Epicatechin inhibits inflammatory injury in preeclampsia extravillous trophoblasts [0.03%]
表儿茶素通过抑制炎症损伤保护子痫前期侵袭性滋养细胞
Mengyongwei Li,Mian Liu,Jiaoqi Mei et al.
Mengyongwei Li et al.
In brief: Preeclampsia is a severe pregnancy-related complication that can result in adverse maternal and fetal outcomes. Current therapeutic options for preeclampsia remain limited. This study demonstrates that epicatech...
Tom Moore
Tom Moore
Abstract: Expansion of the elephant TP53 retrogene family has been proposed to contribute to cancer prevention in this large, long-lived species, consistent with Peto's Paradox. However, the P53 protein acts in several ph...
Sustained YAP1 signaling alters the fates of lutein and Müllerian mesenchymal cells in mice [0.03%]
YAP1持续信号改变小鼠卵黄囊和穆勒氏中胚层细胞的命运
Michael Bérubé,Samuel Gusscott,Junhao Mao et al.
Michael Bérubé et al.
Abstract: Recent reports have suggested that the Hippo intracellular signaling pathway is required for homeostasis in a variety of tissues, including the ovary and female reproductive tract. To further define the role of ...
Impacts of maternal excess adiposity on the uterine immune environment: contributions to placental dysfunction and adverse pregnancy outcomes [0.03%]
母体过量脂肪组织对子宫免疫环境的影响：对胎盘功能障碍和不良妊娠结局的贡献
Christian J Bellissimo,Alexander G Beristain,Deborah M Sloboda
Christian J Bellissimo
Abstract: Dynamic compositional and functional changes in the uterine immune environment occur across pregnancy to support placental development and fetal growth. Parental exposures that modify the differentiation, traffi...
Comparison of three modified mouse models of adenomyosis based on invagination theory [0.03%]
基于子宫内膜异位囊肿内陷理论的三种改良小鼠子宫腺肌病模型的比较研究
Song Guo,Di Zhang,Yilin Guo et al.
Song Guo et al.
In brief: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma...
Single-cell multiomic analysis reveals methylome and transcriptome deviations following oocyte maturation in vitro [0.03%]
单细胞多组学分析揭示体外卵母细胞成熟后的甲基化和转录偏差
Camilla Benedetti,Carlo Giaccari,Francesco Cecere et al.
Camilla Benedetti et al.
In vitro maturation of oocytes is a routine step in assisted reproduction but is associated with lower embryo development rates compared to oocyte maturation in vivo. We analyzed the genomic profiles of oocytes from the same cow, either mat...
Anuja Dokras,Manuel Luque-Ramírez,Héctor F Escobar-Morreale
Anuja Dokras
Polycystic ovary syndrome (PCOS) is a widespread condition, with reported prevalences ranging from 5% to 20% worldwide. Being a chronic hyperandrogenic condition, cardiovascular risk factors cluster in young adult women with the syndrome be...
Nuclear Progesterone Receptor Expression, Localization and Function During Bovine Oocyte Growth [0.03%]
牛卵母细胞生长过程中核黄体酮受体的表达、定位和功能研究
Julieta Maria D&#x;Augero,Lais Barbosa Latorraca,Maria Belen Rabagalino et al.
Julieta Maria D&#x;Augero et al.
Previous work from our group demonstrated that blocking nuclear progesterone receptor (nPR) signaling during bovine in vitro oocyte maturation decreases embryo development following subsequent in vitro fertilization and embryo culture, sugg...
Polycystic Ovary Syndrome: Impact of Androgen Excess on Metabolic Health [0.03%]
多囊卵巢综合征：雄激素过多对代谢健康的影响
Leanne Cussen,Tara McDonnell,Clare Miller et al.
Leanne Cussen et al.
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterised by androgen excess, reproductive dysfunction, and metabolic disturbances. Beyond its reproductive implications, hyperandrogenism plays a central role in the path...
Seminal plasma protects frozen-thawed ram spermatozoa from neutrophil attack: a complement mediated dynamic [0.03%]
精液浆保护冻融后的公羊精子免受中性粒细胞攻击：一种补体介导的动态过程
Sophie Warr,Taylor Pini,Simon P de Graaf et al.
Sophie Warr et al.
Following cervical artificial insemination, frozen-thawed (FT) ram spermatozoa display reduced fertility compared to fresh spermatozoa, irrespective of sperm motility and viability, likely attributed to an elevated immune response in the ov...