NSUN2 is critical for mouse oocyte meiosis and early embryonic development [0.03%]
NSUN2对小鼠卵母细胞减数分裂及早期胚胎发育至关重要
Tengteng Xu,Min Gao,Ling Zhang et al.
Tengteng Xu et al.
In brief: The mechanism by which the NSUN2 mutation causes female infertility is still unclear. This study reveals the role and potential mechanism of NSUN2 in mouse oocyte maturation and early embryonic development, and ...
SMC2 ablation impairs bovine embryo development shortly after blastocyst hatching [0.03%]
SMC2基因敲除影响牛胚胎孵化后不久的发育状态
Pérez-Gómez Alba,Flores-Borobia Inés,Hamze Julieta Gabriela et al.
Pérez-Gómez Alba et al.
In brief: Bovine embryos lacking SMC2 (a core component of condensins I and II) are unable to survive maternal recognition of pregnancy. SMC2 KO embryos are able to form blastocysts, exhibiting a reduced cell proliferatio...
Membrane progesterone receptors mediate progesterone-stimulated glycogenolysis in the bovine uterine epithelium [0.03%]
膜孕酮受体介导孕酮刺激的牛子宫上皮糖原分解代谢作用
Malia D Berg,Matthew Dean
Malia D Berg
In livestock, the amount of glucose needed by the endometrium and embryo increases during early pregnancy. Yet, how glucose concentrations in the endometrium are regulated remains unclear. The bovine uterine epithelium can store glucose as ...
Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause [0.03%]
现实环境暴露对生殖的影响：内分泌干扰物、生殖衰老和绝经期
Zane Cutright Inman,Jodi A Flaws
Zane Cutright Inman
In brief: This review article highlights the associations between endocrine-disrupting chemicals, reproductive aging, and menopause. Collectively, the current literature indicates that phthalates, bisphenols, parabens, pe...
Reproductive Health in Trans and Gender Diverse Patients: Effects of transmasculine gender-affirming hormone therapy on future reproductive capacity: clinical data, animal models, and gaps in knowledge [0.03%]
跨性别和性别多样患者的生殖健康：变性男性性别肯定激素治疗对未来生育能力的影响：临床数据、动物模型和知识空白
Ruth Chan-Sui,Robin E Kruger,Evelyn Cho et al.
Ruth Chan-Sui et al.
In brief: Animal studies are needed to inform clinical guidance on the effects of testosterone gender-affirming hormone therapy (T-GAHT) on fertility. This review summarizes current animal models of T-GAHT and identifies ...
Characterization of urethra closure in female neonatal mice at histological and molecular levels [0.03%]
雌性新生小鼠尿道闭合的组织学和分子表征研究
Abigail S Kitakule,Ciro M Amato,Humphrey Hung-Chang Yao
Abigail S Kitakule
In brief: Female hypospadias is a little-known and poorly studied birth defect. This research establishes an anatomical and molecular foundation for future research to investigate the origins of this defect. ...
A scoping review regarding reproductive capacity modulation based on alpha-ketoglutarate supplementation [0.03%]
基于α-酮戊二酸补充剂调节生殖能力的综述研究
Bogdan Doroftei,Ovidiu-Dumitru Ilie,Sergiu Timofeiov et al.
Bogdan Doroftei et al.
In brief: Alpha-ketoglutarate is a common metabolite in the tricarboxylic acid cycle and is central in modulating the reproductive potential in animal models. The present scoping review systematically covers the spectrum ...
Exogenous melatonin ameliorates embryo-maternal cross-talk in early pregnancy in sheep [0.03%]
外源性褪黑素改善绵羊早期妊娠胚胎-母体对话
Irene Viola,Cecilia Sosa,Paolo Accornero et al.
Irene Viola et al.
In brief: Melatonin plays a crucial role in enhancing reproductive performance in small ruminants. This paper reveals the effects of exogenous melatonin on the placental and endometrial rearrangement in early pregnancy in...
IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Impact of developmental exposures to endocrine-disrupting chemicals on pituitary gland reproductive function [0.03%]
环境暴露对生殖的影响：内分泌干扰物的发育暴露对垂体腺生殖功能的影响
Xiyu Ge,Karen Weis,Lori Raetzman
Xiyu Ge
In brief: Endocrine-disrupting chemicals can impact reproduction by affecting the hypothalamic-pituitary-gonadal axis. This review emphasizes the impact of endocrine-disrupting chemicals on pituitary development and funct...
Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells [0.03%]
虫草素通过降低SP1抑制人颗粒细胞卵泡膜细胞甾体急性调节蛋白表达
Lingling Zhang,Shenghui Zhou,Beibei Bi et al.
Lingling Zhang et al.
In brief: Cordycepin (COR), a compound derived from Cordyceps, is recognized as an adenosine analog with numerous beneficial effects on human health. However, its impact on steroidogenic acute regulatory protein (STAR) ex...