Hyperglycemia and ZIKV infection cause physiological, immune, and oxidative testicular dysregulation [0.03%]
高血糖和寨卡病毒感染引起生理、免疫和氧化应激调节紊乱
Fernanda Carolina Ribeiro Dias,Marcos de Lucca Moreira Gomes,Katharina Medeiros Costa Gomes et al.
Fernanda Carolina Ribeiro Dias et al.
In brief: Chronic hyperglycemia prolongs ZIKV infection and exacerbates testicular damage in mice. The combined condition severely impairs spermatogenesis through oxidative stress and inflammation. ...
METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner [0.03%]
METTL3介导的m6A修饰通过YTHDF1依赖的方式促进腺肌症中GPX4的铁死亡
Ying Tang,Zili Li,Xin Zhao et al.
Ying Tang et al.
Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis...
Sulfiredoxin stimulates luteinization in vitro by promoting progesterone production in rats [0.03%]
硫化铁蛋白通过促进类固醇生成刺激体外卵泡颗粒细胞黄素化
Sang-Young Chun,Eun-Hye Park,Mari Jang et al.
Sang-Young Chun et al.
In brief: Sulfiredoxin (Srxn1) is essential for corpus luteum formation during ovulation. Inhibition of Srxn1 with J14 suppressed LH-stimulated progesterone production, key gene expressions (Cyp11a1, StAR), and markers of...
Monoclonal antibody potentiating gonadotrophin activity in vitro and in vivo in male and female rats and in ewes [0.03%]
一种抗体在体内外增强促性腺激素活性的作用
Elodie Kara,Jérémy Decourtye,Laurence Dupuy et al.
Elodie Kara et al.
In brief: Treatment of female and male infertility currently depends on repeated injections of gonadotrophins, which can be burdensome for patients and does not always provide successful outcomes. Based on different anima...
Yvonne V Louwers,Jenny A Visser,Andrea Dunaif et al.
Yvonne V Louwers et al.
Polycystic ovary syndrome (PCOS) is a common and heterogeneous disorder currently diagnosed only in reproductive-age women. Familial clustering and twin studies have provided strong evidence for a genetic contribution to PCOS pathogenesis. ...
Sperm capacitation triggers transcriptomic changes linked to the proteasome-mediated ubiquitin-dependent catabolic pathway [0.03%]
精子获能触发与蛋白酶体泛素依赖性分解代谢途径相关的转录组变化
Pedro Caballero-Campo,Cinthya Casas-Ortega,Gabriela Hernández-Silva et al.
Pedro Caballero-Campo et al.
In brief: Molecular changes during human sperm in vitro capacitation were investigated through RNA sequencing and bioinformatic analysis. The ubiquitin-dependent protein catabolic process emerged as a key pathway, and pro...
Major depressive disorder and anti-depressant therapy markedly alters the human follicular niche DNA methylome [0.03%]
抑郁症和抗抑郁药物治疗明显改变了人类卵泡生态位DNA甲基化图谱
Noga Fuchs Weizman,Brandon A Wyse,Cyntia Duval et al.
Noga Fuchs Weizman et al.
In brief: Generalized anxiety disorder, major depressive disorder and their treatment selective serotonin reuptake inhibitors (SSRIs) impact 4-17% of pregnancies worldwide and alter the epigenome of numerous tissues, but ...
Of Mice and Men: translating mouse knockout models of human male infertility [0.03%]
模式生物无精症的小鼠基因敲除模型研究进展
Seleen Barada,Marwa Alameer,Reem Aldhaheri et al.
Seleen Barada et al.
Infertility is a global health issue affecting a significant portion of couples, estimated at ∼10-15% of reproductive-aged couples worldwide, with the World Health Organisation (WHO) suggesting roughly 1 in 6 (∼17.5%) of the adult populat...
The timing of maternal protein degradation during mammalian preimplantation development is species-specific [0.03%]
哺乳动物早期胚胎发育中母源蛋白降解的时机具有物种特异性
Veronika Kinterova,Alexandra Rosenbaum Bartkova,Shanjida Afrin et al.
Veronika Kinterova et al.
In brief: Proper degradation of maternally inherited proteins is a prerequisite for successful embryonic development. This study shows the species-specificity of this process. ...
Na+,K+-ATPase α isoforms in sperm show a highly structured and distinct pattern of distribution [0.03%]
精子中的Na +，K + -ATPase α异构体显示出高度结构化且截然不同的分布模式
Mumtarin J Oishee,Jeffrey P McDermott,Gladis Sánchez et al.
Mumtarin J Oishee et al.
In brief: This manuscript shows that the Na+ and K+ transporter Na+,K+-ATPase α4, specific to sperm, is expressed on the surface of the sperm head and flagellum in a very structured manner. This is also true for Na+,K+-A...