Redefining Stallion Sperm Bioenergetics: Lessons from a Decade of Change in Mammalian Sperm Metabolism [0.03%]
从哺乳动物精子代谢的十年变革中重定义公畜精子生物能学
Fernando J Peña,Laura Becerro-Rey,Cristina Ortega-Ferrusola et al.
Fernando J Peña et al.
Over the last decade, mammalian sperm metabolism has moved from a binary view centered on glycolysis versus oxidative phosphorylation to an integrated model in which ATP production, redox homeostasis, metabolic plasticity, and cellular hete...
Professor Asgerally T. Fazleabas, University Distinguished Professor, Michigan State University Foundation Professor, Associate Chair for Research, Department of Obstetrics, Gynecology, and Reproductive Biology, Director, Center for Women's Health Research, and Co-Director, Reproductive and Developmental Sciences Training Program, Michigan Stat [0.03%]
Michigan州立大学杰出教授Asgerally T. Fazleabas博士，Michigan州立大学基金会教授，研究副院长，妇产科和生殖医学系，妇女健康研究中心主任，以及生殖和发育科学培训项目联合主任
Bazer Fuller Dr
Bazer Fuller Dr
Interleukin-17A as a key driver for cell migration, proliferation, inflammation, and nerve infiltration in deep endometriosis [0.03%]
细胞迁移、增殖、炎症和神经侵袭在深部浸润性子宫内膜异位症中作用的关键驱动因素IL-17A的作用
Hsiao-Chien Tang,Wan-Ning Li,Tin-Chien Lin et al.
Hsiao-Chien Tang et al.
Deep endometriosis (DE) is the most severe subtype of endometriosis, marked by aggressive cellular behavior and debilitating pain. However, the molecular mechanisms underlying DE pathogenesis remain poorly understood. In this study, we iden...
Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to the cAMP-PKA-CREB pathway inhibition [0.03%]
天冬氨酸甘露糖受体-1通过与FSHR直接结合促进多囊卵巢综合征高雄激素血症的发生，从而抑制cAMP-PKA-CREB通路
Xitong Liu,Juanzi Shi,Ting Wang
Xitong Liu
Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the hepatic...
Estrogen Receptors, via paternal epigenome, regulate genes and pathways involved in embryogenesis [0.03%]
雌激素受体通过父系表观遗传方式调节与胚胎发育相关的基因及通路
Kushaan Khambata,Sanketa Raut,Nafisa H Balasinor
Kushaan Khambata
Activation of Estrogen receptors (ER) signaling in adult male rats leads to sub-fertility, and whole genome bisulfite sequencing revealed large-scale genome-wide changes in sperm DNA methylation. In this study, we further probed the develop...
Identification of potential MicroRNA Markers in Plasma Vesicles for Giant Panda Pregnancy Diagnosis [0.03%]
用于鉴别大熊猫怀孕的潜在标志物MicroRNA的识别研究
Meiling Cheng,Yingmin Zhou,Bo Luo et al.
Meiling Cheng et al.
Extracellular vesicle microRNAs play direct and indirect roles in pregnancy across humans and animal models, making them potential biomarkers for pregnancy detection. Here, a total of 15 blood samples were collected to profile extracellular...
Thigmotactic navigation and functional enrichment of boar sperm in microfluidic channels [0.03%]
微流体通道中公猪精子的触机导航及其功能增益
Mehran Dabiri,Tara Lea Bampton,Roslyn Bathgate et al.
Mehran Dabiri et al.
Efficient sperm selection is crucial for reproductive success in pigs, where artificial insemination (AI) is the main method of assisted reproduction. Traditional methods such as density gradient centrifugation (DGC) can enrich motile sperm...
Functional Identification of miR-21-5p from Fallopian Tubal Extracellular Vesicles as a Promoter of Preimplantation Embryo Viability [0.03%]
来自输卵管细胞外囊泡的miR-21-5p能够促进胚胎植入前存活的功能性鉴定
Yuehan Li,Mingwei Lv,Wenjing Xiong et al.
Yuehan Li et al.
Extracellular vesicles (EVs) released by the maternal reproductive tract provide essential biochemical support for early embryo development, yet the identity of their functional molecular cargo remains largely unclear. In this study, we iso...
The Role of Heterogeneous Nuclear Ribonucleoproteins in Mammalian Spermatogenesis: Mechanisms and Clinical Implications [0.03%]
不均一核核糖核蛋白在哺乳动物精子发生中的作用：机制及临床意义
Kaili Zhou,Kejin Ren,Yijia An et al.
Kaili Zhou et al.
Spermatogenesis in mammals is a complex and highly orchestrated process of cellular development that necessitates precise regulation at the transcriptional, post-transcriptional, and translational levels. RNA binding proteins (RBPs) are int...
Protective Effects of Metformin and Vitamin C on Diabetes-Induced Testicular Dysfunction [0.03%]
二甲双胍和维生素C对糖尿病诱导的睾丸功能障碍的保护作用
Süheyla Esra Özkoçer,Gamze Guney Eskiler,Ece Konac
Süheyla Esra Özkoçer
This study aimed to investigate the potential protective effects of combined metformin (Met) and vitamin C (VitC) therapy on diabetes mellitus (DM)-induced testicular damage, sperm parameters, and the regulation of gene and protein expressi...