Diminazene Aceturate, an ACE2 activator, ameliorates testicular injury in diet-induced obese mice [0.03%]
丁氨氮芥乙酰化物（一种ACE2激活剂）改善饮食诱导的肥胖小鼠睾丸损伤
Xiaofeng Yue,Rui Yin,Liling Wu et al.
Xiaofeng Yue et al.
DIZE improved obesity and metabolic disturbances in DIO mice. An increase of sperm account and motility, along with improved morphology and increased male fertility was observed after DIZE treatment. Both serum and intratesticular testoster...
Key glycometabolism during oocyte maturation and early embryonic development [0.03%]
卵母细胞成熟和早期胚胎发育过程中的关键糖代谢路径研究进展
Yichuan Zhang,Tianjie Li,Yibo Wang et al.
Yichuan Zhang et al.
In recent decades, it has become increasingly clear that mammalian gametes and early embryos are highly sensitive to metabolic substrates. With advances in single-cell sequencing, metabolomics, and bioinformatics, we now recognize that meta...
Recombinant FSH induced progesterone via partially regulating let-7 expression in human and mouse granulosa cells [0.03%]
重组FSH通过部分调节let-7的表达诱导人和小鼠颗粒细胞中的孕酮生成
Jing Chen,Lin Chen,Weimin Liu
Jing Chen
Serum progesterone may increase prior to ovulation trigger in in vitro fertilization patients, jeopardizing endometrial receptivity and therefore live birth rate. Recombinant FSH (rFSH) promotes progesterone production from human granulosa ...
Comparison of clinical artificial oocyte activation protocols on mouse egg activation and embryo development [0.03%]
临床人工卵子活化方案在小鼠卵子去皮和胚胎发育中的比较研究
Lucas N González,Valeria Sulzyk,Patricia S Cuasnicú et al.
Lucas N González et al.
Artificial oocyte activation (AOA) with Ca2+ ionophores is an experimental procedure that benefits patients who fail to obtain fertilized eggs. However, the impact of non-physiological Ca2+ increases on cellular events involved in egg-embry...
ERα phosphorylated at Ser309 participates in regulating luminal environment of efferent ducts and epididymis in mice [0.03%]
雌鼠SER309磷酸化ERα参与调节副性腺和附睾的腔内分泌环境
Jinhua Wei,Pang Cheng,Binfang Ma et al.
Jinhua Wei et al.
The estrogen receptor alpha (ERα) plays an important role in male reproduction and fertility. Its activity is modulated by phosphorylation of multiple amino acid residues. The ERα phosphorylated at serine 305 (S305) in human cells (homolo...
Novel insight into CD90 mesenchymal stem cell marker in mouse endometrial stroma during embryo implantation [0.03%]
小鼠着床期子宫内膜间质CD90单阳性间充质干细胞的特征及功能研究
Anna O Gaidamaka,Alena D Alexandrova,Elina S Chermnykh et al.
Anna O Gaidamaka et al.
The endometrium is a dynamic tissue that undergoes significant changes during the reproductive cycle and pregnancy. Its high regenerative capacity is due to the presence of progenitor cells, which maintain tissue homeostasis. Previous studi...
TEAD3 and TEAD4 play overlapping role in bovine preimplantation development [0.03%]
TEAD3和TEAD4在牛植入前胚胎发育中发挥协同作用
Haotian Yu,Yan Shi,Xiaotong Wu et al.
Haotian Yu et al.
During mammalian preimplantation development, the transition from morula to blastocyst is a critical biological event. This process involves polarization and initial specification of lineages, regulated by various transcription factors that...
S100A11 promotes lipid metabolism and activates the apoptosis in polycystic ovary syndrome [0.03%]
S100A11促进多囊卵巢综合征患者的脂质代谢并激活其细胞凋亡作用
Xiao Yang,Qi Jiang,Yanbo Du et al.
Xiao Yang et al.
Apoptosis of ovarian granulosa cells (GCs) affects the development and maturation of oocyte in Polycystic ovary syndrome (PCOS).The objective of our study was to examine the impact of S100A11 on granulosa cells in individuals with polycysti...
Creatine promotes endometriosis progression by inducing M2 polarization of peritoneal macrophages [0.03%]
肌酸通过诱导腹膜巨噬细胞M2极化来促进子宫内膜异位症的发展
Si-Man Chen,Yu-Kai Liu,Xiao-Qian Ma et al.
Si-Man Chen et al.
Endometriosis is a chronic inflammatory disease characterized by the growth of endometrium-like tissues outside the uterine cavity, with an unclear pathogenesis. Analysis of single-cell sequencing data revealed the pivotal role of peritonea...
Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix, and abnormal myometrial architecture in mice [0.03%]
缺失PRICKLE1会导致小鼠不孕不育、细胞外基质异常和子宫平滑肌结构异常
Emily R Roberts,Sornakala Ganeshkumar,Sumedha Gunewardena et al.
Emily R Roberts et al.
Uterine leiomyomas (UL) are the most prevalent benign tumors of the female reproductive tract, originating from the myometrium and affecting over 75% of reproductive-age women. Symptoms of UL include pelvic pain, pressure, dysmenorrhea, men...