Comparative analysis of PI3K-AKT and MEK-ERK1/2 signaling-driven molecular changes in granulosa cells [0.03%]
PI3K-AKT和MEK-ERK1/2信号驱动的颗粒细胞分子变化的比较分析
Vijay Simha Baddela,Marten Michaelis,Xuelian Tao et al.
Vijay Simha Baddela et al.
The PI3K-AKT and MEK-ERK signaling pathways are integral to fundamental cellular processes such as proliferation, viability, and differentiation. In granulosa cells (GCs), these pathways are activated by FSH and IGF1 through respective rece...
Special series on Impact of Real-Life Environmental Exposures on Reproduction [0.03%]
环境暴露与生殖的特殊系列文章
Jodi A Flaws,Vasantha Padmanabhan
Jodi A Flaws
Environmental exposures to endocrine disrupting chemicals (EDCs), air pollution, biosolids, fracking materials, some pharmaceutical agents, and heat stress adversely affect reproductive health and exert long-ranging effects on maternal, pat...
Altered uterine leptin signalling in obese mothers: from impaired decidualisation to pregnancy complications [0.03%]
肥胖母亲的子宫瘦素信号改变：从受损蜕膜化到妊娠并发症
Edyta Walewska,Zahra Hamada,Vicente Pérez-García et al.
Edyta Walewska et al.
Obesity drastically affects maternal health and reproductive outcomes, being often associated with endocrine imbalance, compromised ovarian function, and pregnancy complications. The plastic nature of pregnancy may render the developing fet...
Hypoxia-Inducible Factor inhibition affects luteal function with no effect on fertility in mice [0.03%]
缺氧诱导因子的抑制会影响小鼠黄体功能但对生育没有影响
Rocío Celeste Marinoni,María José España De Marco,Candela Velazquez et al.
Rocío Celeste Marinoni et al.
Hypoxia-inducible factors (HIFs) are transcription factors responsible for sensing low oxygen levels and, in response, inducing the transcription of numerous genes. One of the main processes stimulated by HIFs is the formation of new vessel...
Molly B Moravek,Gene de Haan,Vasantha Padmanabhan
Molly B Moravek
Worldwide, approximately 4.5% of adults identify as transgender or gender diverse (TGD), with up to 8.4% of youth identifying as TGD (Scheim et al 2024), suggesting that the number of TGD patients reaching reproductive age is increasing. Un...
PP1γ1 is unable to substitute for the mammal-specific PP1γ2 isoform to support male fertility and sperm function [0.03%]
PP1γ1不能替代哺乳动物特有的PP1γ2异构体来支持雄性生育力和精子功能
Dr Souvik Dey,Wesam Nofal,Cameron Brothag et al.
Dr Souvik Dey et al.
The serine-threonine phosphatase has four paralogs - PP1α, PP1β, PP1γ1 and PP1γ2 - encoded by three genes, Ppp1ca, Ppp1cb, and Ppp1cc. Protein phosphatase PP1γ2, one of two isoforms of the gene Ppp1cc, is expressed in spermatogenic cel...
Effects of feminizing gender-affirming hormone therapy on testicular function and reproductive capacity [0.03%]
性别肯定激素治疗对睾丸功能和生殖能力的影响
Kenny A Rodriguez-Wallberg,Daniel R Pfau
Kenny A Rodriguez-Wallberg
Feminizing gender affirming hormone therapy (GAHT) may include combined estrogen, progesterone and/or antiandrogens (collectively referred to as E-GAHT) aiming to achieve individualized embodiment goals. This kind of treatment is expected t...
Seminal proteoforms from bulls with contrasting semen freezability: a story deciphered by top-down mass spectrometry [0.03%]
公牛冻精受精能力不同的精子蛋白复合体：由顶向下质谱技术解读的故事
Arabela Guedes de Azevedo Viana,Fabio Pereira Gomes,Abdullah Kaya et al.
Arabela Guedes de Azevedo Viana et al.
Top-down proteomics was employed to construct proteoform atlas of sperm and seminal plasma (SP) from bulls with low (LF) and high (HF) semen freezability. Sperm and seminal proteins were fractionated by tandem size exclusion chromatography ...
Ovine conceptuses express phospholipase inhibitory genes on days 14-15 of pregnancy, interacting with IFNT pathways [0.03%]
小羊胎囊在着床后第14-15天表达抑制磷脂酶的基因，与IFNT通路相互作用
Yuta Matsuno,Kazuya Kusama,Koji Kimura et al.
Yuta Matsuno et al.
In mammals, various molecules are involved in biochemical interaction between conceptus and endometrium for pregnancy recognition and establishment. In ruminants, interferon tau (IFNT) is the pregnancy recognition factor; however, IFNT alon...
Early ovarian differentiation in the tammar wallaby and the effects of exposure to bisphenol A [0.03%]
袋鼠早期卵巢分化及暴露于双酚A的影响
Mario T Peiris,Yu Chen,Geoff Shaw et al.
Mario T Peiris et al.
In brief: Ovarian differentiation in tammar wallabies begins after birth, allowing direct experimental manipulation during the period of differentiation. Using this unique model, we demonstrate that the environmental endo...