Anita Bichisecchi,Petra Mikec,Christopher Thomas
Anita Bichisecchi
Ovulation is the process by which an egg is released from an ovarian follicle, ready for fertilisation. It is a multi-scale transformation that converts endocrine cues into coordinated tissue and extracellular matrix remodelling, culminatin...
Single-cell Transcriptomic Atlas of Ovarian Endometriosis Patient's Follicular Fluid: Unraveling Novel Insights into Abnormal Follicular Development [0.03%]
单卵泡囊液的单细胞转录组揭示卵巢子宫内膜异位症中异常卵泡发育的新见解
Meng Zhang,Xinye Hu,Haiyan Lin et al.
Meng Zhang et al.
Ovarian endometrioma (OMA), an endometriosis subtype, involves hemorrhagic cysts formed by ectopic endometrial-like tissue, causing pelvic pain, inflammation, and infertility by disrupting ovarian function. Despite its impact, the single-ce...
PGRMC1 suppression enhances progesterone responsiveness in stromal cells of ovarian endometrioma [0.03%]
PGRMC1抑制可增强卵巢子宫内膜异位囊肿基质细胞的孕酮反应性
Yuko Izumi,Yosuke Tarumi,Kota Aoki et al.
Yuko Izumi et al.
Progesterone resistance in endometriosis reduces the efficacy of progestin. The non-classical progesterone receptor, progesterone receptor membrane component 1 (PGRMC1) may regulate progesterone signaling in the normal endometrium, but its ...
Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions [0.03%]
线粒体衍生肽Humanin可通过抗氧化作用保护颗粒细胞
Julia G Conte,Sofía Reynoso,María Sol Gosso et al.
Julia G Conte et al.
Granulosa cell function is essential for proper ovarian physiology. Redox imbalance compromises granulosa cell survival, thereby impacting follicle fate within the ovary. Humanin (HN), a small mitochondrial-derived peptide, exerts cytoprote...
Spatial Transcriptomics in Ovarian Biology Technologies, Computational Challenges, and Biological Insights [0.03%]
卵巢生物学的空间转录组学：技术、计算挑战及生物学启示
Ruixu Huang,Brittany Anne Goods
Ruixu Huang
The ovary is a structurally complex organ whose function depends on precisely coordinated interactions among multiple cell types. Spatially resolved transcriptomics (ST) has emerged as a powerful complement to single-cell RNA sequencing (sc...
Toll-like Receptor 4 Knockout Mice are Protected Against PMOS-like Pathogenesis [0.03%]
toll-like受体4基因敲除小鼠抵抗PMOS病变机制研究
Kiara Wiggins,Zena Del Mundo,Julio Ayala Angulo et al.
Kiara Wiggins et al.
Polyendocrine metabolic ovarian syndrome (PMOS), formerly termed polycystic ovary syndrome (PCOS), is a reproductive disorder with heterogeneous symptoms and severity. Despite extensive research documenting chronic immune dysfunction as a h...
Evidence That Heat Shock Protein A5 (HSPA5) Plays a Role During Bovine In Vitro Embryo Production [0.03%]
热休克蛋白A5（HSPA5）在牛体外生产胚胎过程中起作用的证据
Priscila Helena Dos Santos,Fernanda Fagali Franchi,Sarah Gomes Nunes et al.
Priscila Helena Dos Santos et al.
Oviductal fluid (OF) proteins, such as HSPA5, play essential roles in reproductive physiology, including zona pellucida (ZP)-sperm interactions. Hypothesizing that HSPA5 interacts with oocytes, we evaluated its effects during the last 4 h o...
The use of isoflurane to cause multiple large Ca2+ transients in mouse eggs [0.03%]
异氟烷诱发小鼠卵细胞多次大钙离子振荡的现象及其机制研究
Maryam Al Shaikh,Elnur Aliyev,Zizhen Huang et al.
Maryam Al Shaikh et al.
Mammalian eggs are activated at fertilization by a series of sperm-induced increases in cytosolic Ca2+. The Ca2+ ionophores, A23187 and ionomycin, are used to stimulate a single large Ca2+ transient to induce mammalian egg activation after ...
Fibroblast Growth Factor 9 Promotes Rat Leydig Cell Development via H3K4me3 Histone Modifications [0.03%]
成纤维细胞生长因子9通过组蛋白H3K4me3修饰促进大鼠支持细胞的发育
Hehua Quan,Jiayi He,Feilu Wang et al.
Hehua Quan et al.
Fibroblast Growth Factor 9 (FGF9), as one of the fibroblast growth factor family, is vital for testis formation. Additionally, histone modifications, especially H3K4me3, have been reported to be important in steroidogenesis. However, the re...
The RNA-binding protein Pumilio-2 has roles in the regulation of proliferation and innate immunity of human KGN granulosa tumor cells [0.03%]
RNA结合蛋白Pumilio-2在人KGN颗粒细胞肿瘤增殖和天然免疫中的作用研究
Katja Eubler,Carola Herrmann,Lina Scholz et al.
Katja Eubler et al.
The RNA-binding protein Pumilio-2 (PUM2), encoded by PUM2, is known as a translational repressor with important roles during embryonic development, cell differentiation and synapse function. Information of its roles in the ovary were sparse...