Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children [0.03%]
生殖衰老：当前的认识以及NAD在衰老父亲及其子女的生殖健康中潜在的作用
Morgan B Feuz,D Colton Nelson,Laura B Miller et al.
Morgan B Feuz et al.
In brief: In light of the increasing age of first-time fathers, this article summarizes the current scientific knowledge base on reproductive aging in the male, including sperm quality and health impacts for the offspring...
Inhibition of HSP90AA1 induces abnormalities in bovine oocyte maturation and embryonic development [0.03%]
HSP90AA1的抑制作用可引起牛卵母细胞成熟和胚胎发育异常
Baobao Zhao,Heqiang Li,Han Zhang et al.
Baobao Zhao et al.
In brief: HSP90AA1 is a ubiquitous molecular chaperone that can resist cellular stress, such as oxidative stress and apoptosis, and mediate the efficacy and protein folding of normal cells during heat stress, as well as m...
Congenital Zika virus infection impacts on male mouse offspring's reproductive biology [0.03%]
先天性寨卡病毒感染对雄性小鼠后代生殖生物学的影响
Natália Teixeira Wnuk,André Felipe Almeida Figueiredo,Talita de Oliveira Farias et al.
Natália Teixeira Wnuk et al.
In brief: Congenital ZIKV infection promotes alarming effects on male offspring's reproductive biology. This study showed the presence of the ZIKV antigen in the testis parenchyma, decreased testosterone levels, and sperm...
Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro maturation within a single sample [0.03%]
裸鼹鼠的卵巢允许在同一份样本中研究卵巢储备、体外生殖细胞扩增和卵母细胞体外成熟过程
Gretchen M Rosado,Ana Martinez-Marchal,Mariela Faykoo-Martinez et al.
Gretchen M Rosado et al.
Recently, we described that in the naked mole rat ovary it is possible to study the ovarian reserve and the mitotic expansion of the germ cell postnatally. Herein, we show oocyte in vitro maturation and in vitro germ cell expansion using th...
Oviduct and endometrial epithelium improve in vitro produced bovine embryo developmental kinetics [0.03%]
输卵管和子宫内膜上皮改善体外生产的牛胚胎发育动力学
L Kirsten Senn,Katheryn D Peterson,J Lannett Edwards et al.
L Kirsten Senn et al.
In brief: Standard in vitro produced (IVP) bovine embryo culture media limit embryonic development. Culturing IVP bovine embryos in standard IVP bovine embryo culture media conditioned with oviduct and/or endometrial cell...
Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances [0.03%]
腺肌症导致生育能力下降：一个老鼠模型显示子宫内膜接受能力和黄体酮抗性的不平衡
Marlyne Squatrito,Julie Vervier,Jules Bindels et al.
Marlyne Squatrito et al.
In brief: The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and off...
Peroxisome proliferator-activated receptors and placental function in women with polycystic ovary syndrome [0.03%]
多囊卵巢综合征女性过氧化物酶体增殖物激活受体与胎盘功能的关系
Aimé Silva,Alicia Motta
Aimé Silva
In brief: Adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS) are frequently associated with abnormal placental functions. This review explores the involvement of proliferator-activated receptors (PP...
Isolation of serum-derived placental/amnio-chorionic extracellular vesicles across pregnancy by immunoaffinity using PLAP and HLA-G [0.03%]
利用PLAP和HLA-G通过免疫亲和力在怀孕期间分离血清衍生的胎盘/羊膜绒毛外泌体
Uma Shinde,Aishwarya Rao,Vandana Bansal et al.
Uma Shinde et al.
In brief: Circulating extracellular vesicles of placental/amniochorionic origin carry placental/amniochorionic proteins and nucleic acids with the potential to facilitate non-invasive diagnosis of pregnancy-related disord...
Spindle shape and volume differ in high- and low-quality metaphase II oocytes [0.03%]
高质量和低质量的II期中期卵母细胞的纺锤体形状和体积不同
Monika Fluks,Robert Milewski,Szymon Tamborski et al.
Monika Fluks et al.
In brief: Optical coherence microscopy non-invasively visualizes metaphase II spindles allowing for quantitative analysis of their volume and shape, which may prove useful in the assessment of the oocyte quality. Using a ...
The N-terminal modification of HORMAD2 causes its ectopic persistence on synapsed chromosomes without meiotic blockade [0.03%]
HORMAD2的N端修饰使其在染色体联会时异常持续存在而不阻断减数分裂
Isabella G Cossu,N Adrian Leu,Yongjuan Guan et al.
Isabella G Cossu et al.
In brief: The dissociation of HORMA domain protein 2 (HORMAD2) from the synaptonemal complex is tightly regulated. This study reveals that the N-terminal region of HORMAD2 is critical for its dissociation from synapsed me...