Acetaminophen overdose suppresses human extravillous trophoblast invasion by downregulating SP1-mediated MMP2 expression [0.03%]
对乙酰氨基酚过量通过下调SP1介导的MMP2表达抑制人绒毛外滋养细胞侵袭
Yuanyuan Jia,Siwei Luo,Beibei Bi et al.
Yuanyuan Jia et al.
In brief statement: Acetaminophen (APAP) overdose impairs extravillous trophoblast (EVT) cell invasion by inhibiting AKT signaling, leading to downregulation of SP1 and reduced MMP2 expression. These findings highlight a ...
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Epidemiological aspects of polycystic ovary syndrome [0.03%]
多囊卵巢综合征：起源及其影响：多囊卵巢综合征的流行病学方面
Anju E Joham,D Aled Rees,Kanade Shinkai et al.
Anju E Joham et al.
In brief: PCOS is one of the most common endocrine disorders in reproductive-aged women, causing diverse clinical manifestations with significant long-term health impacts. This review provides contemporary epidemiological...
Knockdown of GRK5 induces mitochondrial hyperpolarization in porcine embryos [0.03%]
GRK5基因敲低诱导猪胚胎线粒体膜电位升高
Ji-Dam Kim,Song-Hee Lee,Qin-Yue Lu et al.
Ji-Dam Kim et al.
In brief: Ferroptosis and mitochondrial hyperpolarization, both linked to oxidative stress, critically compromise embryo development during in vitro culture. This study demonstrates that GRK5 inhibition induces ferroptosi...
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Müllerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome [0.03%]
多囊卵巢综合征的发病机制及影响：妊娠期抗穆勒管激素和睾丸素过多与母体肥胖共同诱发多囊卵巢综合征
David H Abbott,Jon E Levine,Phillip A Dumesic et al.
David H Abbott et al.
In brief: A 'two hit' developmental origin involving testosterone and anti-Müllerian hormone is proposed to initiate PCOS pathogenesis during gestation. Epigenetic mechanisms amplify genetically heritable traits, while a...
Lucila R Gomez-Olivieri,Martina Jabloñski,Martina Griguoli et al.
Lucila R Gomez-Olivieri et al.
In brief: Catsper is an essential calcium channel for sperm capacitation; however, its role in acrosomal exocytosis has not been fully elucidated. This study shows that the lack of Catsper channels in mouse sperm alters t...
Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel [0.03%]
ClC-2氯通道对曲细精管细胞合成睾酮的调节作用
Ssu-Ju Fu,Min-Shan Syu,Chih-Yu Tang et al.
Ssu-Ju Fu et al.
In brief: Leydig cell steroidogenesis is essential for spermatogenesis and male fertility. This research reveals that ClC-2 chloride channels enhance testosterone production via increased expression of steroidogenic genes...
Aubrey M Schaab,Kelsey L Stroud,Dieu Thao Nguyen et al.
Aubrey M Schaab et al.
In brief: This review represents a multispecies summary of the role of pappalysins in female reproductive health. It discusses the potential use of PAPPA and PAPPA2 as biomarkers for oocyte and embryo quality and fetal de...
Kazuaki Suda,Kotaro Takahashi,Ryo Tamura et al.
Kazuaki Suda et al.
In brief: By tissue-selective next-generation sequencing, we showed that adenomyotic epithelium harbored genomic alterations thought to be relevant to the development and progression of adenomyosis, including somatic muta...
Laser capture proteomics reveals new candidates for sperm-interacting proteins in the bovine oviduct epithelium [0.03%]
激光捕获蛋白质组学揭示了牛输卵管上皮细胞与精子相互作用的新的候选蛋白
Coline Mahé,Aleksandra Maria Mowinska,Elke Albrecht et al.
Coline Mahé et al.
In brief: The molecular interactions between spermatozoa and the oviduct epithelium that are involved in capacitation and sperm availability during fertilization still remain largely unknown in many species. This study pr...
Gene expression pattern predictive of human ovarian follicle development and maturation [0.03%]
预测人类卵泡发育和成熟的基因表达模式
Samantha Sperduti,Lara Baschieri,Danilo Cimadomo et al.
Samantha Sperduti et al.
In brief: Granulosa cells from small antral follicles (SFs; diameter 16 mm) for their molecular signatures. SF retain characteristic of early antral follicles and the ratio between follicle-stimulating hormone receptor (F...