ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells [0.03%]
锌指蛋白146通过转录因子TFDP1和DEPDC1B调节卵巢癌细胞周期进展
Ruixue Zhao,Nana Song,Xin Ning et al.
Ruixue Zhao et al.
In brief: Aberration in cell cycle progression is one of the essential mechanisms underlying tumorigenesis, making regulators of cell cycle reasonable anti-cancer therapeutic targets. Here, we dissected the regulatory mec...
A maternal ketogenic diet alters oviduct fluid nutrients and embryo histone acetylation in mice [0.03%]
母体生酮饮食能改变小鼠输卵管液体中的营养成分和胚胎组蛋白乙酰化状态
Emma G Whatley,Alexandra J Harvey,David K Gardner
Emma G Whatley
In brief: A ketogenic diet (KD) elevates blood β-hydroxybutyrate to concentrations that are known to perturb the development, metabolism, histone acetylation and viability of preimplantation mouse embryos in culture. Thi...
Population decline: where demography, social science, and biology intersect [0.03%]
人口减少：人口学、社会科学和生物学的交叉点
Robert John Aitken
Robert John Aitken
In brief: Over the past half century, the world has witnessed an unprecedented decline in human fertility rates. This analysis reviews the various socioeconomic, cultural, and biological factors involved in driving this c...
Age-dependent high-yield isolation of primordial, primary, and early secondary follicles from the bovine ovarian cortex [0.03%]
年龄依赖性的牛卵巢皮质原发卵泡、初级卵泡和早期二级卵泡高效分离方法
Noemi Monferini,Pritha Dey,Ludovica Donadini et al.
Noemi Monferini et al.
In brief: Preantral follicles constitute the largest follicle reserve in the mammalian ovary. This study assesses a mechanical isolation method to maximize the number of follicles retrieved from a defined cortex volume. ...
Reproductive Ageing: Unlocking the secrets of reproductive longevity: the potential of social insects [0.03%]
生殖老化：解锁生殖长寿的秘密：社会性昆虫的潜力
María Fernanda Vergara-Martínez,Berenice Otero-Díaz,Ingrid Fetter-Pruneda
María Fernanda Vergara-Martínez
In brief: Social insect queens display both extraordinary longevity and fertility. In this point of view, we describe their distinctive traits that make them useful models for reproductive longevity, holding implications ...
The interaction between seminal plasma, sperm, and endometrium in inter- and intra-species breeding in equids [0.03%]
马属动物种间和种内交配中精浆、精子和子宫内膜之间的相互作用
Giorgia Podico,João H Bittar,Shavahn C Loux et al.
Giorgia Podico et al.
In brief: In some instances, extra-species breeding in equids is more successful than intraspecies breeding; however, little is known about the immunomodulatory effect of donkey semen and seminal plasma on the mare's endo...
MEK signalling pathway is required for hypoblast specification and migration in ovine [0.03%]
MAP kinase激活在绵羊卵黄囊发育过程中的作用研究
Nuria Martínez de Los Reyes,Inés Flores-Borobia,Melissa Carvajal-Serna et al.
Nuria Martínez de Los Reyes et al.
In brief: MEK signalling pathway is required for hypoblast differentiation in mouse embryos, but its role in ungulate embryos remains controversial. This paper demonstrates that MEK is required for hypoblast specification...
In silico-designed vitrification protocols: an approach to improve survival of in vitro produced-bovine embryos [0.03%]
基于计算机设计的玻璃化冷冻方案：提高体外生产牛胚胎存活率的方法
Iris Martínez-Rodero,Judith Diaz-Muñoz,Adam Z Higgins et al.
Iris Martínez-Rodero et al.
In brief: In silico predictions validated in this study demonstrate the potential for designing shorter equilibration protocols that improve post-warming re-expansion and hatching rates of D7 and D8 in vitro-produced bovi...
Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation [0.03%]
芦丁通过激活棕色脂肪组织来改善小鼠多囊卵巢综合征
Niuyi Zheng,Chaolong Wang,Yiqiu Li et al.
Niuyi Zheng et al.
In brief: Brown adipose tissue impaired in polycystic ovary syndrome (PCOS) plays a crucial role in the treatment of PCOS. This study shows that myricetin potently improves PCOS by activating brown adipose tissue (BAT). ...
Exosomal or follicular FNDC3A decreases FOLR1 mRNA abundance and progesterone and lactate synthesis in bovine granulosa cells [0.03%]
牛颗粒细胞中exo-FNDC3A或卵泡FNDC3A通过降低FOLR1 mRNA丰度抑制孕酮和乳酸的合成
Mathilde Daudon,Christelle Ramé,Christopher A Price et al.
Mathilde Daudon et al.
In brief: Dairy cattle experience a period of infertility postpartum that is caused in part by the development of IGF1/insulin resistance. This study suggests that an adipokine, FNDC3A, reduces IGF1-dependent glycolysis a...