Lipid metabolism abnormalities induced by elevated PCSK9 in PCOS mice lead to ovarian granulosa cell apoptosis via AMPK and GSK-3β [0.03%]
PCSK9上调诱导多囊卵巢综合征小鼠脂质代谢紊乱并协同激活卵泡膜细胞凋亡AMPK和GSK-3β信号通路
Wending Teng,Dan Zhao,Kaiyun Luo et al.
Wending Teng et al.
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder among women of childbearing age, significantly impacting their fertility needs. Granulosa cell apoptosis in the ovaries is one of the primary factors affecting fol...
Jacob R Beal,Purba Mukherjee,Indrani C Bagchi et al.
Jacob R Beal et al.
In humans and rodents, proper formation of a hemochorial placenta is essential for a successful pregnancy, as the placenta serves as the maternal-fetal interface that facilitates the exchange of nutrients, gases, and waste between the mothe...
Human Embryo Exosomal miR-143-3p Impairs Decidualization by Targeting KRAS [0.03%]
人胚外泌体miR-143-3p通过靶向KRAS抑制蜕膜化
Huajing Wanga,Qingyue Wu,Danhui Zuoa et al.
Huajing Wanga et al.
Despite morphological selection, approximately 40% of transferable embryos fail to implant during in vitro fertilization, potentially due to aberrant embryo-maternal cross-talk. Pre-implantation embryos release extracellular vesicles into t...
Electroacupuncture ameliorates Endometriosis-Associated ovarian dysfunction by activating Nrf2 pathway to upregulate GPX4 function and inhibiting ferroptosis [0.03%]
电针通过激活Nrf2通路上调GPX4功能抑制铁死亡从而改善子宫内膜异位症相关卵巢早衰的作用机制研究
Yan Zan,Xiaoquan Huang,Yu Zhuang et al.
Yan Zan et al.
Endometriosis (EMs) is a common cause of ovarian dysfunction and infertility, closely linked to iron overload-induced oxidative stress and ferroptosis. While electroacupuncture (EA) has shown promise in treating reproductive disorders, its ...
N- Carbamoylglutamate enhances bull spermatogenesis via Paraprevotella-Mediated vitamin B6 biosynthesis in rumen microbiota [0.03%]
碳氨甲基谷氨酸通过瘤胃微生物群Paraprevotella介导的维生素B6生物合成增强公牛精子发生
Yueying Wang,Boqi Zhang,Caomeihui Shen et al.
Yueying Wang et al.
N-carbamoylglutamate (NCG), a functional analog of the arginine precursor, shows strong potential in enhancing spermatogenesis in bulls. In this study, dietary NCG supplementation significantly increased sperm density and motility in XiangX...
Selection for Developmental Speed Skews Sex Ratios and Metabolic Profiles in Bovine IVP Embryos [0.03%]
选择发育速度偏移牛体外受精胚胎性别比和代谢谱
Vijay Simha Baddela,Theres Fersterer,Ralf Pöhland et al.
Vijay Simha Baddela et al.
The developmental pace and sex ratio of preimplantation embryos have major implications for pregnancy outcome and herd replacement. We asked whether selecting embryos that develop faster preferentially captures distinct molecular and metabo...
Sertoli cells, but not testicular endothelial cells, contribute to optimized culture of spermatogonia in pigs [0.03%]
猪精子细胞的最佳培养由支持细胞而非睾丸内皮细胞贡献
Xueni You,Zifang Wu,Lin Shi et al.
Xueni You et al.
Spermatogonial stem cells (SSCs) are able to self-renew and differentiate into mature sperm therefore affording life-long male fertility. SSCs are rare in testes, and we previously established a culture system that enabled in vitro propagat...
HMGB1-Induced Perturbations in the Uterine Immune Microenvironment and Implantation Failure in Rats [0.03%]
HMGB1诱导的子宫免疫微环境紊乱及致植物流产作用机制研究动物实验报告
Rithika Rajendran,Sheetal Singhania,Anita Sutar et al.
Rithika Rajendran et al.
Damage-Associated Molecular Patterns (DAMPs) or alarmins are endogenous molecules that activate immune cells and drive an inflammatory response. Derangements in DAMP levels are associated with pregnancy disorders. Our previous study demonst...
Reproductive seasonality drives structural and functional shifts in spermatozoa of the neotropical rattlesnake crotalus durissus (Squamata: Viperidae) [0.03%]
生殖季节性驱动热带响尾蛇(Crotalus durissus)精子结构和功能的变化
Leonardo Carvalho,Carolina Pinhol Vieira,Carla Cristina Martins Silva et al.
Leonardo Carvalho et al.
Reproductive seasonality in snakes can result in dissociation between spermatogenesis and mating, making long-term sperm storage essential. Despite seasonal testicular regression in Crotalus durissus, spermatozoa persist in the distal segme...
Antagonistic Pleiotropy Governing Reproductive Aging: Evolutionary Regulation of Endometrial Receptivity [0.03%]
生殖衰老的拮抗多效性调控：子宫内膜容受性的进化调节机制
Hiroshi Kobayashi,Miki Nishio,Mai Umetani et al.
Hiroshi Kobayashi et al.
This review aims to integrate current knowledge on how mTORC1-centered metabolic and stress-response pathways regulate endometrial decidualization, cellular senescence, and receptivity, with particular emphasis on their impact on implantati...