AMH drives chicken ovarian germline stem cell proliferation through the canonical Smad pathway in the avian ovary [0.03%]
AMH通过经典的Smad途径在鸟类卵巢中驱动鸡卵母细胞干细胞增殖
Qing Sun,Changhao Yu,Hongcai Sun et al.
Qing Sun et al.
The OSCs population in postnatal chickens is a potential reservoir for follicular renewal, however, the signals that regulate OSC maintenance and expansion are not well understood. Here, we identify anti-Müllerian hormone (AMH) as a key mi...
Evidence for a novel role of Pregnancy-Associated Glycoproteins in maintenance of the bovine CL of pregnancy [0.03%]
妊娠相关糖蛋白在维持牛妊娠黄体功能中的新作用证据
Livia Martino-Duarte,João Paulo N Andrade,Pedro L J Monteiro et al.
Livia Martino-Duarte et al.
Embryonic interferon-tau (IFNT) suppresses oxytocin-induced endometrial prostaglandin F2a (PGF) pulses, likely involved in maintaining the bovine CL during early pregnancy. After Day 21 of bovine pregnancy, oxytocin-induced PGF pulses are o...
Ovarian responses to 17ɑ-ethinylestradiol in a marine livebearer, the Southern crested weedfish [0.03%]
17α-乙炔基雌二醇对鱼类卵巢的影响以南拟无须刺胎鱼为模式生物的研究
Rhiannon V Eastment,Shiho Ozeki,Jack L Manera et al.
Rhiannon V Eastment et al.
Pharmaceuticals are fast becoming a major source of environmental pollution. Many pharmaceuticals are endocrine disruptors and can thus interfere with the endocrine system of exposed organisms, leading to a suite of behavioural and physiolo...
Essential role of METTL3 in mitochondrial function and epigenetic regulation during preimplantation development in mice [0.03%]
METTL3在小鼠胚胎着床前发育中的线粒体功能和表观遗传调控中发挥重要作用
Dan Liu,Xinyao Chen,Yuwei Gao et al.
Dan Liu et al.
Methyltransferase-like 3 (METTL3) is a key enzyme involved in N6-methyladenosine (m6A) RNA modification. METTL3 affects mitochondrial function via its well-known contribution to RNA translation and stability. Since METTL3 is essential for p...
Uterine fluid EV miR-223-3p as endometrial receptivity biomarker and regulator in implantation [0.03%]
子宫液中的EV miR-223-3p 是植入窗的标志物和调控因子
Xi Huang,Aihua He,Runxin Gan et al.
Xi Huang et al.
Endometrial receptivity (ER) is a pivotal determinant of successful embryo implantation, yet its regulation by uterine fluid (UF) extracellular vesicles (EVs) remains poorly understood. This study aimed to identify key UF EV miRNAs during t...
Peritoneal Hypoxia as a Gatekeeper Between Physiologic Retrograde Menstruation and Pathologic Persistence in Endometriosis [0.03%]
盆腔缺氧在生理性逆向月经和子宫内膜异位症病理性种植之间的调控作用
Uri Gabbay,Ron Schonman
Uri Gabbay
Several hypotheses have been proposed to explain the establishment of endometriosis, of which retrograde menstruation remains the most widely accepted mechanism of dissemination. However, the mechanisms governing selective lesion establishm...
DUXA is not essential for parthenogenetic blastocyst formation but regulates cell proliferation in porcine embryos [0.03%]
DUXA不是产生孤雌囊胚的必需品，但可调节猪胚胎细胞增殖
Fernanda Luiza Facioli,Werner Giehl Glanzner,Karina Gutierrez et al.
Fernanda Luiza Facioli et al.
Embryonic genome activation (EGA) marks the onset of transcriptional autonomy in the developing embryo, a process that is still not well characterized in pigs. Emerging evidence suggests that chromatin remodeling events during EGA and DNA d...
Pre‑stimulation follicle aspiration enhances ovarian response and oocyte competence via elevated intrafollicular IL‑17 in dairy cows [0.03%]
卵泡抽吸通过提高瘤胃中IL-17的水平增强奶牛的卵巢反应和卵子能力
Yaochang Wei,Dexiang Fan,Yong Wang et al.
Yaochang Wei et al.
The presence of a dominant follicle (DF) during ovarian stimulation (OS) for ovum pick-up (OPU) and in vitro embryo production (IVP) in cattle suppresses subordinate follicle growth, limiting oocyte yield and quality. While DF aspiration pr...
In vitro embryo production alters spatial organisation of mesodermal and endodermal markers in elongating bovine conceptuses [0.03%]
体外胚胎生产改变牛延长期概念胚中内胚层和中胚层标记物的分布
Sara Núñez-Torvisco,Ana Clara Canto Souza,Michael McDonald et al.
Sara Núñez-Torvisco et al.
This study aimed to characterise and compare cell lineage specification in the embryonic disc of elongating bovine conceptuses derived from artificial insemination (AI) or from in vitro-produced embryos, including fresh and cryopreserved bl...
G-Quadruplex Stabilization Impairs Early Embryo Development by Impairing DNA Replication and Inducing R-Loops and DNA Damage Accumulation [0.03%]
G-四链体稳定通过抑制DNA复制、诱导R环和DNA损伤积累而损害早期胚胎发育
Ke Xu,Chao Li,Youhui Lu et al.
Ke Xu et al.
DNA damage or replication impairment can lead to developmental arrest of embryos. To ensure the smooth progression of early embryo development, precise genomic regulation is crucial. Among the regulatory elements of genomic integrity, G-qua...