TSH2B expression [0.03%]
H2BC1的5'UTR处的单核苷酸多态性和启动子甲基化影响TSH2B表达
Aniket Patankar,Kairavi Joshi,Digumarthi V S Sudhakar et al.
Aniket Patankar et al.
The transition from histones to protamines during spermiogenesis plays a crucial role in shaping the male epigenome, and any changes in this process can impact fertilization potential and the ability of sperm to support early embryogenesis....
Autonomous follicle quality control mechanisms: Innate immune signaling capabilities of granulosa cells [0.03%]
自主的卵泡质量控制机制：颗粒细胞固有的免疫信号能力
Prianka H Hashim,Madeline J Perry,Michele T Pritchard et al.
Prianka H Hashim et al.
We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ov...
Reese S Cameron,Genevieve A Perono,Christian D Natale et al.
Reese S Cameron et al.
With increased use of cannabis world-wide, especially in our young adult population, there is a great impetus to understand the impact of cannabis and its constituents (i.e. THC and CBD) on pregnancy, fetal outcomes, and male and female rep...
Nicotinamide riboside supplementation protects against maternally diabetes-associated decline in oocyte quality [0.03%]
烟酸核糖补充剂可保护卵母细胞质量免受母体糖尿病的影响
Chenlu Wei,Xinxin Zeng,Keer Wang et al.
Chenlu Wei et al.
Diabetes mellitus is strongly correlated with a decline in oocyte quality, however, non-invasive and effective methods to improve this issue have yet to be fully development. Here, we demonstrate that in vivo supplementation with nicotinami...
The effect of Vitamin D (1,25-(OH)2-D3) on human theca and granulosa cell function [0.03%]
维生素D（1,25-（OH）2-D3）对人卵巢间质细胞和颗粒细胞功能的影响
Henrietta Philippa Seaward Brain,Christiana Georgiou,Helen D Mason et al.
Henrietta Philippa Seaward Brain et al.
Numerous studies have investigated the link between Vitamin D (VD) deficiency and reproductive outcomes, with contradictory results. VD regulates steroidogenic enzymes crucial for human granulosa and cumulus cell function. This study invest...