CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia [0.03%]
CD74缺乏通过SIRT1减少子痫前期滋养细胞侵袭和增殖
Zhenzhen Liu,Jiangnan Pei,Xiaoyue Zhang et al.
Zhenzhen Liu et al.
In brief: Preeclampsia (PE) is a severe complication that leads to major maternal and fetal mortality and morbidity, and one of its causes is extravillous trophoblast (EVT) dysfunction. This study revealed the role of CD7...
Kevin D Sinclair
Kevin D Sinclair
Post-ovulatory aging affects mitochondria, spindle and protein metabolism in mouse oocytes [0.03%]
黄体期老化影响小鼠卵母细胞线粒体、纺锤体和蛋白质代谢
Chuanxin Zhang,Xueqi Dong,Xinyi Yuan et al.
Chuanxin Zhang et al.
In brief: Post-ovulatory aging (POA) results in a decline in oocyte quality and embryonic developmental capacity although the underlying mechanisms remain elusive. This study provides comprehensive mRNA expression profile...
An abnormal LPA/LPAR1-NHE1 axis leads to the autophagy deficiency of trophoblast cells in recurrent spontaneous abortion [0.03%]
异常的LPA/LPAR1-NHE1轴导致复发性自然流产滋养细胞自噬缺陷
Min Chen,Jia-Lu Shi,Zi-Meng Zheng et al.
Min Chen et al.
In brief: Autophagy is important for trophoblast cells at the maternal-fetal interface during early pregnancy. This study suggests that trophoblast cells can promote the autophagy under a regulation of the LPA/LPAR 1-NHE1...
Specc1l deficiency leads to abnormal oocyte meiosis and reduced blastocyst development in mouse [0.03%]
Specc1l缺乏导致小鼠卵母细胞减数分裂异常及囊胚发育率降低
Seulah Lee,Inchul Choi
Seulah Lee
In brief: Proper oocyte maturation is important in early embryo development. This study provides evidence that abnormal meiotic maturation can impact the developmental competency of preimplantation embryos. ...
Sire modulates developmental kinetics and transcriptome of the bovine embryo [0.03%]
Sir调节牛胚胎发育动力学和转录组
Kelsey Nicole Lockhart,Jessica N Drum,Ahmed Z Balboula et al.
Kelsey Nicole Lockhart et al.
In brief: The first week of gestation is a period of major pregnancy loss in cattle, this study reveals that the male plays a key role in regulating embryonic development during this time. ...
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway [0.03%]
大黄素通过HMGB1/TLR4/NF-κB信号通路改善PCOS小鼠糖代谢和卵巢功能
Antonia Otoo,Armin Czika,Jones Lamptey et al.
Antonia Otoo et al.
In brief: Obese PCOS mice display metabolic and endocrine disorders that manifest as abnormal metabolism of glucose and dysfunctions in the reproductive system. This study demonstrates that emodin alleviates most of these...
Maternal restricted- and over- feeding during gestation perturb offspring sperm epigenome in sheep [0.03%]
母体在妊娠期间摄入过量和偏低热量会扰乱羊的精子表观基因组
Linkai Zhu,Nicole Tillquist,Giovanna Scatolin et al.
Linkai Zhu et al.
In brief: Inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. This study shows that maternal restricted - and over- nutrition during gestation do not affect semen character...
Culture of vitrified bovine ovarian tissue on agarose gel inserts maintains follicle integrity [0.03%]
在琼脂糖胶插入物上培养玻璃化的牛卵巢组织可保持卵泡的完整性
Isa Mohammed Alkali,Martina Colombo,Alberto Maria Luciano et al.
Isa Mohammed Alkali et al.
In brief: Ovarian tissue cryopreservation and culture provide an option for fertility preservation without tissue grafting, but need optimization. This study reveals that vitrified bovine ovarian tissue can be cultured on...
Male minipuberty in human and non-human primates: planting the seeds of future fertility [0.03%]
人与非人类灵长类动物的男性青春前期：播种未来生育力的种子
Alexander S Busch,Juan Manuel Paturlanne,Nina Neuhaus et al.
Alexander S Busch et al.
In brief: Minipuberty is a transient activity period of the hypothalamic-pituitary-gonadal axis in the postnatal and infant period including surging serum concentrations of reproductive hormones. Increasing evidence point...