Elucidating metformin action on the ovary and fertility in healthy mice [0.03%]
全面解析二甲双胍在健康小鼠卵巢中的作用及对生育力的影响
Candela Velazquez,Mayra Bordaquievich,Yamila Herrero et al.
Candela Velazquez et al.
In brief: The hypoglycemic drug metformin has shown reproductive effects in women, although its mechanism of action is not fully understood. In this study, we demonstrate the direct effects of metformin on the ovary of he...
Role of L-glutamine in the regulation of rat Sertoli cell proliferation by FSH [0.03%]
L-谷氨酰胺在卵泡刺激素调节大鼠支持细胞增殖中的作用
Cecilia Lucia Centola,Marina Ercilia Dasso,Maria Fernanda Riera et al.
Cecilia Lucia Centola et al.
In brief: FSH leads to glutamine dependence, which is required for mTORC1 activation and in consequence Sertoli cell proliferation. Abstract: ...
Depression-related testosterone deficiency is linked to reduced cholesterol levels in Leydig cells of CUMS mice [0.03%]
抑郁症相关雄激素缺乏与慢性不可预测轻度应激小鼠睾丸间质细胞固醇合成受抑有关
Jiaojiao Huang,Xinyu Li,Dongyu Zhang et al.
Jiaojiao Huang et al.
In brief: Male reproductive problems under psychological stress were widely studied. Using chronically unpredictable mild stress-treated mice, we found that reduced serum testosterone levels were related to the low level ...
REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice [0.03%]
衰老对雄性小鼠生育力、精子质量和后代健康影响的评估及BGP-15干预效力的评估
Macarena B Gonzalez,Carl A Campugan,Haley S Connaughton et al.
Macarena B Gonzalez et al.
In brief: Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. This study in mice identifies a therapeutic compound that, w...
Reproductive Ageing: Declining translational capacity as a potential driver for oocyte meiotic instability [0.03%]
生殖老化：卵子减数分裂不稳定潜在驱动因素——翻译能力下降
Katie J Danielson,Kayla L Judson,Ethan J Greenblatt
Katie J Danielson
In brief: This point of view article focuses on the potential contribution of defects in protein synthesis (translation) to the incidence of oocyte meiotic failure. We discuss the potential cause of diminished oocyte tran...
IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures [0.03%]
现实环境暴露对生殖的影响：暴露于水力压裂化学混合物后对生殖健康产生影响的证据
Kyle R Siegel,Roxanne Bérubé,Matthew Day et al.
Kyle R Siegel et al.
In brief: Unconventional oil and natural gas (UOG) operations, particularly hydraulic fracturing, have revolutionized oil and gas production, using and containing complex mixtures of chemicals that may impact reproductive...
The effects of the activation of TLR2/TLR1 on in vitro angiogenesis in an immortalized ovine luteal endothelial cell line [0.03%]
激活TLR2/TLR1对羊卵巢黄体血管内皮细胞株增殖的影响
Duygu Yaman Gram,Murat Abay,Narin Liman et al.
Duygu Yaman Gram et al.
In brief: Activation of TLR2/TLR1 alters in vitro formation of capillary-like structures and induces inflammatory processes in ovine luteal endothelial (OLENDO) cells. ...
Development of a deep-learning model for detecting positive tubules during sperm recovery for nonobstructive azoospermia [0.03%]
开发用于检测非阻塞性无精子症取精过程中阳性管的深度学习模型
Teppei Takeshima,Jurii Karibe,Shinnosuke Kuroda et al.
Teppei Takeshima et al.
To enhance surgical testicular sperm retrieval outcome for men with nonobstructive azoospermia, a deep-learning model was developed to identify positive seminiferous tubules by labeling 110 images with sperm-containing tubules sampled durin...
Investigations into the role of platelet-activating factor in the peri-conception period of the mare [0.03%]
马属动物围产期血小板活化因子的作用机制研究
Edwina F Lawson,Arnab Ghosh,Christopher Grupen et al.
Edwina F Lawson et al.
In brief: In many mammals, the lipid platelet-activating factor (PAF) has important functions in female reproduction and fertility. This study shows that PAF is present in the reproductive tissues of mares and is involved...
GRK2 is critical for the cleavage of the porcine embryo by regulating HSP90 and the AKT pathway [0.03%]
GRK2通过调节HSP90和AKT信号通路调控猪胚胎卵裂至关重要
Dongjie Zhou,Xiao-Han Li,Song-Hee Lee et al.
Dongjie Zhou et al.
In brief: GRK2 deficiency disrupts the early embryonic development in pigs. The regulation of GRK2 on HSP90 and AKT may also play an important role during embryo development and tumor formation. ...