Nonylphenol releases arachidonic acid in rat Sertoli cells via activation of PKA and PLA2 [0.03%]
壬基酚通过活化PKA和PLA2释放大鼠支持细胞花生四烯酸
Florencia X Santiago Valtierra,Paulina Urriola-Muñoz,Rodrigo Godoy-Sepúlveda et al.
Florencia X Santiago Valtierra et al.
In brief: The endocrine disruptor, nonylphenol (NP) increases 20:4n-6 release in Sertoli cells via PKA/cPLA2 activation. Our data show that lipid metabolism could be a target of NP-induced abnormal reproductive outcomes. ...
Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary [0.03%]
生殖老化：卵巢老化的炎症、免疫细胞及细胞衰老现象
José V V Isola,Jessica D Hense,César A P Osório et al.
José V V Isola et al.
In brief: Recent reports suggest a relationship between ovarian inflammation and functional declines, although it remains unresolved if ovarian inflammation is the cause or consequence of ovarian aging. In this review, we...
Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation [0.03%]
子宫内膜异位症中高表达的长链非编码RNA H19促进有氧糖酵解和组蛋白乳酸化
Xiaoyang Wen,Jingyang Zhang,Zihan Xu et al.
Xiaoyang Wen et al.
In brief: Abnormal glucose metabolism may be involved in the pathogenesis of endometriosis. The present study identifies that highly expressed H19 leads to increased aerobic glycolysis and histone lactylation levels in en...
Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes [0.03%]
生殖老化：代谢对哺乳动物卵细胞染色体衰老相关错分的贡献
Bettina P Mihalas,Adele L Marston,Lindsay E Wu et al.
Bettina P Mihalas et al.
In brief: Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segrega...
Characterization of ovarian progenitor cells for their potential to generate steroidogenic theca cells in vitro [0.03%]
卵巢前体细胞的特征化及其在体外生成类固醇分泌卵泡膜细胞的潜能
Xin Wen,Jiexia Wang,Mengjie Qin et al.
Xin Wen et al.
In brief: Progenitor cells with ovulation-related tissue repair activity were identified with defined markers (LGR5, EPCR, LY6A, and PDGFRA), but their potentials to form steroidogenic cells were not known. This study sho...
TGFB1 stimulates the proliferation of quiescent oogonial stem cells in chicken [0.03%]
转化生长因子TGF-B1可促进鸡卵巢中休止卵原干细胞的增殖
Yun Zhang,Wenhui Wu,Yuxiao Ma et al.
Yun Zhang et al.
In brief: Oogonial stem cells in the adult ovary can generate oocytes, but they are usually quiescent. TGFB1 is key in stimulating the proliferation of OSC, thereby ensuring the sustained reproductive potential in poultry...
NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos [0.03%]
NSUN5 对小鼠着床前胚胎细胞增殖和分化至关重要
Dan Liu,Takuto Yamamoto,Haoxue Wang et al.
Dan Liu et al.
In brief: Proper early embryonic development in mammals relies on precise cellular signaling pathways. This study reveals that NSUN5 is crucial for the regulation of the Hippo pathway, ensuring normal proliferation and di...
The current landscape of exercise and female fertility research: a narrative review [0.03%]
当前运动与女性生育力研究的现状：叙述性综述
Rebecca A Maher,Katie Wadden,Daniel Fuller et al.
Rebecca A Maher et al.
In brief: Females with obesity may experience infertility and can improve their fertility through exercise. This review found that most exercise interventions improve fertility outcomes regardless of technique, intensity,...
Reproductive Health in Trans and Gender Diverse Patients: Fertility related knowledge, attitudes, and decision-making among gender diverse youth - A narrative review [0.03%]
关于跨性别和性别多样患者的生殖健康：性别多样化青年中的生育相关知识、态度及决策-综述性文章
Hayley K Baines,Gwendolyn P Quinn,Diane Chen et al.
Hayley K Baines et al.
In brief: Transgender and gender diverse (TGD) youth demonstrate low utilization of fertility preservation before medical and surgical gender-affirming interventions. However, a significant number of TGD youth have goals ...
Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB [0.03%]
RANKL通过NF-κB上调DEC中的ICAM-1促进γδT细胞积累
Rui-Qi Chang,Jing-Cong Dai,Yu-Han Qiu et al.
Rui-Qi Chang et al.
In brief: The mechanism underlying the accumulation of γδT cells in the decidua, which helps maintain maternal-fetal immunotolerance in early pregnancy, is unknown. This study reveals that DSC-derived RANKL upregulates ...