Ovarian steroid dependence of endoplasmic reticulum stress involvement in endometrial cell apoptosis during the human endometrial cycle [0.03%]
人子宫内膜周期中内质网应激参与子宫内膜细胞卵巢激素依赖性凋亡作用的依赖关系研究
Jong Yeob Choi,Min Wha Jo,Eun Young Lee et al.
Jong Yeob Choi et al.
Endoplasmic reticulum (ER) stress is a common cellular stress response that enhances apoptosis to trigger cell death. However, recent studies have shown that estrogen suppresses apoptosis by inhibiting ER stress in some cell types, suggesti...
Lactational programming of glucose homeostasis: a window of opportunity [0.03%]
哺乳期的葡萄糖稳态程序建立：一个机会窗口
Lindsay Ellsworth,Emma Harman,Vasantha Padmanabhan et al.
Lindsay Ellsworth et al.
The window of lactation is a critical period during which nutritional and environmental exposures impact lifelong metabolic disease risk. Significant organ and tissue development, organ expansion and maturation of cellular functions occur d...
Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression [0.03%]
褪黑素通过调节SIRT1表达缓解卵母细胞排卵后的功能障碍
Qingling Yang,Shanjun Dai,Xiaoyan Luo et al.
Qingling Yang et al.
The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration as a result of the aging process. Melatonin is considered to be an anti-aging agent. However, the underlying mechanisms of how melatonin improves the...
Bromodomain protein BRD4 is increased in human placentas from women with early-onset preeclampsia [0.03%]
溴结构域蛋白BRD4在早期子痫前期患者滋养细胞和胎盘中的表达增加
Stella Liong,Gillian Barker,Martha Lappas
Stella Liong
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exagg...
Reduced levels of stromal sex hormone-binding globulin and androgen receptor dysfunction in the sperm storage region of the rat epididymis [0.03%]
大鼠附睾精子储备区基质类固醇激素结合蛋白和雄激素受体水平降低
Fabiane de Santi,Flávia L Beltrame,Barry T Hinton et al.
Fabiane de Santi et al.
The cauda epididymidis is the major sperm storage region whose androgenic supply, essential for the sperm viability, is provided by the vasculature and is dependent upon testosterone diffusion through the stromal tissue to reach the epithel...
Long-term exposure to very low doses of bisphenol S affects female reproduction [0.03%]
长期暴露于极低剂量的双酚S影响雌性生殖系统
Jan Nevoral,Yaroslav Kolinko,Jiří Moravec et al.
Jan Nevoral et al.
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used bisphenol A; however, its harmlessness is questionable. The aim...
MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis [0.03%]
间质期大鼠睾丸MEHP诱导的炎症不影响生精细胞凋亡
Jorine J L P Voss,Angela R Stermer,Rashin Ghaffari et al.
Jorine J L P Voss et al.
The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to an...
Initiation of follicular atresia: gene networks during early atresia in pig ovaries [0.03%]
卵泡闭锁的启动：猪卵巢早期闭锁中的基因网络
Jinbi Zhang,Yang Liu,Wang Yao et al.
Jinbi Zhang et al.
In mammals, more than 99% of ovarian follicles undergo a degenerative process known as atresia. The molecular events involved in atresia initiation remain incompletely understood. The objective of this study was to analyze differential gene...
Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice [0.03%]
细胞核糖核酸结合蛋白对小鼠睾丸发育和精子发生至关重要
Bo Zheng,Jun Yu,Yueshuai Guo et al.
Bo Zheng et al.
The cellular nucleic acid-binding protein (CNBP), also known as zinc finger protein 9, is a highly conserved zinc finger protein that is strikingly conserved among vertebrates. Data collected from lower vertebrates showed that CNBP is expre...
Sarah-Jayne Mackin,Avinash Thakur,Colum P Walsh
Sarah-Jayne Mackin
There have been a number of recent insights in the area of genomic imprinting, the phenomenon whereby one of two autosomal alleles is selected for expression based on the parent of origin. This is due in part to a proliferation of new techn...