Glucose metabolism disorder related to follicular fluid exosomal miR-122-5p in cumulus cells of endometriosis patients [0.03%]
子宫内膜异位症患者卵泡液中cumulus细胞来源的外泌体miR-122-5p参与糖代谢异常的研究
Jingyi Zhang,Kaiquan Li,Liusijie Gao et al.
Jingyi Zhang et al.
In brief: Elevated expression of miR-122-5p in exosomes in the follicular fluid of patients with endometriosis impairs glucose metabolism in cumulus cells and may further impair oocyte quality. ...
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI [0.03%]
新型PLCZ1复合杂合突变表明总受精失败的ICSI与基因剂量效应有关
Qing Li,Juncen Guo,Gelin Huang et al.
Qing Li et al.
In brief: PLCZ1 mutations are related to total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), characterised by abnormal oocyte oscillations. The novel PLCZ1 compound heterozygous mutations repo...
Chromosomal missegregation and aberrant embryo development in repro57 female mice with Rnf212 homozygous mutation [0.03%]
RNF212基因纯合突变导致小鼠染色体分离异常及胚胎发育畸形
Nanami Sono,Mone Takeshita,Mizuho Chikushi et al.
Nanami Sono et al.
In brief: Repro57 mice, bearing an Rnf212 gene mutation, exhibit infertility in both homozygous mutant males and females, revealing arrested spermatogenesis in males and investigating unclear mechanisms in females. The st...
The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs [0.03%]
牛、羊和猪妊娠期间干扰素刺激基因的变化规律
Gregory A Johnson,Fuller W Bazer,Robert C Burghardt et al.
Gregory A Johnson et al.
In brief: The trophectoderm of the elongating conceptuses of cattle, sheep, and pigs secrete high amounts of interferons that increase or induce the expression of interferon-stimulated genes (ISGs) in the endometrium. Res...
Todd Rosen,Bingbing Wang
Todd Rosen
In brief: The mechanisms that determine the length of pregnancy remain undetermined. Here, we review what has been previously published on the topic and incorporate new data to describe a molecular model in which placenta...
Exosomes of mesenchymal stem cells and PRP restore spermatogenesis in the rat model of non-obstructive azoospermia [0.03%]
间充质干细胞外泌体和富血小板血浆对非梗阻性无精子症大鼠模型生精功能的修复作用
Azar Sheikholeslami,Faeze Davoodi,Hoda Fazaeli et al.
Azar Sheikholeslami et al.
Patients with non-obstructive azoospermia (NOA) are unable to have their children. Therefore, there is an urgent need for additional treatment alternatives for these patients. Recently, novel treatments based on the exosomes derived from me...
Altered histone modification landscapes underpin defects in uterine stromal cell decidualization in aging females [0.03%]
年龄增长通过改变子宫内膜间质细胞蜕膜化过程中染色质可及性与组蛋白修饰景观导致蜕膜化缺陷
Laura Woods,Wendy Dean,Myriam Hemberger
Laura Woods
Decidualization describes the transformation of the uterine stroma in response to an implanting embryo, a process critical for supporting the development of the early embryo, for ensuring normal placentation and ultimately for a healthy rep...
RNA-binding protein SORBS2 increases human trophoblast cell migration via stabilizing HK2 mRNA in preeclampsia [0.03%]
SORBS2蛋白通过稳定HK2 mRNA促进子痫前期人滋养细胞迁移
Limin Song,Xinying Zhao,Jiaxi Chen et al.
Limin Song et al.
Insufficient trophoblast migration and impaired uterine spiral artery remodeling are implicated in the pathogenesis of preeclampsia, contributing to inadequate placentation. However, the molecular mechanism underlying this process remains u...
Expression profiling and function analysis identified new genes regulating cumulus expansion and apoptosis [0.03%]
基因表达谱分析和功能分析鉴定了调控放射冠扩展与凋亡的新基因
Min Zhang,Jia-Shun Wu,Xiao Han et al.
Min Zhang et al.
Studies on the mechanisms behind cumulus expansion and cumulus cell (CC) apoptosis are essential for understanding the mechanisms for oocyte maturation. Genes expressed in CCs might be used as markers for competent oocytes and/or embryos. I...
Stem cell-conditioned medium improves methylation patterns and quality of caprine preantral follicles [0.03%]
干细胞条件培养基可改善波塞口袋期卵泡的甲基化模式和质量
Ana Flávia B Silva,Laritza Ferreira Lima,Renata Patrícia Sousa et al.
Ana Flávia B Silva et al.
This study investigated the methylation patterns of H3K4me3 and H3K9me3, as well as the mRNA expression of genes encoding the epigenetic regulators KDM1AX1, KDM1AX2, and KDM3A in goat preantral follicles developed in vivo (Uncultured contro...