Knockdown of GRK5 induces mitochondrial hyperpolarization in porcine embryos [0.03%]
GRK5基因敲低诱导猪胚胎线粒体膜电位升高
Ji-Dam Kim,Song-Hee Lee,Qin-Yue Lu et al.
Ji-Dam Kim et al.
In brief: Ferroptosis and mitochondrial hyperpolarization, both linked to oxidative stress, critically compromise embryo development during in vitro culture. This study demonstrates that GRK5 inhibition induces ferroptosi...
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Müllerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome [0.03%]
多囊卵巢综合征的发病机制及影响：妊娠期抗穆勒管激素和睾丸素过多与母体肥胖共同诱发多囊卵巢综合征
David H Abbott,Jon E Levine,Phillip A Dumesic et al.
David H Abbott et al.
In brief: A 'two hit' developmental origin involving testosterone and anti-Müllerian hormone is proposed to initiate PCOS pathogenesis during gestation. Epigenetic mechanisms amplify genetically heritable traits, while a...
Lucila R Gomez-Olivieri,Martina Jabloñski,Martina Griguoli et al.
Lucila R Gomez-Olivieri et al.
In brief: Catsper is an essential calcium channel for sperm capacitation; however, its role in acrosomal exocytosis has not been fully elucidated. This study shows that the lack of Catsper channels in mouse sperm alters t...
Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel [0.03%]
ClC-2氯通道对曲细精管细胞合成睾酮的调节作用
Ssu-Ju Fu,Min-Shan Syu,Chih-Yu Tang et al.
Ssu-Ju Fu et al.
In brief: Leydig cell steroidogenesis is essential for spermatogenesis and male fertility. This research reveals that ClC-2 chloride channels enhance testosterone production via increased expression of steroidogenic genes...
Aubrey M Schaab,Kelsey L Stroud,Dieu Thao Nguyen et al.
Aubrey M Schaab et al.
In brief: This review represents a multispecies summary of the role of pappalysins in female reproductive health. It discusses the potential use of PAPPA and PAPPA2 as biomarkers for oocyte and embryo quality and fetal de...
Kazuaki Suda,Kotaro Takahashi,Ryo Tamura et al.
Kazuaki Suda et al.
In brief: By tissue-selective next-generation sequencing, we showed that adenomyotic epithelium harbored genomic alterations thought to be relevant to the development and progression of adenomyosis, including somatic muta...
Laser capture proteomics reveals new candidates for sperm-interacting proteins in the bovine oviduct epithelium [0.03%]
激光捕获蛋白质组学揭示了牛输卵管上皮细胞与精子相互作用的新的候选蛋白
Coline Mahé,Aleksandra Maria Mowinska,Elke Albrecht et al.
Coline Mahé et al.
In brief: The molecular interactions between spermatozoa and the oviduct epithelium that are involved in capacitation and sperm availability during fertilization still remain largely unknown in many species. This study pr...
Gene expression pattern predictive of human ovarian follicle development and maturation [0.03%]
预测人类卵泡发育和成熟的基因表达模式
Samantha Sperduti,Lara Baschieri,Danilo Cimadomo et al.
Samantha Sperduti et al.
In brief: Granulosa cells from small antral follicles (SFs; diameter 16 mm) for their molecular signatures. SF retain characteristic of early antral follicles and the ratio between follicle-stimulating hormone receptor (F...
Epicatechin inhibits inflammatory injury in preeclampsia extravillous trophoblasts [0.03%]
表儿茶素通过抑制炎症损伤保护子痫前期侵袭性滋养细胞
Mengyongwei Li,Mian Liu,Jiaoqi Mei et al.
Mengyongwei Li et al.
In brief: Preeclampsia is a severe pregnancy-related complication that can result in adverse maternal and fetal outcomes. Current therapeutic options for preeclampsia remain limited. This study demonstrates that epicatech...
Tom Moore
Tom Moore
Abstract: Expansion of the elephant TP53 retrogene family has been proposed to contribute to cancer prevention in this large, long-lived species, consistent with Peto's Paradox. However, the P53 protein acts in several ph...